[1]魏雨菲,于海川,刘雪玲,等.姜黄主要化学成分及药理作用研究进展[J].新乡医学院学报,2020,37(10):990-995.[doi:10.7683/xxyxyxb.2020.10.020]
点击复制

姜黄主要化学成分及药理作用研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年10
页码:
990-995
栏目:
综述
出版日期:
2020-10-05

文章信息/Info

作者:
魏雨菲1于海川1刘雪玲1高 琪1殷旭颖1尹 航1吴 娇2
(1.新乡医学院医学检验学院,河南省分子诊断与医学检验技术协同创新中心,河南  新乡 453003;2.新乡医学院药学院,河南 新乡 453003)
关键词:
姜黄姜黄素抗肿瘤解毒抗炎抗氧化糖尿病
分类号:
R284.1
DOI:
10.7683/xxyxyxb.2020.10.020
文献标志码:
A
摘要:
中药姜黄是一种多年生草本植物,具有破血行气、通经止痛等功效,其化学成分具有抗氧化、抗炎、抗肿瘤、抗糖尿病等药理作用。本文主要对近年来姜黄主要化学成分姜黄素的药理作用及机制研究进展进行综述,为其临床用药和开发利用提供参考依据。

参考文献/References:

[1] MOMTAZI A A,SAHEBKAR A.Difluorinated curcumin:a promi-sing curcumin analogue with improved anti-tumor activity and pharmacokinetic profile[J].Curr Pharm Des,2016,22(28):4386-4397.
[2] TEYMOURI M,PIRRO M,JOHNSTON T P,et al.Curcumin as a multifa-ceted compound against human papilloma virus infection and cervical cancers:a review of chemistry,cellular,molecular,and preclinical features[J].Biofactors,2017,43(3):331-346.
[3] MOMTAZI A A,SHAHABIPOUR F,KHATIBI S,et al.Curcumin as a microRNA regulator in cancer:a review[J].Rev Physiol Biochem Pharmacol,2016,171:1-38.
[4] MIRZAEI H,MASOUDIFAR A,SAHEBKAR A,et al.MicroRNA:a novel target of curcumin in cancer therapy[J].J Cell Physiol,2018,233(4):3004-3015.
[5] SHAFABAKHSH R,POURHANIFEH M H,MIRZAEI H R,et al.Targeting regulatory T cells by curcumin:a potential for cancer immunotherapy[J].Pharmacol Res,2019,147:104353.
[6] BOSE S,PANDA A K,MUKHERJEE S,et al.Curcumin and tumor immune-editing:resurrecting the immune system[J].Cell Div,2015,10(1):131-144.
[7] LIAO F,LIU L,LUO E,et al.Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma[J].Arch Oral Biol,2018,92:32-37.
[8] CAVALERI F.Presenting a new standard drug model for turmeric and its prized extract,curcumin[J].Int J Inflam,2018,2018:310-328.
[9] NAIR A,AMALRAJ A,JACOB J,et al.Non-curcuminoids from turmeric and their potential in cancer therapy and anticancer drug delivery formulations[J].Biomolecules,2019,9(1):1011-1047.
[10] YUE G G,CHAN B C,HON P M,et al.Evaluation of in vitro antiproliferative and immunomodulatory activities of compounds isolated from curcuma longa[J].Food Chem Toxicol,2010,48(8/9):2011-2020.
[11] KIM D,SUH Y,LEE H,et al.Immune activation and antitumor response of ar-turmerone on P388D1 lymphoblast cell implanted tumors [J].Int J Mol Med,2013,31(2):386-392.
[12] MUKUNTHAN K S,SATYAN R S,PATEL T N.Pharmacological evaluation of phytochemicals from South Indian Black Turmeric (Curcuma caesia Roxb) to target cancer apoptosis[J].J Ethnopharmacol,2017,209:82-90.
[13] ZHAN Y H,LIU J,QU X J,et al.β-elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/mTOR signalling pathways[J].Asian Pac J Cancer Prev,2012,13(6):2739-2744.
[14] ZHONG Z F,HOI P M,WU G S,et al.Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo[J].J Ethnopharmacol,2012,141(2):721-727.
[15] LI Y W,ZHU G Y,SHEN X L,et al.Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells[J].Cancer Chemother Pharmacol,2011,68(5):1315-1323.
[16] LU J J,DANG Y Y,HUANG M,et al.Anti-cancer properties of terpenoids isolated from Rhizoma curcumae:a review[J].J Ethnopharmacol,2012,143(2):406-411.
[17] KUMAR A,BORA U.Molecular docking studies of curcumin natural derivatives with DNA topoisomerase I and II-DNA complexes[J].Interdiscip Sci,2014,6(4):285-291.
[18] XIE X H,ZHAO H,HU Y Y,et al.Germacrone reverses Adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cells[J].Exp Ther Med,2014,8(5):1611-1615.
[19] HOSSEINI A,HOSSEINZADEH H.Antidotal or protective effects of Curcuma longa(turmeric) and its active ingredient,curcumin,against natural and chemical toxicities:a review[J].Biomed Pharmacother,2018,99:411-421.
