参考文献/References:
［1］ MA J,MA Y,LIU X,et al.Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK,p38 and Akt signalling pathways ［J］.Biochem J,2015,469 (3):399-408.
［2］ KASHYAP D,MONDAL R,TULI H S,et al.Molecular targets of gambogic acid in cancer:recent trends and advancements ［J］.Tumour Biol,2016,37 (10):12915-12925.
［3］ DUAN N,HOU A J，LUAN B,et al.Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation,iNOS and NF-κB/p38 pathway ［J］.Exp Ther Med,2018,15 (2):1742-1748.
［4］ TANG W L,TANG W H,SZEITZ A,et al.Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery ［J］.Biomaterials,2018,166:13-26.
［5］ LIU N N,HUANG H B,XU L,et al.The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo ［J］.Toxicol Lett,2014,224 (3):333-340.
［6］ WANG J,ZHAO Q,QI Q,et al.Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP ［J］.J Cell Biochem,2011,112 (2):509-519.
［7］ LI X F,LIU S T,HUANG H B,et al.Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo ［J］.Cell Rep,2013,3 (1):211-222.
［8］ FELTH J,LESIAK-MIECZKOWSKA K,D′ARCY P,et al.Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system ［J］.Invest New Drugs,2013,31 (3):587-598.
［9］ SHI X P,CHEN X,LI X F,et al.Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation ［J］.Clin Cancer Res,2014,20 (1):151-163.
［10］ SHI X P,LAN X Y,CHEN X,et al.Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition ［J］.Sci Rep,2015,5:9694.DOI:10.1038/srep09694.
［11］ LIU S T,ZHAO C G,YANG C S,et al.Gambogic acid suppresses pressure overload cardiac hypertrophy in rats ［J］.Am J Cardiovasc Dis,2013,3 (4):227-238.
［12］ ZHAO C G,LIU S T,YANG C S,et al.Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-kappaB pathway ［J］.Am J Cardiovasc Dis,2013,3 (3):135-145.
［13］ WANG X,CHEN W T.Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation,angiogenesis and metastasis ［J］.Anticancer Agents Med Chem,2012,12 (8):994-1000.
［14］ ALUKSANASUWAN S,PEERAPEN P,PLUMWORASAWAT S,et al.Highly effective methods for expression/purification of recombinant human HSP90 and its four distinct (N-LR-M-C) domains ［J］.Anal Biochem,2020,590:113518.DOI:10.1016/j.ab.2019.113518.
［15］ ZHANG L R,YI Y T,CHEN J J,et al.Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells ［J］.Biochem Biophys Res Commun,2010,403 (3/4):282-287.
［16］ DAVENPORT J,MANJARREZ J R,PETERSON L,et al.Gambogic acid,a natural product inhibitor of Hsp90 ［J］.J Nat Prod,2011,74 (5):1085-1092.
［17］ YIM K H,PRINCE T L,QU S,et al.Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90beta ［J］.Proc Natl Acad Sci USA,2016,113 (33):E4801- E4809.
［18］ JOHNSEN K B,BURKHART A,THOMSEN L B,et al.Targeting the transferrin receptor for brain drug delivery ［J］.Prog Neurobiol,2019,181:101665.DOI:10.1016/j.pneurobio.2019.101665.
［19］ WANG J J,GENG Y Y,ZHANG Y P,et al.Bacterial magnetosomes loaded with doxorubicin and transferrin improve targeted therapy of hepatocellular carcinoma ［J］.Nanotheranostics,2019,3 (3):284-298.
［20］ FU M P,HE Q,GUO Z L,et al.Therapeutic bispecific T-cell engager antibody targeting the transferrin receptor ［J］.Front Immunol,2019,10:1396.DOI:10.3389/fimmu.2019.01396.
［21］ KASIBHATLA S,JESSEN K A,MALIARTCHOUK S,et al.A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid ［J］.Proc Natl Acad Sci USA,2005,102 (34):12095-12100.
［22］ YANG Y,YANG L,YOU Q D,et al.Differential apoptotic induction of gambogic acid,a novel anticancer natural product,on hepatoma cells and normal hepatocytes ［J］.Cancer Lett,2007,256 (2):259-266.
［23］ ZHU X L,ZHANG H M,LIN Y,et al.Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors ［J］.J Chemother,2009,21 (6):666-672.
