[1]王晓月,韩子明,张芳敏,等.糖皮质激素对肾上腺皮质的抑制作用研究进展[J].新乡医学院学报,2021,38(1):097-100.[doi:10.7683/xxyxyxb.2021.01.021]
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糖皮质激素对肾上腺皮质的抑制作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年1
页码:
097-100
栏目:
综述
出版日期:
2021-01-05

文章信息/Info

作者:
王晓月; 韩子明; 张芳敏; 韩玫瑰; 黄　倩
（新乡医学院第一附属医院儿科，河南　卫辉　453100）
关键词:
糖皮质激素; 皮质醇; 促肾上腺皮质激素; 肾上腺皮质功能不全
分类号:
R586
DOI:
10.7683/xxyxyxb.2021.01.021
文献标志码:
A
摘要:
糖皮质激素（GC）具有广泛的生理和药理学作用，临床上主要用于治疗 各种炎症和免疫性疾病。但GC治疗具有一些不良反应，任何给药形式均具有诱发肾上腺皮质功能不全的风险，其诱导肾上腺皮质功能不全的机制与负反馈介导的下丘脑-垂体-肾上腺轴抑制、直接抑制内源性皮质醇的合成和分泌有关。目前研究认为，可通过检测血清皮质醇预测肾上腺皮质功能不全，但国内外关于应用GC治疗过程中出现肾上腺皮质抑制时间的观点尚不统一。本文就GC应用对肾上腺皮质的抑制作用机制及早期测定血清皮质醇以预测肾上腺皮质功能不全出现时间等方面的研究进展加以综述。

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更新日期/Last Update: 2021-01-05