[1]张彦平,刘蒙蒙,展新荣.地西他滨联合小剂量高三尖杉酯碱和阿糖胞苷治疗老年急性髓系白血病疗效观察[J].新乡医学院学报,2020,37(11):1068-1070.[doi:10.7683/xxyxyxb.2020.11.014]
 ZHANG Yanping,LIU Mengmeng,ZHAN Xinrong.Effect of decitabine combined with low-dose homoharringtonine and cytarabine in the treatment of elderly patients with acute myeloid leukemia[J].Journal of Xinxiang Medical University,2020,37(11):1068-1070.[doi:10.7683/xxyxyxb.2020.11.014]
点击复制

地西他滨联合小剂量高三尖杉酯碱和阿糖胞苷治疗老年急性髓系白血病疗效观察
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年11
页码:
1068-1070
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

Title:
Effect of decitabine combined with low-dose homoharringtonine and cytarabine in the treatment of elderly patients with acute myeloid leukemia
作者:
张彦平刘蒙蒙展新荣
(新乡市中心医院血液内科,河南 新乡 453000)
Author(s):
ZHANG YanpingLIU MengmengZHAN Xinrong
(Department of Hematology,Xinxiang Central Hospital,Xinxiang 453000,Henan Province,China)
关键词:
急性髓系白血病地西他滨高三尖杉酯碱阿糖胞苷柔红霉素
Keywords:
acute myeloid leukemiadecitabinehomoharringtoninecytarabinedaunorubicin
分类号:
R733.71
DOI:
10.7683/xxyxyxb.2020.11.014
文献标志码:
A
摘要:
目的 探讨地西他滨联合小剂量高三尖杉酯碱和阿糖胞苷治疗老年急性髓系白血病(AML)的临床效果。方法 选择2017年4月至2019年10月新乡市中心医院收治的94例老年AML患者为研究对象,根据治疗方法将患者分为观察组(n=43)和对照组(n=51)。观察组患者给予地西他滨联合小剂量高三尖杉酯碱和阿糖胞苷治疗,对照组患者给予柔红霉素联合阿糖胞苷治疗,2组患者均以7 d为1个疗程,共治疗2个疗程。2组患者治疗1个月后评估临床疗效,并观察治疗期间不良反应发生情况;分别于治疗前及治疗后1个月检测患者白细胞计数(WBC)、红细胞计数(RBC)、血小板计数(PLT)和血红蛋白(HGB)水平。结果 观察组和对照组患者总有效率分别为93.02%(40/43)、76.47%(39/51);观察组患者总有效率显著高于对照组(P<0.05)。治疗前2组患者WBC、RBC、PLT和HGB水平比较差异无统计学意义(P>0.05),2组患者治疗1个月后WBC、RBC、PLT和HGB水平显著高于治疗前(P<0.05);治疗后1个月,观察组患者WBC、RBC、PLT和HGB水平显著高于对照组(P<0.05)。观察组患者贫血性心脏病、重症肺部感染、消化道出血发生率分别为34.88%(15/43)、18.60%(8/43)、13.95%(6/43),对照组患者贫血性心脏病、重症肺部感染、消化道出血发生率分别为68.63%(35/51)、54.90%(28/51)、33.33%(17/51);观察组患者贫血性心脏病、重症肺部感染、消化道出血发生率显著低于对照组(P<0.05)。结论 地西他滨联合小剂量高三尖杉酯碱和阿糖胞苷治疗老年AML疗效较好,且不良反应发生率低。
Abstract:
Objective To investigate the clinical effect of decitabine combined with low-dose homoharringtonine and cytarabine in the treatment of elderly patients with acute myeloid leukemia(AML).Methods A total of 94 elderly patients with AML admitted to Xinxiang Central Hospital from April 2017 to October 2019 were selected as the research subjects,and the patients were divided into observation group(n=43) and control group(n=51) according to the treatment methods.The patients in the observation group were treated with decitabine combined with low-dose homoharringtonine and cytarabine,while the patients in the control group were given daunorubicin combined with cytarabine,and the patients were treated for two course of treatment (7 days were a course of treatment).The clinical effect was evaluated at one month after treatment,and the incidence of adverse reactions during the treatment were observed.The white blood cell count (WBC),red blood cell count (RBC),platelet count (PLT) and hemoglobin (HGB) levels were detected before and one month after treatment.Results The total effective rates in the observation group and the control group were 93.02% (40/43) and 76.47% (39/51),respectively.The total effective rate in the observation group was significantly higher than that in the control group (P<0.05).There was no significant difference in WBC,RBC,PLT and HGB levels between the two groups before treatment (P>0.05).The levels of WBC,RBC,PLT and HGB at one month after treatment were significantly higher than those before treatment in the two groups (P<0.05).The levels of WBC,RBC,PLT and HGB in the observation group were significantly higher than those in the control group at one month after treatment(P<0.05).The incidence rates of anemic heart disease,severe pulmonary infection and gastrointestinal bleeding in the observation group were 34.88% (15/43),18.60% (8/43) and 13.95% (6/43),respectively.The incidence rates of anemic heart disease,severe pulmonary infection and gastrointestinal bleeding in the control group were 68.63%(35/51),54.90%(28/51) and 33.33%(17/51),respectively.The incidence rates of anemic heart disease,severe pulmonary infection and gastrointestinal bleeding in the observation group were significantly lower than those in the control group (P<0.05).Conclusion Decitabine combined with low-dose homoharringtonine and cytarabine is effective in the treatment of elderly AML,and the incidence of adverse reactions is low.