［24］ JIAN J L,YANG Q,HUANG X.Src regulates Tyr20 phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival ［J］.J Biol Chem,2011,286 (41):35708-35715.
［25］ DEHSHAHRI A,ASHRAFIZADEH M,GHASEMIPOUR AFSHAR E,et al.Topoisomerase inhibitors:pharmacology and emerging nanoscale delivery systems ［J］.Pharmacol Res,2019,151:104551.DOI:10.1016/j.phrs.2019.104551.
［26］ JUN K Y,KWON Y.Proposal of dual Inhibitor targeting ATPase domains of topoisomerase II and heat shock protein 90 ［J］.Biomol Ther (Seoul),2016,24 (5):453-468.
［27］ QIN Y X,MENG L H,HU C X,et al.Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain ［J］.Mol Cancer Ther,2007,6 (9):2429-2440.
［28］ RODRIGUES-FERREIRA S,MOLINA A,NAHMIAS C.Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer ［J］.Breast Cancer Res Treat,2020,179(2):267-273.
［29］ CHEN J,GU H Y,LU N,et al.Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells ［J］.Life Sci,2008,83 (3/4):103-109.
［30］ BILGILI H,BIALAS A J,GORSKI P,et al.Telomere abnormalities in the pathobiology of idiopathic pulmonary fibrosis ［J］.J Clin Med,2019,8 (8):1232.
［31］ CHEN X,TANG W J,SHI J B,et al.Therapeutic strategies for targeting telomerase in cancer ［J］.Med Res Rev,2020，40(2):532-585.
［32］ GURUNG R L,LIM S N,LOW G K,et al.MST-312 alters telomere dynamics,gene expression profiles and growth in human breast cancer cells ［J］.J Nutrigenet Nutrigenomics,2014,7 (4/5/6):283-298.
［33］ GANESAN K,XU B.Telomeres inhibitors from natural products and their anticancer potential ［J］.Int J Mol Sci,2017,19 (1):13.
［34］ WU Z Q,GUO Q L,YOU Q D,et al.Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells ［J］.Biol Pharm Bull,2004,27 (11):1769-1774.
［35］ YU J,GUO Q L,YOU Q D,et al.Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells ［J］.Cancer Chemother Pharmacol,2006,58 (4):434-443.
［36］ ZHOU Y Q,LI W C,ZHANG X X,et al.Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics ［J］.Chem Commun (Camb),2016,52 (97):14035-14038.
［37］ YANG J,LI C L,DING L,et al.Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain ［J］.J Nat Prod,2012,75 (6):1108-1116.
［38］ TIAN C P,SUN R,LIU K K,et al.Multiplexed thiol reactivity profiling for target discovery of electrophilic natural products ［J］.Cell Chem Biol,2017,24 (11):1416-1427.
［39］ PANDEY M K,SUNG B,AHN K S,et al.Gambogic acid,a novel ligand for transferrin receptor,potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway ［J］.Blood,2007,110 (10):3517-3525.
［40］ GENG J,XIAO S Y,ZHENG Z H,et al.Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro ［J］.Inflamm Res,2013,62 (2):165-172.
［41］ PALEMPALLI U D,GANDHI U,KALANTARI P,et al.Gambogic acid covalently modifies IkappaB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages ［J］.Biochem J,2009,419 (2):401-409.
［42］ ZHAO K,ZHANG S,SONG X M,et al.Gambogic acid suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition ［J］.Oncotarget,2017,8 (16):27120-27136.
［43］ REN J,LI L X,WANG Y,et al.Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated RAW264.7 cells ［J］.Biomed Pharmacother,2019,109:555-562.
［44］ TANG Q S,LU M D,ZHOU H,et al.Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity ［J］.Oncol Lett,2017,13 (1):384-388.
［45］ CASCAO R,VIDAL B,RAQUEL H,et al.Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis［J］.Mediators Inflamm,2014,2014:195327.DOI:10.1155/2014/195327.
［46］ WEN J L,PEI H Y,WANG X H,et al.Gambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation ［J］.J Dermatol Sci,2014,74 (3):242-250.
［47］ LI N,ZHOU H,TANG Q.miR-133:a suppressor of cardiac remodeling［J］.Front Pharmacol,2018,9:903.DOI:10.3389/fphar.2018.00903.
