参考文献/References:
［1］ AMBROS V.The functions of animal microRNAs［J］.Nature,2004,431(7006):350-355.
［2］ KALLA R,VENTHAM N T,KENNEDY N A,et al.MicroRNAs:new players in IBD［J］.Gut,2015,64(3):504-517.
［3］ MAO B，WANG G.MicroRNAs involved with hepatocellular carcinoma (review) ［J］.Oncol Rep,2015,34(6):2811-2820.
［4］ HE M Y，ZHOU W W，LI C，et al.MicroRNAs，DNA damage response，and cancer treatment［J］.Int J Mol Sci,2016,17(12):2087-2101.
［5］ SHEN S J，LIN Y X，YUAN X Y，et al.Biomarker microRNAs for diagnosis，prognosis and treatment of hepatocellular carcinoma:a functional survey and comparison［J］.Sci Rep,2016,6(1):38311-38322.
［6］ PAULEY K M,CHA S.miRNA-146a in rheumatoid arthritis:a new therapeutic strategy［J］.Immunotherapy,2011,3(7):829-831.
［7］ ROITBAK T.MicroRNAs and regeneration in animal models of CNS disorders［J］.Neurochem Res,2020,45(1):188-203.
［8］ SUN K L,LAI E C.Adult-specific functions of anima microRNAs［J］.Nat Rev Genet,2013,14(8):535-548.
［9］ ZEALY R W,WRENN S P,DAVILA S,et al.MicroRNA-binding proteins:specificity and function［J］.Wiley Interdiscip Rev RNA,2017,8(5)：10.1002/wrna.1414.DOI:10.1002/wrna.1414.
［10］ LUND E,GTTINGER S,CALADO A,et al.Nuclear export of microRNA precursors［J］.Science,2004,303(5654):95-98.
［11］ LLAVE C,XIE Z X,KASSCHAU K D,et al.Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA［J］.Science,2002,297(5589):2053-2056.
［12］ HOBERT O.Gene regulation by transcription factors and microRNAs［J］.Science,2008,319(5871):1785-1786.
［13］ LI L,CHEN X P,LI Y J.MicroRNA-146a and human disease［J］.Scand J Immunol,2010,71(4):227-231.
［14］ BOGUNIA-KUBIK K,WYSOCZAN′SKA B,PIATEK D,et al.Significance of polymorphism and expre-ssion of miR-146a and NFkB1 genetic variants in patients with rheumatoid arthritis［J］.Arch Immunol Ther Exp (Warsz),2016,64(Suppl 1):131-136.
［15］ LUO Q,FENG Y H,XIE Y M,et al.Nanoparticle-microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis［J］.Nanomedicine,2019(17):188-197.
［16］ CAGGIU E,PAULUS K,MAMELI G,et al.Differential expre-ssion of miRNA 155 and miRNA 146a in Parkinson′s disease patients［J］.eNeurological Sci,2018,13:1-4.
［17］ WANG Z Y,LIU F,WEI M,et al.Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway［J］.J Neuroinflammation,2018,15(1):179-191.
［18］ DONG Z,JIANG H H,JIAN X F,et al.Change of miRNA expre-ssion profiles in patients with knee osteoarthritis before and after celecoxib treatment［J］.J Clin Lab Anal,2019,33(1):e22648.
［19］ HESSAM S,SAND M,SKYGAN M,et al.Expression of miRNA-155,miRNA-223,miRNA-31,miRNA-21,miRNA-125b,and miRNA-146a in the inflammatory pathway of hidradenitis suppurativa［J］.Inflammation,2017,40(2):464-472.
［20］ BUSHATI N,COHEN S M.MicroRNA functions［J］.Annu Rev Cell Dev Biol,2007,23:175-205.
［21］ ABREU F B,LIU X,TSONGALIS G J.miRNA analysis in pancreatic cancer:the dartmouth experience［J］.Clin Chem Lab Med,2017,55(5):755-762.
［22］ MIZUGUCHI Y,TAKIZAWA T,YOSHIDA H,et al.Dysregulated miRNA in progression of hepatocellular carcinoma:a systematic review［J］.Hepatol Res,2016,46(5):391-406.
［23］ GUO Z,ZHOU H H,ZHANG W.Progress in research on genetic variations in miRNA regulatory pathway［J］.Chin J Med Genet,2015,32(1):109-112.
［24］ DI LEVA G,CHEUNG D G,CROCE C M.miRNA clusters as therapeutic targets for hormone-resistant breast cancer［J］.Expert Rev Endocrinol Metab,2015,10(6):607-617.
