参考文献/References:
［1］ ROURKE J L,DRANSE H J,AINAL C J.CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway［J］.Mol Cell Endocrinol,2015,417:36-51.
［2］ ZABEL B A,ALLEN S J,KULIG P,et al.Chemerin activation by serine proteases of the coag-ulation,fibrinolytic,and inflammatory cascades［J］.J Biol Chem,2005,80(41):34661-34666.
［3］ STOJEK M.The role of chemerin in human disease［J］.Postepy Hig Med Dosw(Online),2017,71:110-117.
［4］ 陈灵丽,田文艳,王颖梅,等.Chemerin在代谢综合征相关肿瘤治疗中的作用及机制［J］.现代肿瘤医学,2020,28(7):1198-1201.
［5］ CHRISTODOULATOS G S,SPYROU N,KADILLARI J,et al.The role of adipokines in breast cancer:current evidence and perspectives［J］.Curr Obes Rep,2019,8(4):413-433.
［6］ CARLINO C,TROTTA E,STABILE H,et al.Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy［J］.J Clin Endocrinol Metab,2012,97(10):3603-3612.
［7］ BONDUE B,WITTAMER V,PARMENTIER M.Chemerin and its receptors in leukocyte trafficking,inflammation and metabolism［J］.Cytokine Growth Factor Rev,2011,22(5-6):331-338.
［8］ GORALSKI K B,MCCARTHY T C,HANNIMAN E A,et al.Chemerin,a novel adipokine that regulates adipogenesis and adipocyte metabolism［J］.J Biol Chem,2007,282(38):28175-28188.
［9］ MURUGANANDAN S,PARLEE S D,ROURKE J L,et al.Chemerin,a novel peroxisome proliferator-activated receptor gamma(PPAR gamma)target gene that promotes mesenchymal stem cell adipogenesis［J］.J Biol Chem,2011,286(27):23982-23995.
［10］ LI X,ZHU Q,WANG W,et al.Elevated chemerin induces insulin resistance in human granulosa-lutein cells from polycystic ovary syndrome patients［J］.FASEB J,2019,33(10):11303-11313.
［11］ GU P,WANG W,YAO Y,et al.Increased circulating chemerin in relation to chronic microvas-cular complications in patients with type 2 diabetes［J］.Int J Endocrinol,2019,2019:8693516.DOI:10.1155/2019/8693516.
［12］ ZHANG J,ZHOU J,TANG X,et al.Reduced expression of chemerin is associated with poor clinical outcome in acute myeloid leukemia［J］.Oncotarget,2017,8(54):92536-92544.
［13］ TREECK O,BUECHLER C,ORTMANN O.Chemerin and cancer［J］.Int J Mol Sci,2019,20(15):3750.
［14］ GORALSKI K B,JACKSON A E,MCKEOWN B T,et al.More than an adipokine:the complex roles of chemerin signaling in cancer［J］.Int J Mol Sci,2019,20(19):4778.
［15］ PACHYNSKI R K,ZABEL B A,KOHRT H E,et al.The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses［J］.J Exp Med,2012,209(8):1427-1435.
［16］ FUNES S C,RIOS M,ESCOBAR-VERA J,et al.Implications of macrophage polarization in autoimmunity［J］.Immunology,2018,154(2):186-195.
［17］ LIN Y,YANG X,YUE W,et al.Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization［J］.Cell Mol Immunol,2014,11(4):355-366.
［18］ LIU CHITTENDEN Y,PATEL D,GASKINS K,et al.Serum RARRES2 is a prognostic marker in patients with adrenocortical carcinoma［J］.Clin Endocrinol Metab,2016,101(9):3345-3352.
［19］ SHIN W J,ZABEL B A,PACHYNSKI R K.Mechanisms and functions of chemerin in cancer:potential roles in therapeutic intervention［J］.Front Immunol,2018,9:2772.
［20］ SONG Y,YIN W,DAN Y,et al.Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via CMKLR1-dependent natural killer cell recruitment［J］.Immunology,2019,157(3):248-256.
［21］ SHIN W J,PACHYNSKI R K.Chemerin modulation of tumor growth:potential clinical applications in cancer［J］.Discov Med,2018,26(141):31-37.
［22］ KRISHNAMURTHY N,KURZROCK R.Targeting the Wnt/β-catenin pathway in cancer:update on effectors and inhibitors［J］.Cancer Treat Rev,2018,62:50-60.
［23］ POLAKIS P.Wnt signaling in cancer［J］.Cold Spring Harb Perspect Biol,2012,4(5):a008052.
［24］ WANG C,WU W K K,LIU X,et al.Increased serum chemerin level promotes cellular invasiveness in gastric cancer:a clinical and experimental study［J］.Peptides,2014,51:131-138.
［25］ LIU-CHITTENDEN Y,JAIN M,GASKINS K,et al.RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma［J］.Oncogene,2017,36(25):3541-3552.
［26］ KAUR J,ADYA R,TAN B K,et al.Identification of chemerin receptor (ChemR23) in human endothelial cells:chemerin-induced endothelial angiogenesis［J］.Biochem Biophys Res Commun,2010,391(4):1762-1768.