参考文献/References:

[1] 陈华萍,胡明冬,张君国,等.慢性阻塞性肺疾病合并症及其对预后的影响[J].解放军医学杂志,2020,45(8):834-839.
[2] 世界中医药学会联合会.国际中医临床实践指南 慢性阻塞性肺疾病[J].世界中医药,2020,15(7):1084-1092.
[3] 宁凯笛,项永晶,周恬.沙美特罗替卡松联合六君子汤治疗脾肺两虚型稳定期COPD的疗效评价[J].中国地方病防治杂志,2018,33(5):586-586,589.
[4] 陈云霞,李敏,陈晓香,等.联合检测N端脑钠肽前体和D-二聚体在慢性阻塞性肺疾病合并肺栓塞中的诊断价值[J].临床肺科杂志,2017,22(2):329-331.
[5] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2013,36(4):255-264.
[6] 中华医学会呼吸病学分会.肺血栓栓塞症的诊断与治疗指南(草案)[J].中华结核和呼吸杂志,2001,24(5):259-264.
[7] 史琦,王辛秋,孔艳华,等.浅述慢性阻塞性肺疾病与肠道菌群微生态失衡的关系[J].世界中西医结合杂志,2016,11(5):732-736.
[8] FERNANDES P,MACSHARRY J,DARBY T,et al.Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn′s disease:a role for Tollip and peroxisome proliferator-activated receptor gamma[J].Clin Exp Immunol,2016,183(3):358-368.
[9] 黄坤,吴丽丽,杨云生.肠道微生态与人类疾病关系的研究进展[J].传染病信息,2017,30(3):133-137.
[10] 木克热木·亚森,王在义.COPD合并肺血栓栓塞症诊断现状[J].临床肺科杂志,2014,19(6):1091-1093.
[11] OZDEMIREL T S,ULA LI S S,YETI B,et al.Effects of right ventricular dysfunction on exercise capacity and quality of life and associations with serum NT-proBNP levels in COPD:an observational study[J].Anadolu Kardiyol Derg,2014,14(4):370-377.
[12] ZHANG M,ZHANG J,ZHANG Q,et al.D-dimer as a potential biomarker for the progression of COPD[J].Clin Chim Acta,2016,455:55-59.
[13] HU G,WU Y,ZHOU Y,et al.Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD[J].Int J Chron Obstruct Pulmon Dis,2016,11(1):2729-2736.
[14] 刘汉,许飞.慢性阻塞性肺疾病合并肺栓塞的研究进展[J].临床合理用药杂志,2018,11(30):176-177.
[15] 刘晓婷,林光柱,赵学忠,等.303例住院肺栓塞患者危险因素分析[J].中华流行病学杂志,2011,32(12):1275-1277.

