[1]任亮亮,孔 飞,李 玲,等.依鲁替尼在弥漫大B细胞淋巴瘤临床治疗中的应用研究进展[J].新乡医学院学报,2020,37(11):1089-1092.[doi:10.7683/xxyxyxb.2020.11.019]
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依鲁替尼在弥漫大B细胞淋巴瘤临床治疗中的应用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年11
页码:
1089-1092
栏目:
综述
出版日期:
2020-11-05

文章信息/Info

作者:
任亮亮孔 飞李 玲张明智
(郑州大学第一附属医院肿瘤科,河南 郑州 450052)
关键词:
依鲁替尼弥漫大B细胞淋巴瘤临床研究
分类号:
R733.1
DOI:
10.7683/xxyxyxb.2020.11.019
文献标志码:
A
摘要:
弥漫大B细胞淋巴瘤(DLBCL)是一种最常见的淋巴增生性疾病,侵袭性强且较难诊断。利妥昔单抗、环磷酰胺、阿霉素、长春新碱和强的松联合用药(R-CHOP)化学治疗方案是当前DLBCL患者的一线标准治疗方案,但约30%的DLBCL患者采用R-CHOP方案治愈后会复发,预后极差。布鲁顿酪氨酸激酶(BTK)是B细胞受体信号级联中的关键酶,依鲁替尼作为不可逆的小分子BTK抑制剂,参与B淋巴细胞的生长、增殖和存活过程,可有效抑制恶性B淋巴细胞的增殖和存活。本文就依鲁替尼在DLBCL患者临床治疗中的应用研究进展作一综述。

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更新日期/Last Update: 2020-11-05