［27］ NAKAMURA N,NARUSE K,KOBAYASHI Y,et al.Chemerin promotes angiogenesis in vivo［J］.Physiol Rep,2018,6(24):e13962.
［28］ LIN Y,YANG X,LIU W,et al.Chemerin has a protective role in hepatocellular carcinoma by inhibiting the expression of IL-6 and GM-CSF and MDSC accumulation［J］.Oncogene,2017,36(25):3599-3608.
［29］ ODLE T G.Precision medicine in breast cancer［J］ Radiol Technol,2017,88(4):401M-421M.
［30］ GYRFFY B,LANCZKY A,EKLUND A C,et al.An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients［J］.Breast Cancer Res Treat,2010,123(3):725-731.
［31］ EL-SAGHEER G,GAYYED M,AHMAD A,et al.Expression of chemerin correlates with a poor prognosis in female breast cancer patients［J］ Breast Cancer,2018,10:169-176.
［32］ SARMADI P,TUNALI G,ESENDAGLI-YILMAZ G,et al.CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer［J］.Mol Immunol,2015,68(2PtC):692-698.
［33］ PACHYNSKI R K,WANG P,SALAZAR N,et al.Chemerin suppresses breast cancer growth by recruiting immune effector cells into the tumor microenvironment［J］.Front Immunol,2019,10:983.
［34］ 张杰,骆耐香.Chemerin在乳腺癌小鼠中的表达及其对乳腺癌细胞的影响［C］.第十三届全国免疫学学术大会摘要汇编,2018.
［35］ KIM H,LEE JH,LEE S K,et al.Chemerin treatment inhibits the growth and bone invasion of breast cancer cells［J］.Int J Mol Sci,2020,21(8):2871.
［36］ TORRE L A,TRABERT B,DESANTIS C E,et al.Ovarian cancer statistics,2018［J］.CA Cancer J Clin,2018,68(4):284-296.
［37］ HOFFMANN M,GOGOLA J,PTAK A.Apelin abrogates the sti-mulatory effects of 17β-estradiol and insulin-like growth factor-1 on proliferation of epithelial and granulosa ovarian cancer cell lines via crosstalk between APLNR and ERα/IGF1R［J］.Mol Biol Rep,2019,46(6):6325-6338.
［38］ RAK A,DRWAL E,RAME C,et al.Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and different signaling pathways［J］.Theriogenology,2017,96:126-135.
［39］ RAMA D,ESENDAGLI G,GUC D.Expression of chemokine-like receptor 1 (CMKLR1) on J744A.1 macrophages co-cultured with fibroblast and/or tumor cells:modeling the influence of microenvironment［J］.Cell Immunol,2011,271(1):134-140.
［40］ REVERCHON M,CORNUAU M,RAM C,et al.Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells［J］.Hum Reprod,2012,27(6):1790-1800.
［41］ YAO J,LI Z,FU Y,et al.Involvement of obesity-associated upregulation of chemerin/chemokine-like receptor 1 in oxidative stress and apoptosis in ovaries and granulosa cells［J］.Biochem Biophys Res Commun,2019,510(3):449-455.
［42］ TSIKOURAS P,ZERVOUDIS S,MANAV B,et al.Cervical can-cer:screening,diagnosis and staging［J］.J BUON,2016,21(2):320-325.
［43］ 邹晶晶,朱小飞,余杨.高危型人乳头状瘤病毒载量和Th1/Th2不均衡表达对宫颈病变进程的影响［J］.新乡医学院学报,2019,36(11):1055-1059.
［44］ 陈慎,杜明君,宋雅琴.宫颈组织HPV DNA与血清Chemerin,Leptin水平联合检测对宫颈癌早期诊断的价值分析［J］.现代检验医学杂志,2019,34(3):42-46.
［45］ 刘雪峰,李堰松.血清Chemerin水平在宫颈上皮内瘤变及宫颈癌中的表达及临床意义［J］.中国医师杂志,2016,18(1):81-83.
［46］ 惠玉洁,尉艳芹,李卫民,等.宫颈上皮内瘤变患者血清鳞状细胞癌抗原、巨噬细胞集落刺激因子、趋化素水平变化及意义［J］.实用预防医学,2020,27(1):119-121.
［47］ URICK M E,BELL D W.Clinical actionability of molecular targets in endometrial cancer［J］.Nat Rev Cancer,2019,19(9):510-521.
［48］ 王丽琼,丁晖,杨天丽,等.脂肪因子chemerin在子宫内膜癌患者血清中的表达及意义［J］.中国医学工程,2018,26(9):5-8.
［49］ 余贵媛,代小勇,张键,等.CMKLR1对子宫内膜癌细胞增殖和迁移特性的影响［J］.现代妇产科进展,2018,27(7):512-517.
［50］ VAN ARSDALE A,MILLER D T,KUO D Y,et al.Association of obesity with survival in patients with endometrial cancer［J］.Gynecol Oncol,2019,154(1):156-162.