相似文献/References:

[1]张婧婧,张楠,王侠,等.急性髓系白血病四色流式细胞术免疫学分型特点分析[J].新乡医学院学报,2011,28(03):323.
[2]崔珊珊,李雅慧,赵晨瑾,等.二甲双胍对人急性髓系白血病KG1a细胞增殖和凋亡的影响及其机制[J].新乡医学院学报,2021,38(10):901.[doi:10.7683/xxyxyxb.2021.10.001]
 CUI Shanshan,LI Yahui,ZHAO Chenjin,et al.Effect and mechanism of metformin on proliferation and apoptosis of human acute myeloid leukemia KG1a cells[J].Journal of Xinxiang Medical University,2021,38(11):901.[doi:10.7683/xxyxyxb.2021.10.001]
[3]赵小强,吴雅莉,仝佳音,等.鱼藤素对急性髓系白血病KG-1a细胞增殖和凋亡的影响及机制[J].新乡医学院学报,2021,38(12):1121.[doi:10.7683/xxyxyxb.2021.12.003]
 ZHAO Xiaoqiang,WU Yali,TONG Jiayin,et al.Effect of deguelin on the proliferation and apoptosis of acute myeloid leukemia KG-1a cells and its mechanism[J].Journal of Xinxiang Medical University,2021,38(11):1121.[doi:10.7683/xxyxyxb.2021.12.003]
[4]申清云,高 大.老年急性髓系白血病的治疗方法研究进展[J].新乡医学院学报,2019,36(1):096.[doi:10.7683/xxyxyxb.2019.01.022]
[5]王继芳,魏秀丽.氟达拉滨联合阿糖胞苷治疗急性髓系白血病疗效观察[J].新乡医学院学报,2018,35(3):204.[doi:10.7683/xxyxyxb.2018.03.011]
 WANG Ji-fang,WEI Xiu-li.Effect of fludarabine combined with cytarabine on acute myeloid leukemia[J].Journal of Xinxiang Medical University,2018,35(11):204.[doi:10.7683/xxyxyxb.2018.03.011]
[6]尹俊杰,梁 波,王继芳,等.阿柔比星为基础的联合化学治疗方案治疗成人初治急性髓系白血病疗效观察[J].新乡医学院学报,2017,34(1):072.[doi:10.7683/xxyxyxb.2017.01.021]
 YIN Jun-jie,LIANG Bo,WANG Ji-fang,et al.Efficacy of aclarubicin-based chemotherapy induction regimens for adult de-novo acute myeloid leukemia[J].Journal of Xinxiang Medical University,2017,34(11):072.[doi:10.7683/xxyxyxb.2017.01.021]
[7]孟君霞,武永强,唐 广,等.CD7抗原表达与急性髓系白血病临床特征、细胞遗传学特点及预后的关系[J].新乡医学院学报,2016,33(6):508.[doi:10.7683/xxyxyxb.2016.06.017]
 MENG Jun-xia,WU Yong-qiang,TANG Guang,et al.Relationship between CD7 antigen expression and clinical features,cytogenetic features,prognosis of acute myeloid leukemia[J].Journal of Xinxiang Medical University,2016,33(11):508.[doi:10.7683/xxyxyxb.2016.06.017]
[8]张晓冬,林晓媛.急性髓系白血病患者外周血调节性T细胞、辅助性T细胞17及其相关细胞因子的表达及意义[J].新乡医学院学报,2023,40(4):339.[doi:10.7683/xxyxyxb.2023.04.008]
 ZHANG Xiaodong,LIN Xiaoyuan.Expression and significance of regulatory T cells,helper T cell 17 cells and their related cytokines in peripheral blood of patients with acute myeloid leukemia[J].Journal of Xinxiang Medical University,2023,40(11):339.[doi:10.7683/xxyxyxb.2023.04.008]
[9]张彦平,刘蒙蒙,展新荣.地西他滨联合三氧化二砷治疗老年急性髓系白血病的疗效及安全性[J].新乡医学院学报,2019,36(12):1163.[doi:10.7683/xxyxyxb.2019.12.015]
 ZHANG Yan-ping,LIU Meng-meng,ZHAN Xin-rong.Evaluation of the efficacy and safety of decitabine combined with arsenic trioxide in the treatment of senile acute myeloid leukemia[J].Journal of Xinxiang Medical University,2019,36(11):1163.[doi:10.7683/xxyxyxb.2019.12.015]

更新日期/Last Update: 2020-11-05