［48］ LAI H C,CHANG Q Y,HSIEH C L.Signal transduction pathways of acupuncture for treating some nervous system diseases ［J］.Evid Based Complement Alternat Med,2019,2019:2909632.DOI:10.1155/2019/2909632.
［49］ CAO J,WANG J S,REN X H,et al.Spinal sample showing p-JNK and p38 associated with the pain signaling transduction of glial cell in neuropathic pain ［J］.Spinal Cord,2015,53 (2):92-97.
［50］ FU Q,LI C J,YU L H.Gambogic acid inhibits spinal cord injury and inflammation through suppressing the p38 and Akt signaling pathways ［J］.Mol Med Rep,2018,17 (1):2026-2032.
［51］ MA J,HUANG K,MA Y,et al.Gambogic acid inhibits LPS-induced macrophage pro-inflammatory cytokine production mainly through suppression of the p38 pathway ［J］.Iran J Basic Med Sci,2018,21 (7):717-723.
［52］ PAN H,LU L Y,WANG X Q,et al.Gambogic acid Induces cell apoptosis and inhibits MAPK pathway in PTEN-/-/p53-/- prostate cancer cells in vitro and ex vivo ［J］.Chin J Integr Med,2018,24 (2):109-116.
［53］ XU L F,LAO Y Z,ZHAO Y H,et al.Screening active compounds from garcinia species native to china reveals novel compounds targeting the STAT/JAK signaling pathway ［J］.Biomed Res Int,2015,2015:910453.DOI:10.1155/2015/910453.
［54］ PRASAD S,PANDEY M K,YADAY V R,et al.Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1:potential role in proliferation and apoptosis ［J］.Cancer Prev Res (Phila),2011,4 (7):1084-1094.
［55］ WAN L,ZHANG Q,WANG S,et al.Gambogic acid impairs tumor angiogenesis by targeting YAP/STAT3 signaling axis ［J］.Phytother Res,2019,33 (5):1579-1591.
［56］ AOYAGI T,MATSUI T.Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure ［J］.Curr Pharm Des,2011,17 (18):1818-1824.
［57］ CHEN H,ZHOU L,WU X,et al.The PI3K/AKT pathway in the pathogenesis of prostate cancer ［J］.Front Biosci (Landmark Ed),2016,21:1084-1091.
［58］ LU L,TANG D,WANG L,et al.Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways ［J］.Acta Pharmacol Sin,2012,33 (4):531-541.
［59］ WANG F,ZHANG W,GUO L T,et al.Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells ［J］.Cancer Sci,2014,105 (8):1063-1070.
［60］ ZHOU Z L,MA J.Gambogic acid suppresses colon cancer cell activity in vitro ［J］.Exp Ther Med,2019,18 (4):2917-2923.
［61］ YANG Y,SUN X D,YANG Y H,et al.Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway ［J］.Tumour Biol,2016,37 (2):1853-1862.
［62］ CUI J Y,GONG R,HU S Q,et al.Gambogic acid ameliorates diabetes-induced proliferative retinopathy through inhibition of the HIF-1α/VEGF expression via targeting PI3K/AKT pathway ［J］.Life Sci,2018,192:293-303.
［63］ CASCAO R,VIDAL B,RAQUEL H,et al.Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis ［J］.Mediators Inflamm,2014,2014:195327.DOI:10.1155/2014/195327.
［64］ WANG Q L,YANG D Z,LYU C X.Anti-inflammatory effects of gambogic acid in murine collagen-induced arthritis through PI3K/Akt signaling pathway ［J］.Mol Med Rep,2018,17 (3):4791-4796.
［65］ LI G Q,ZHANG Y,LIU D,et al.PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis ［J］.Mol Cell Biochem,2013,372 (1/2):221-231.
［66］ WU X D,LONG L,LIU J,et al.Gambogic acid suppresses inflammation in rheumatoid arthritis rats via PI3K/Akt/mTOR signaling pathway ［J］.Mol Med Rep,2017,16 (5):7112-7118.
［67］ LIU Q,SHAN P,LI H.Gambogic acid prevents angiotensin II-induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K/Akt/mTOR and NF-κB signaling pathways ［J］.Mol Med Rep,2019,19 (2):1396-1402.
［68］ HE M Y,RO L,LIU J,et al.Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells ［J］.J Biomed Mater Res A,2017,105 (2):475-490.