[20] EL-MAHALAWAY ABEER M.Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats:a histological and immunohisochemical study[J].Int J Clin Exp Pathol,2015,8(6):6019-6030.
[21] KHORSANDI L,ORAZIZADEH M.Protective effect of Curcuma longa extract on acetaminophen induced nephrotoxicity in mice[J].Daru,2008,16(3):155-159.
[22] GHOSH J,DAS J,MANNA P,et al.Acetaminophen induced renal injury via oxidative stress and TNF-α production:therapeutic potential of arjunolic acid[J].Toxicology,2010,268(1/2):8-18.
[23] ISMAIL A F M,SALEM A A M.Renoprotective effect of curcumin on acetaminophen-induced nephrotoxicity in rats[J].J Chem Pharm Res,2016,8(2):773-779.
[24] EL-RAHMAN S A,AL-JAMEEL S S.Protection of curcumin and curcumin nanoparticles against cisplatin induced nephrotoxicity in male rats[J].Sch Acad J Biosci,2014,2(3):214-223.
[25] UGUR S,ULU R,DOGUKAN A,et al.The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity[J].Ren Fail,2015,37(2):332-336.
[26] SALAHSHOOR M,MOHAMADIAN S,KAKABARAEI S,et al.Curcumin improves liver damage in male mice exposed to nicotine[J].J Tradit Complement Med,2015,6(2):176-183.
[27] LIANG Z F,WU R,XIE W,et al.Effects of curcumin on tobacco smoke-induced hepatic MAPK pathway activation and epithelial-mesenchymal transition in vivo[J].Phytother Res,2017,31(8):1230-1239.
[28] YOUSEF M I,EL-DEMERDASH F M,RADWAN F M E.Sodium arsenite induced biochemical perturbations in rats:ameliorating effect of curcumin[J].Food Chem Toxicol,2008,46(11):3506-3511.
[29] EL-SAYED E M,EL-AZEEM A S,AFIFY A A,et al.Cardioprotective effects of Curcuma longa L.extracts against doxorubicin-induced cardiotoxicity in rats[J].J Med Plant Res,2011,5(17):4049-4058.
[30] CHAKRABORTY M,BHATTACHARJEE A,KAMATH J V.Cardioprotective effect of curcumin and piperine combination against cyclophosphamide-induced cardiotoxicity[J].Indian J Pharmacol,2017,49(1):65-70.
[31] KUKONGVIRIYAPAN U,PANNANGPETCH P,KUKONGVIRIYAPAN V,et al.Curcumin protects against cadmium-induced vascular dysfunction,hypertension and tissue cadmium accumulation in mice[J].Nutrients,2014,6(3):1194-1208.
[32] HASSANI S,SEPAND M R,JAFARI A,et al.Protective effects of curcumin and vitamin E against chlorpyrifos-induced lung oxidative damage[J].Hum Exp Toxicol,2015,34(6):668-676.
[33] KUMAR A,DOGRA S,PRAKASH A.Protective effect of curcumin(Curcuma longa),against aluminium toxicity:possible behavioral and biochemical alterations in rats[J].Behav Brain Res,2009,205(2):384-390.
[34] SETHI P,JYOTI A,HUSSAIN E,et al.Curcumin attenuates aluminium-induced functional neurotoxicity in rats[J].Pharmacol Biochem Behav,2009,93(1):31-39.
[35] PRASAD S N,MURALIDHARA M.Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in drosophila melanogaster:relevance to neuropathy[J].J Insect Physiol,2014,60(1):7-16.
[36] CUI Q L,LI X,ZHU H C.Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway[J].Mol Med Rep,2016,13(2):1381-1388.
[37] EKE-OKORO U J,RAFFA R B,PERGOLIZZI J R J V,et al.Curcumin in turmeric:basic and clinical evidence for a potential role in analgesia[J].J Clin Pharm Ther,2018,43(4):460-466.
[38] MADHU K,CHANDA K,SAJI M J.Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis:a randomized placebo-controlled trial[J].Inflammopharmacology,2013,21(2):129-136.
[39] SAHBAIE P,SUN Y,LIANG D Y,et al.Curcumin treatment attenuates pain and enhances functional recovery after incision[J].Anesth Analg,2014,118(6):1336-1344.
[40] TABRIZI R,VAKILI S,AKBARI M,et al.The effects of curcumin-containing supplements on biomarkers of in flammation and oxidative stress:a systematic review and meta-analysis of rando-mized controlled trials[J].Phytother Res,2019,33(2):253-262.
[41] WILLENBACHER E,KHAN S Z,MUJICA S C A,et al.Curcumin:new insights into an ancient ingredient against cancer[J].Int J Mol Sci,2019,20(8):123-136.
[42] HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
