[1]罗羽田,李世朋,徐红伟,等.铁死亡在肝癌中的调控机制及作用研究进展[J].新乡医学院学报,2021,38(1):091-96.[doi:10.7683/xxyxyxb.2021.01.020]
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铁死亡在肝癌中的调控机制及作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年1
页码:
091-96
栏目:
综述
出版日期:
2021-01-05

文章信息/Info

作者:
罗羽田李世朋徐红伟王 迎王建国
(新乡医学院第一附属医院肝胆外科,河南 卫辉 453100)
关键词:
铁死亡肝癌药物作用
分类号:
R735.7
DOI:
10.7683/xxyxyxb.2021.01.020
文献标志码:
A
摘要:
原发性肝癌是我国常见的恶性肿瘤,其复发率、致死率较高,且缺乏有效治疗手段。目前,原发性肝癌的治疗以手术为主,辅助术后放射治疗、化学治疗以及中药治疗。索拉非尼是唯一获批的一线治疗中晚期原发性肝癌药物,可提高患者的生存率,但其出现的不良反应以及后期的耐药性依然导致患者预后不良。肝癌诊治水平依赖于对肝癌发展的研究,从分子水平进行早期干预已经成为临床研究的重点。铁死亡是近年来新发现的一种依赖铁的细胞死亡形式,主要与铁所依赖的脂质过氧化代谢相关,其参与了细胞氧化损伤的发展及氧化还原的失衡,在肿瘤的发生、发展、多重耐药等方面具有重要意义。本文就铁死亡在肝癌中的调控机制、信号通路及作用的研究进展进行综述。

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更新日期/Last Update: 2021-01-05