参考文献/References:
［1］ 冯冰.高频超声在桥本甲状腺炎与甲状腺功能亢进症鉴别诊断中的价值［J］.新乡医学院学报,2019,36(2):165-167,171.
［2］ SHIN D H,BAEK I C,KIM H J,et al.HLA alleles,especially amino-acid signatures of HLA-DPB1,might contribute to the molecular pathogenesis of early-onset autoimmune thyroid disease［J］.PLoS One,2019,14(5):e0216941.
［3］ RAMGOPAL S,RATHIKA C,PADMA M R,et al.Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in autoimmune thyroid disease［J］.Gene,2018,642:430-438.
［4］ TOMARI S,WATANABE M,INOUE N,et al.The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of anti-thyroid peroxidase antibody［J］.Endocr J,2017,64(10):1025-1032.
［5］ BRCˇIC＇ L,BARIC＇ A,GRACˇAN S,et al.Genome-wide association analysis suggests novel loci for Hashimoto′s thyroiditis［J］.J Endocrinol Invest,2019,42(5):567-576.
［6］ CHENG C W,YANG S F,WANG Y H,et al.Associations of secreted phosphoprotein 1 and B lymphocyte kinase gene polymorphisms with autoimmune thyroid disease［J］.Eur J Clin Invest,2019,49(3):e13065.
［7］ SONG R H,LI Q,JIA X,et al.Polymorphisms of FAM167A-BLK region confer risk of autoimmune thyroid disease［J］.DNA Cell Biol,2018,37(11):932-940.
［8］ JABROCKA-HYBEL A,SKALNIAK A,PIATKOWSKI J,et al.How much of the predisposition to Hashimoto′s thyroiditis can be explained based on previously reported associations［J］.J Endocrinol Invest,2018,41(12):1409-1416.
［9］ BLIDDAL S,NIELSEN C H,FELDT-RASMUSSEN U.Recent advances in understanding autoimmune thyroid disease:the tallest tree in the forest of polyautoimmunity［J］.F1000Res,2017,6:1776.
［10］ SAHA A,MUKHERJEE S,BHATTACHARJEE A,et al.Excess iodine-induced lymphocytic impairment in adult rats［J］.Toxicol Mech Methods,2019,29(2):110-118.
［11］ SARANAC L,ZIVANOVIC S,BJELAKOVIC B,et al.Why is the thyroid so prone to autoimmune disease［J］.Horm Res Paediatr,2011,75(3):157-165.
［12］ LUO Y,KAWASHIMA A,ISHIDO Y,et al.Iodine excess as an environmental risk factor for autoimmune thyroid disease［J］.Int J Mol Sci,2014,15(7):12895-12912.
［13］ 毕文,聂春磊,张杰武.碘通过影响细胞自噬参与甲状腺炎发病机制的研究［J］.国际免疫学杂志,2018,41(6):599-603.
［14］ FAREBROTHER J,ZIMMERMANN M B,ANDERSSON M.Excess iodine intake:sources,assessment,and effects on thyroid function［J］.Ann N Y Acad Sci,2019,1446(1):44-65.
［15］ KRYSIAK R,KOWALCZE K,OKOPIEN＇ B.Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto′s thyroiditis and low vitamin D status［J］.Pharmacol Rep,2019,71(2):367-373.
［16］ KRYSIAK R,SZKRO＇BKA W,OKOPIEN＇ B.The effect of vitamin D and selenomethionine on thyroid antibody titers,hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto′s thyroiditis:a pilot study［J］.Pharmacol Rep,2019,71(2):243-247.
［17］ GULERYUZ B,AKIN F,ATA M T,et al.Vitamin-D receptor (VDR) gene polymorphisms (TaqI,FokI) in Turkish patients with Hashimoto′s thyroiditis:relationship to the levels of vit-D and cytokines［J］.Endocr Metab Immune Disord Drug Targets,2016,16(2):131-139.
［18］ BOTELHO I M B,MOURA NETO A,SILVA C A,et al.Vitamin D in Hashimoto′s thyroiditis and its relationship with thyroid function and inflammatory status［J］.Endocr J,2018,65(10):1029-1037.
［19］ 朱昱.骨化三醇在桥本甲状腺炎甲状腺功能减退症患者中的应用［J］.新乡医学院学报,2017,34(8):709-711,716.
［20］ ZHANG Y,SHI L,ZHANG Q,et al.The association between cigarette smoking and serum thyroid stimulating hormone,thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents:a cross-sectional study in 10 cities［J］.PLoS One,2019,14(11):e0225435.
［21］ 贾雪莹,巩丽,黄高昇,等.人细小病毒B19与自身免疫性疾病病因学相关性研究进展［J］.细胞与分子免疫学杂志,2020,36(1):75-80.
［22］ CHIURI R M,MATRONOLA M F,DI GIULIO C,et al.Bartonella henselae infection associated with autoimmune thyroiditis in a child［J］.Horm Res Paediatr,2013,79:185-188.
［23］ SIEGMANN E M,MLLER H H O,LUECKE C,et al.Association of depression and anxiety disorders with autoimmune thyroi-ditis:a systematic review and meta-analysis［J］.JAMA Psy-chiatry,2018,75(6):577-584.