[43] MARQUARDT J U,GOMEZ-QUIROZ L,CAMACHO L O A,et al.Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer[J].J Hepatol,2015,63(3):661-669.
[44] THACKER P C,KARUNAGARAN D.Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells[J].PLoS One,2015,10(3):e0120045.
[45] BAGAD A S,JOSEPH J A,BHASKARAN N,et al.Comparative evaluation of anti-inflammatory activity of curcuminoids,turmero-nes,and aqueous extract of Curcuma longa[J].Adv Pharmacol Sci,2013,2013:805756.
[46] CHANDRASEKARAN C V,SUNDARAJAN K,EDWIN J R,et al.Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction[J].Pharmacognosy Res,2013,5(2):71-79.
[47] RADOMSKA-LESNIEWSKA D M,OSIECKA-IWAN A,HYC A,et al.Therapeutic potential of curcumin in eye diseases[J].Cent Eur J Immunol,2019,44(2):181-189.
[48] MARCHIANI A,ROZZO C,FADDA A,et al.Curcumin and curcumin-like molecules:from spice to drugs[J].Curr Med Chem,2014,21(2):204-222.
[49] RADOMSKA-LES'NIEWSKA D M,HEVELKE A,SKOPIN'SKI P,et al.Reactive oxygen species and synthetic antioxidants as angiogenesis modulators:clinical implications[J].Pharmacol Rep,2016,68(2):462-471.
[50] LOBODA A,JAZWA A,GROCHOT-PRZECZEK A,et al.Heme oxygenase-1 and the vascular bed:from molecular mechanisms to therapeutic opportunities[J].Antioxid Redox Signal,2008,10(10):1767-1812.
[51] MOTTERLINI R,FORESTI R,BASSI R,et al.Curcumin,an antioxidant and anti-inflammatory agent,induces heme oxygenase-1 and protects endothelial cells against oxidative stress[J].Free Radic Biol Med,2000,28(8):1303-1312.
[52] GROVER M,SHAH K,KHULLAR G,et al.Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy[J].J Pharm Pharmacol,2019,71(5):725-732.
[53] ZHANG D W,FU M,GAO S H,et al.Curcumin and diabetes:a systematic review[J].Evid Based Complement Alternat Med,2013,2013:636053.
[54] KARLOWICZ-BODALSKA K,HAN S,FREIER J,et al.Curcuma longa as medicinal herb in the treatment of diabetic complication[J].Acta Pol Pharm,2017,74(2):605-610.
[55] PRENTKI M,MURTHY MADIRAJU S R M.Glycerolipid metabolism and signaling in health and disease[J].Endoc Rev,2008,29 (6):647-676.
[56] BABU P S,SRINIVASAN K.Hypolipidemic action of curcumin,the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats[J].Mol Cell Biochem,1997,166(1/2):169-175.
[57] ALWI I,SANTOSO T,SUYONO S,et al.The effect of curcumin on lipid level in patients with acute coronary syndrome[J].Acta Med Indones,2008,40(4):201-210.
[58] YOUSEF M I,EL-DEMERDASH F M,RADWAN F M E.Sodium arsenite induced biochemical perturbations in rats:ameliorating effect of curcumin[J].Food Chem Toxicol,2008,46(11):3506-3511.
[59] REUTENS A T.Epidemiology of diabetic kidney disease[J].Med Clin North Am,2013,97(1):1-18.
[60] BOONLA O,KUKONGVIRIYAPAN U,PAKDEECHOTE P,et al.Curcumin improves endothelial dysfunction and vascular remodeling in 2K-1C hypertensive rats by raising nitric oxide availability and reducing oxidative stress[J].Nitric Oxide,2014,42:44-53.
[61] NEERATI P,DEVDE R,GANGI A K.Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus[J].Phytother Res,2014,28(12):1796-1800.
[62] MIRZAEI H,SHAKERI A,RASHIDI B,et al.Phytosomal curcumin:a review of pharmacokinetic,experimental and clinical studies[J].Biomed Pharmacother,2017,85:102-112.
[63] LU P S,INBARAJ B S,CHEN B H.Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus[J].J Sci Food Agric,2017,98(1):51-63.

相似文献/References:

[1]曾松柏,张 梅,董化江,等.姜黄素对急性心肌梗死大鼠血管内皮生长因子及肿瘤坏死因子-α的影响[J].新乡医学院学报,2016,33(10):852.[doi:10.7683/xxyxyxb.2016.10.004]
 ZENG Song-bai,ZHANG Mei,DONG Hua-jiang,et al.Effect of curcumin on vascular endothelial growth factor and tumor necrosis factor-α in rats with acute myocardial infarction[J].Journal of Xinxiang Medical University,2016,33(10):852.[doi:10.7683/xxyxyxb.2016.10.004]

更新日期/Last Update: 2020-10-05