［25］ 侯志波.miRNA-146a在胃癌中的表达及功能研究［D］.南京:南京医科大学，2011.
［26］ CHEN Y M,ZHOU B,XU L B,et al.Micro RNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor β-activated kinase1［J］.Mol Med Rep,2017,16(1):755-763.
［27］ YAO Q Y,CAO Z W,TU C T,et al.MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2［J］.Cancer Letters,2013,335 (1):219-224.
［28］ LIU H B,REN G H,ZHU L M,et al.The upregulation of miRNA-146a inhibited biological behaviors of ESCC through inhibition of IRS2［J］.Tumor Biol,2016,37(4):4641-4647.
［29］ 刘华.miRNA-21和miRNA-146a在结直肠肿瘤中的表达及临床意义［D］.青岛：青岛大学,2015.
［30］ KHORRAMI S,ZAVARAN HOSSEINI A,MOWLA S J,et al.MicroRNA-146a induces immune suppression and drug-resistant colorectal cancer cells［J］.Tumour Biol,2017,39(5):1010428317698365.
［31］ IGUCHI T,NAMBARA S,MASUDA T,et al.miR-146a Polymorphism (rs2910164)predicts colorectal cancer patients′ susceptibility to liver metastasis［J］.PLoS One,2016,11(11):e0165912.
［32］ CHEN Y,TANG W F,LIU C,et al.miRNA-146a rs2910164 C>G polymorphism increased the risk of esophagogastric junction adenocarcinoma:a case-control study involving 2,740 participants［J］.Cancer Manag Res,2018,10:1657-1664.
［33］ ZHOU B,DONG L P,JING X Y,et al.Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population［J］.Tumor Biol,2014,35(8):7775-7780.
［34］ CONG N,CHEN H,BU W Z,et al.miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population［J］.Tumor Biol,2014,35 (6):5669-5673.
［35］ PANG L R,LU J E,HUANG J,et al.Upregulation of miR-146a increases cisplatin sensitivity of the non-small cell lung cancer A549 cell line by targeting JNK-2［J］.Oncol Lett,2017,14(6):7745-7752.
［36］ CHEN G,UMELO I A,LV S,et al.miR-146a Inhibits cell growth,cell migration andinduces apoptosis in non-small cell lung cancer cells［J］.PLoS One,2013,8(3):e60317.
［37］ 高永彩,李强,谢灿果,等.非小细胞肺癌患者血清微小RNA-146a水平及其临床意义［J］.临床肿瘤学杂志,2018,23（2）:132-136.
［38］ XIAO S,SUN S Z,LONG W F,et al.A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility［J］.Onco Targets Ther,2018,11:2419-2427.
［39］ TAN W F,LIAO Y,QIU Y,et al.miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP)［J］.Cancer Lett,2018,428:55-68.
［40］ CORNETT A L,LUTZ C S.Regulation of COX-2 expression by miR-146a in lung cancer cells［J］.RNA,2014,20(9):1419-1430.
［41］ WILCZYN′SKI M,ZYTKO E,SZYMAN′SKA B,et al.Expression of miR-146a in patients with ovarian cancer and its clinical signi-ficance［J］.Oncol Lett,2017,14(3):3207-3214.
［42］ MAN Y G,FU S W,LIU A J,et al.Aberrant expression of chromogranin A,miR-146a,and miR-146b-5p in prostate structures with focally disrupted basal cell layers:an early sign of invasion and hormone-refractory cancer［J］.Cancer Genomics Proteomics,2011,8(5):235-244.
［43］ BHAUMIK D,SCOTT G K,SCHOKRPUR S,et al.Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells［J］.Oncegene,2008,27(42):5643-5647.
［44］ KUMARASWAMY E,WENDT K L,Augustine L A,et al.BRCA1 regulation of epidermal growth factor receptor (EGFR)expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function［J］.Oncegene,2015,34（33):4333-4346.
［45］ ALI S,AHMAD A,ABOUKAMEEL A,et al.Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling［J］.Cancer Lett,2014,351(1):134-142.
［46］ RUSSO A,CALTABIANO R,LONGO A,et al.Increased levels of mirna-146a in serum and histologic samples of patients with uveal melanoma［J］.Front Pharmacol,2016,7:424.
［47］ HU H Q,SUN L G,GUO W J.Decreased miRNA-146a in glioblastoma multiforme and regulation of cell proliferation and apoptosis by target Notch1［J］.Int J Biol Markers,2016,31(3):e270-e275.