[1]张景航,薛　云,王冠男,等.幼年性黄色肉芽肿13例病理学分析[J].新乡医学院学报,2021,38(1):048-51.[doi:10.7683/xxyxyxb.2021.01.010]
　ZHANG Jinghang,XUE Yun,WANG Guannan,et al.Pathological analysis of 13 cases of juvenile xanthogranuloma[J].Journal of Xinxiang Medical University,2021,38(1):048-51.[doi:10.7683/xxyxyxb.2021.01.010]
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幼年性黄色肉芽肿13例病理学分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年1
页码:
048-51
栏目:
临床研究
出版日期:
2021-01-05

文章信息/Info

Title:
Pathological analysis of 13 cases of juvenile xanthogranuloma
作者:
张景航1; 2; 薛　云1; 王冠男3; 王现伟4; 5
(1.新乡医学院第一附属医院病理科，河南　卫辉　453100；2.新乡市淋巴造血肿瘤诊断重点实验室，河南　卫辉　453100；3.郑州大学第一附属医院病理科，河南　郑州　450052；4.新乡医学院河南省医用组织再生重点实验室，河南　新乡　453003；5.新乡市分子神经病学重点实验室，河南　新乡　453003）
Author(s):
ZHANG Jinghang1; 2; XUE Yun1; WANG Guannan3; WANG Xianwei4; 5
（1.Department of Pathology,the First Affiliated Hospital of Xinxiang Medical University2.Xinxiang Key Laboratory of Lymphopoietic Tumor Diagnosis3.Department of Pathology,the First Affiliated Hospital of Zhengzhou University4.Henan Key Laboratory of Medical Tissue Regeneration,Xinxiang Medical University5.Xinxiang Key Laboratory of Molecular Neurology）
关键词:
幼年性黄色肉芽肿; 病理学特点; 临床特征
Keywords:
juvenile xanthogranulomapathological characteristicsclinical characteristics
分类号:
R72
DOI:
10.7683/xxyxyxb.2021.01.010
文献标志码:
A
摘要:
目的　总结幼年性黄色肉芽肿的病理学特点。方法　回顾性分析新乡医学院第一附属医院2018年1月至2019年6月确诊的13例幼年性黄色肉芽肿患者的组织病理学特点。结果　13例患者中，男8例，女5例，发病中位年龄为1岁（2个月~11岁），11例为单发皮损，1例为多发皮损，另有1例发生于颅内。其中单发及多发皮损者病变多数位于头面部，未见皮肤以外器官受累；颅内病变为单发、无皮肤及其他器官系统受累。组织病理学表现为表皮轻度变薄，真皮内见边界相对清楚、无包膜的细胞团。高倍镜下可见病变由不同比例的组织细胞、Touton巨细胞及多种炎症细胞组成。免疫组织化学结果显示，皮损处浸润细胞中CD68、CD163、CD4、CD43均呈阳性表达，CD1a呈阴性表达；多数细胞中S-100呈阴性表达，仅少数病例浸润细胞中S-100呈阳性表达。结论　幼年性黄色肉芽肿多为单发皮损，表皮无受累或略变薄，真皮内可见组织细胞浸润，形态相对单一，可见Touton巨细胞及炎症细胞；不典型者及其他器官系统病变可表现为梭形细胞或圆形、类圆形淋巴样细胞浸润，阳性表达CD163、CD68、CD4及CD43。
Abstract:
Objective　To summarize the pathological characteristics of juvenile xanthogranuloma.Methods　　The histopathological characteristics of 13 cases of juvenile xanthogranulomatosis diagnosed in the First Affiliated Hospital of Xinxiang Medical University from January 2018 to June 2019 were analyzed retrospectively.Results　Among the 13 patients,there were 8 male patients and 5 female patients;the median age of onset was 1 year old(2 months to 11 years old).There were 11 cases with single lesions,1 case with multiple lesions and 1 case with central nervous system lesion.Most of single and multiple lesions were located in the head and face,and no other organs except for the skin were involved.Histopathological findings showed that the epidermis was slightly thinned,and the dermis showed relatively clear boundaries and no envelope cell clusters.Under the high power microscope,the lesions were consisted of different proportion of histocytes,Touton giant cells and various inflammatory cells.Immunohistochemical results showed that CD68,CD163,CD4,CD43 were positive expression in infiltrating cells;CD1a was negative expression;S-100 was negative expression in most cells,and S-100 was sporadically positive expression in some cases.Conclusion　Juvenile xanthogranuloma is mostly single skin lesion.The epidermis is not involved or slightly thinned.The infiltration of histiocytic cells can be seen in the dermis,with relatively single morphology,including Touton giant cells and inflammatory cells.The spindle cells or round,quasi-round lymphoid cells infiltration can be observed in atypical patients or other organ system lesions;and the CD163,CD68,CD4 and CD43 are positive expression in the infiltration cells.

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更新日期/Last Update: 2021-01-05