［24］ WANG S,BAIDOO S E,LIU Y,et al.T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto′s thyroiditis［J］.Clin Exp Immunol,2013,171(1):63-68.
［25］ WU Y,LI J Q,YAN B,et al.Oral exposure to dibutyl phthalate exacerbates chronic lymphocytic thyroiditis through oxidative stress in female Wistar rats［J］.Sci Rep,2017,7(1):15469.
［26］ MIHALJEVIC O,ZIVANCEVIC-SIMONOVIC S,MILOSEVIC-DJORDJEVIC O,et al.Apoptosis and genome instability in children with autoimmune diseases［J］.Mutagenesis,2018,33(5/6):351-357.
［27］ ERDOGAN M,KULAKSIZOGLU M,GANIDAGLI S,et al.Fas/FasL gene polymorphism in patients with Hashimoto′s thyroiditis in Turkish population［J］.J Endocrinol Invest,2017,40(1):77-82.
［28］ LIU Y,CHEN H,ZHANG L,et al.The association between thyroid injury and apoptosis,and alterations of bax,bcl-2,and caspase-3 mRNA/protein expression induced by nickel sulfate in wistar rats［J］.Biol Trace Elem Res,2020,195(1):159-168.
［29］ LUTY J,RUCKEMANN-DZIURDZIN~SKA K,WITKOWSKI J M,et al.Immunological aspects of autoimmune thyroid disease- complex interplay between cells and cytokines［J］.Cytokine,2019,116:128-133.
［30］ LI Q,WANG B,MU K,et al.The pathogenesis of thyroid autoimmune diseases:new T lymphocytes-cytokines circuits beyond the Th1-Th2 paradigm［J］.J Cell Physiol,2019,234(3):2204-2216.
［31］ 张晓序,朱莉,孙莉,等.IFN-γ上调桥本甲状腺炎Fas表达介导甲状腺破坏［J］.安徽医科大学学报,2017,52(6):806-809.
［32］ CHENG C W,WU C Z,TANG K T,et al.Simultaneous measurement of twenty-nine circulating cytokines and growth factors in female patients with overt autoimmune thyroid diseases［J］.Autoimmunity,2020,53(5):261-269
［33］ CUI X,LIU Y,WANG S,et al.Circulating exosomes activate dendritic cells and induce unbalanced CD4+ T cell differentiation in Hashimoto thyroiditis［J］.J Clin Endocrinol Metab,2019,104(10):4607-4618.
［34］ KAGAWA T,WATANABE M,INOUE N,et al.Increases of microRNA let-7e in peripheral blood mononuclear cells in Hashimoto′s disease［J］.Endocr J,2016,63(4):375-380.
［35］ CHEN Z,WANG Y,DING X,et al.The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients:a meta-analysis［J］.Endocr J，2020,67(3):317-326.
［36］ ZHAO J,CHEN Y,ZHAO Q,et al.Increased circulating Tfh17 and PD-1+ Tfh cells are associated with autoantibodies in Hashimoto′s thyroiditis［J］.Autoimmunity,2018,51(7):352-359.
［37］ HORIE I,ABIRU N,SAKAMOTO H,et al.Induction of autoimmune thyroiditis by depletion of CD4+CD25+ regulatory T cells in thyroiditis-resistant IL-17,but not interferon-gamma receptor,knockout nonobese diabetic-H2h4 mice［J］.Endocrinology,2011,152(11):4448-4454.
［38］ YAMADA H,ITOH M,HIRATSUKA I,et al.Circulating micro-RNAs in autoimmune thyroid diseases［J］.Clin Endocrinol (Oxf),2014,81(2):276-281.
［39］ ZHAO L J,ZHOU X,SHAN X,et al.Differential expression levels of plasma microRNA in Hashimoto′s disease［J］.Gene,2018,642:152-158.
［40］ OTSU H,WATANABE M,INOUE N,et al.Intraindividual variation of microRNA expression levels in plasma and peripheral blood mononuclear cells and the associations of these levels with the pathogenesis of autoimmune thyroid diseases［J］.Clin Chem Lab Med,2017,55(5):626-635.
［41］ VIRILI C,CENTANNI M.Does microbiota composition affect thyroid homeostasis［J］.Endocrine,2015,49(3):583-587.
［42］ HUANG T T,LAI J B,DU Y L,et al.Current understanding of gut microbiota in mood disorders:an update of human studies［J］.Front Genet,2019,10:98.
［43］ RUIZ L,DELGADO S,RUAS-MADIEDO P,et al.Bifidobacteria and their molecular communication with the immune system［J］.Front Microbiol,2017,8:2345.
［44］ BENE K,VARGA Z,PETROV V O,et al.Gut microbiota species can provoke both inflammatory and tolerogenic immune responses in human dendritic cells mediated by retinoic acid receptor alpha ligation［J］.Front Immunol,2017,8:427.
［45］ ZHAO F Y,FENG J,LI J,et al.Alterations of the gut microbiota in Hashimoto′s thyroiditis patients［J］.Thyroid,2018,28(2):175-186.
［46］ BACH J F.The hygiene hypothesis in autoimmunity:the role of pathogens and commensals［J］.Nat Rev Immunol,2018,18(2):105-120.