[1]马 晓,陈国荣,李君艳,等.外周血中性粒细胞与淋巴细胞比值及血清癌胚抗原、糖类抗原199联合检测对结直肠癌的诊断价值[J].新乡医学院学报,2021,38(1):062-65.[doi:10.7683/xxyxyxb.2021.01.013]
 MA Xiao,CHEN Guorong,LI Junyan,et al.Value of combined detection of neutrophil-lymphocyte ratio in peripheral blood,serum carcinoembryonic antigen and carbohydrate antigen 199 in the diagnosis of colorectal cancer[J].Journal of Xinxiang Medical University,2021,38(1):062-65.[doi:10.7683/xxyxyxb.2021.01.013]
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外周血中性粒细胞与淋巴细胞比值及血清癌胚抗原、糖类抗原199联合检测对结直肠癌的诊断价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年1
页码:
062-65
栏目:
临床研究
出版日期:
2021-01-05

文章信息/Info

Title:
Value of combined detection of neutrophil-lymphocyte ratio in peripheral blood,serum carcinoembryonic antigen and carbohydrate antigen 199 in the diagnosis of colorectal cancer
作者:
马 晓陈国荣李君艳杨慧林
(新乡医学院第三附属医院肿瘤内二科,河南 新乡 453003)
Author(s):
MA XiaoCHEN GuorongLI JunyanYANG Huilin
(The Second Department of Oncology,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
结直肠癌中性粒细胞与淋巴细胞比值癌胚抗原糖类抗原199
Keywords:
colorectal cancerneutrophil-lymphocyte ratio carcinoembryonic antigen carbohydrate antigen 199
分类号:
R735.3
DOI:
10.7683/xxyxyxb.2021.01.013
文献标志码:
A
摘要:
目的 探讨外周血中性粒细胞与淋巴细胞比值(NLR)及血清癌胚抗原(CEA)、糖类抗原199(CA199)联合检测在结直肠癌诊断中的应用价值。方法 选择2015年2月至2020年2月新乡医学院第三附属医院收治的结直肠癌患者70例为结直肠癌组,随机选取同期体检健康者55 例为对照组。比较结肠癌组患者及对照组受试者的NLR及血清CEA、CA199表达水平;分析结直肠癌组患者NLR及血清CEA、CA199表达水平与临床病理特征的关系;运用受试者工作特征(ROC)曲线分析NLR及血清CEA、CA199单独及联合诊断结直肠癌发生的曲线下面积(AUC)、灵敏度、特异度,确定最佳截断值。结果 结直肠癌组患者的NLR及血清CEA、CA199水平显著高于对照组 (P<0.05)。结直肠癌组患者的NLR及血清CEA、CA199水平随临床分期的增高而相应增高(P<0.05);低分化患者的NLR及血清CEA、CA199水平高于中、高分化患者(P<0.05)。NLR及血清CEA、CA199单项检测诊断结直肠癌的AUC分别为0.888(95%CI为0.827~0.949)、0.936(95%CI为0.897~0.974)、0.770(95%CI为0.686~0.854),截断值分别为2.48、4.28 μg·L-1、34.40×103 U·L-1,灵敏度分别为84.29%、77.14%、58.57%,特异度分别为92.72%、94.54%、99.55%,约登指数分别为0.77、0.72、0.59;NLR与血清CEA以及NLR与血清CA199联合检测诊断结直肠癌的AUC分别为0.979(95%CI为0.960~0.998)、0.921(95%CI为0.868~0.974),灵敏度分别为94.28%、87.14%,特异度分别为92.72%、92.97%,约登指数分别为0.87、0.80;NLR及血清CEA、CA199水平联合检测诊断结直肠癌的AUC为0.987(95%CI为0.973~1.000),灵敏度为94.28%,特异度为96.36%,约登指数为 0.91。NLR及血清CEA、CA199联合检测时的AUC均高于单项检测(P<0.05)。>结论 NLR及血清CEA、CA199三者联合检测对结直肠癌的诊断有较高临床价值。undefined
Abstract:
Objective To investigate the application value of combined detection of neutrophil-lymphocyte ratio (NLR) in peripheral blood,serum carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) in the diagnosis of colorectal cancer.Methods Seventy patients with colorectal cancer admitted to the Third Affiliated Hospital of Xinxiang Medical University from February 2015 to February 2020 were selected as the colorectal cancer group,and 55 healthy patients in the same period were randomly selected as the control group.The NLR and levels of serum CEA,CA199 in the colorectal cancer group and control group were compared.The relationship between the NLR and serum CEA,CA199 levels and clinicopathological characteristics of patients in the colorectal cancer group was analyzed. The receiver operating characteristic (ROC) curve was used to analyze the area under the curve(AUC),sensitivity and specificity of alone and combined detection of NLR,serum CEA and CA199 for the diagnosis of colorectal cancer,and the optimal cut-off value was determined.Results The NLR and the serum levels of CEA and CA199 in the colorectal cancer group were significantly higher than those in the control group (P<0.05). The NLR and the levels of serum CEA and CA199 in patients with colorectal cancer increased with the increase of clinical stage (P<0.05). The NLR and the levels of serum CEA and CA199 in patients with low histological differentiation were higher than those in patients with medium and high histological differentiation (P<0.05).The AUC for the diagnosis of colorectal cancer by single detection of NLR,serum CEA or serum CA199 were 0.888 (95%CI: 0.827-0.949),0.936(95%CI: 0.897-0.974),0.770 (95%CI: 0.686-0.854);the cut-off values was 2.48,4.28 μg·L-1,34.40×103 U·L-1,respectively;the sensitivity was 84.29%,77.14%,58.57%,respectively;the specificity was 92.72%,94.54%,99.55%,respectively;and Youden index was 0.77,0.72,0.59,respectively.The AUC of combined detection of NLR and serum CEA,NLR and serum CA199 in the diagnosis of colorectal cancer were 0.979(95%CI:0.960-0.998),0.921 (95%CI:0.868-0.974),respectively;the sensitivity was 94.28%,87.14%,respectively;the specificity was 92.72%,92.97%,respectively;and Youden index was 0.87,0.80,respectively. The AUC of the combined detection of NLR,serum CEA and CA199 levels for colorectal cancer was 0.987 (95%CI: 0.973-1.000),the sensitivity was 94.28%,the specificity was 96.36%,and Youden index was 0.91;the AUC of the combined detection of NLR,serum CEA and CA199 levels was higher than that of single detection(P<0.05).Conclusion The combined detection of NLR,serum CEA and CA199 is of great clinical value in the diagnosis of colorectal cancer.

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更新日期/Last Update: 2021-01-05