[1]郭 权,赵国安,林 飞,等.河南北部人群血脂年龄乘积与冠状动脉粥样硬化性心脏病的相关性[J].新乡医学院学报,2020,37(8):734-738.[doi:10.7683/xxyxyxb.2020.08.007]
 GUO Quan,ZHAO Guoan,LIN Fei,et al.Relationship between the product of blood lipid and age and coronary atherosclerotic heart disease in northern Henan[J].Journal of Xinxiang Medical University,2020,37(8):734-738.[doi:10.7683/xxyxyxb.2020.08.007]
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河南北部人群血脂年龄乘积与冠状动脉粥样硬化性心脏病的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年8
页码:
734-738
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Relationship between the product of blood lipid and age and coronary atherosclerotic heart disease in northern Henan
作者:
郭 权赵国安林 飞刘 懿常峥峥赵 晖阮梦瑶
(新乡医学院第一附属医院心脏中心,河南省心血管疾病临床数据与样本资源库工程研究中心,河南 卫辉 453100)
Author(s):
GUO QuanZHAO GuoanLIN FeiLIU YiCHANG ZhengzhengZHAO HuiRUAN Mengyao
(Heart Center of the First Affiliated Hospital of Xinxiang Medical University,Henan Engineering Research Center for Clinical Data and Biobank of Cardiovascular Diseases,Weihui 453100,Henan Province,China)
关键词:
冠状动脉粥样硬化性心脏病倾向性评分匹配低密度脂蛋白Gensini积分
Keywords:
coronary atherosclerotic heart diseasepropensity score matchinglow-density lipoproteinGensini score
分类号:
R541.4
DOI:
10.7683/xxyxyxb.2020.08.007
文献标志码:
A
摘要:
目的 探讨河南北部地区人群三酰甘油(TG)、载脂蛋白B(apoB)、低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(N-HDL-C)、脂蛋白(a)[Lp(a)]与年龄的乘积与冠状动脉粥样硬化性心脏病(CAHD)的相关性。方法 在河南省心血管病临床数据与样本资源库中选择2016年1月至2018年7月河南北部地区首次行冠状动脉造影的疑似CAHD患者2 921例为研究对象。根据冠状动脉造影结果将研究对象分为CAHD组(n=861)和非CAHD组(n=2 060),比较2组患者临床资料的差异。使用倾向性评分匹配消除混杂因素后,运用受试者工作特征曲线分析血脂年龄乘积与CAHD的关系;并运用多元线性回归分析血脂年龄乘积与Gensini积分的关系。结果 2组患者的性别、年龄、吸烟史、饮酒史、糖尿病史、高血压史、收缩压、肌酐、空腹血糖、TG、apoB、高密度脂蛋白胆固醇(HDL-C)、Lp(a)、TG·年龄、apoB·年龄、LDL-C·年龄、N-HDL-C·年龄、Lp(a)·年龄等比较差异均有统计学意义(P<0.05);2组患者的舒张压、总胆固醇、LDL-C、N-HDL-C比较差异均无统计学意义(P>0.05)。使用倾向性评分匹配消除了混杂因素后,无论是男性还是女性患者,CAHD组和非CAHD组TG·年龄、apoB·年龄、LDL-C·年龄、N-HDL-C·年龄、Lp(a)·年龄比较差异均有统计学意义(P<0.05);2组患者的吸烟史、饮酒史、糖尿病史、高血压史、收缩压、舒张压、肌酐及空腹血糖比较差异均无统计学意义(P>0.05)。男性人群中预测CAHD发生风险最准确的是apoB·年龄(AUC=0.613),女性人群中预测CAHD发生风险最准确的是TG·年龄(AUC=0.589)。多元线性回归分析结果显示,TG·年龄、apoB·年龄、LDL-C·年龄、N-HDL-C·年龄与Gensini积分呈正相关(P<0.05);当模型中存在apoB·年龄、LDL-C·年龄、N-HDL-C·年龄任1项时,TG·年龄与Gensini积分的相关性消失(P>0.05)。结论 血脂年龄乘积能更好地预测CAHD的发生及其病变严重程度。
Abstract:
Objective To investigate the relationship between the product of triglyceride(TG),apolipoprotein B(apoB),low-density lipoprotein cholesterol(LDL-C),non-high-density lipoprotein cholesterol(N-HDL-C),lipoprotein(a)[Lp (a)] and age and the coronary atherosclerotic heart disease(CAHD) in northern Henan.Methods A total of 2 921 suspected CAHD patients who were performed with coronary angiography for the first time in northen Henan from January 2016 to July,2017 were selected from the Henan Clinical Data and Sample Research Center as study objects.All patients were divided into CAHD group(n=861) and non-CAHD group(n=2 060) according to the results of coronary angiography and then the difference of the clinical data of patients were compared between the two groups.The receiver operating characteristic curve was used to analyze the relationship between the product of blood lipid and age and the CAHD after eliminating confounding factors by using propensity score matching;the relationship between the product of blood lipid and age and the Gensini score was analyzed by multiple linear regression.Results There were statistically significant differences in gender,age,smoking history,drinking history,diabetes history,hypertension history,systolic blood pressure,creatinine,fasting blood glucose,TG,apoB,high-density lipoprotein cholesterol(HDL-C),LP (a),TG·age,apoB·age,LDL-C·age,N-HDL-C·age,LP (a)·age between the two groups (P<0.05);there was no statistical difference in diastolic blood pressure,total cholesterol,LDL-C,N-HDL-C between the two groups(P>0.05).After eliminating confounding factors by using propensity score matching,there were statistically significant differences in TG·age,apoB·age,LDL-C·age,N-HDL-C·age,LP (a)·age between the CAHD group and the non-CAHD group in both female and male patients (P<0.05);there was no statistical difference in smoking history,drinking history,diabetes history,hypertension history,systolic blood pressure,diastolic blood pressure,creatinine and fasting blood glucose between the two groups in both female and male patients(P<0.05).The apoB· age[ area under curve(AUC)=0.613] was the best index in predicting the occurrence of CAHD in male patients,and TG · age (AUC=0.589) was the best index in predicting the occurrence of CAHD in female patients.Multiple linear regression analysis showed that the TG·age,apoB·age,LDL-C·age,N-HDL-C· age were positively correlated with Gensini score (P<0.05).When anyone of apoB·age,LDL-C·age and N-HDL-C·age existed in the model,the correlation between TG·age and Gensini score disappeared (P>0.05).Conclusion The product of blood lipid and age can better predict the occurrence and the severity of CAHD.

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更新日期/Last Update: 2020-08-05