[1]陈萌珂,张黎军,王园春,等.血清可溶性细胞间黏附分子-1水平与急性脑梗死患者血管性认知障碍的相关性[J].新乡医学院学报,2020,37(7):666-669.[doi:10.7683/xxyxyxb.2020.07.016]
　CHEN Mengke,ZHANG Lijun,WANG Yuanchun,et al.Correlation between serum soluble intercellular adhesion molecule-1 level and vascular cognitive impairment in patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2020,37(7):666-669.[doi:10.7683/xxyxyxb.2020.07.016]
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血清可溶性细胞间黏附分子-1水平与急性脑梗死患者血管性认知障碍的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年7
页码:
666-669
栏目:
临床研究
出版日期:
2020-07-05

文章信息/Info

Title:
Correlation between serum soluble intercellular adhesion molecule-1 level and vascular cognitive impairment in patients with acute cerebral infarction
作者:
陈萌珂1; 张黎军1; 王园春1; 任耀鑫1; 袁　彬1; 2
（1.新乡医学院第一附属医院神经内科，河南　卫辉　453100；2.河南省神经修复重点实验室，河南　卫辉　453100）
Author(s):
CHEN Mengke1; ZHANG Lijun1; WANG Yuanchun1; REN Yaoxin1; YUAN Bin1; 2
（1.Department of Neurology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100，Henan Province，China；2.The Key Neurorepair Laboratory of Henan Province，Weihui 453100，Henan Province,China）
关键词:
急性脑梗死; 可溶性细胞间黏附分子-1; 血管性认知障碍
Keywords:
acute cerebral infarction; soluble intercellular adhesion molecule-1; vascular cognitive impairment
分类号:
R743.3
DOI:
10.7683/xxyxyxb.2020.07.016
文献标志码:
A
摘要:
目的　探讨血清可溶性细胞间黏附分子-1（sICAM-1）水平与急性脑梗死患者血管性认知障碍（VCI）的相关性。方法　选择2018年1月至2019年6月新乡医学院第一附属医院收治的204例首次发病急性脑梗死患者为研究对象,于脑梗死发病后3个月采用中文版简易智能精神状态量表(MMSE)进行测评,根据测评结果分为VCI组(n=105）和无VCI组（n=99）。患者均于入院次日清晨抽取空腹肘静脉血5 mL，采用酶联免疫吸附试验法检测血清sICAM-1水平；采用受试者工作特征（ROC）曲线评价血清sICAM-1水平预测VCI的敏感度、特异度和准确度，计算Youden指数，确定最佳截断值；采用Spearman相关分析血清sICAM-1水平与VCI患者MMSE评分的相关性。结果　VCI组患者血清sICAM-1水平显著高于无VCI组（P<0.01）。VCI组患者中，发生轻度认知障碍54例，中度认知障碍34例，重度认知障碍17例；轻度、中度、重度认知障碍患者血清sICAM-1水平比较差异有统计学意义（F=48.441，P<0.01），中度、重度认知障碍患者血清sICAM-1水平显著高于轻度认知障碍患者(P<0.01），重度认知障碍患者血清sICAM-1水平显著高于中度认知障碍患者（P<0.01）。sICAM-1诊断VCI的曲线下面积为0.895（95％可信区间为0.849～0.942，P<0.01），血清sICAM-1水平为307.59 μg·L-1时获得最大Youden指数为0.688，血清sICAM-1水平预测脑梗死患者VCI的敏感度为98.1％，特异度为70.7％。血清sICAM-1水平与VCI患者MMSE评分呈显著负相关（r＝-0.646，P<0.01）。结论　急性脑梗死VCI患者血清sICAM-1水平升高，血清sICAM-1水平与VCI患者MMSE评分呈显著负相关，血清sICAM-1水平可在一定程度上预测急性脑梗死患者发生VCI的可能。
Abstract:
Objective　To investigate the correlation between the level of serum soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cognitive impairment (VCI) in patients with acute cerebral infarction．Methods　Two hundred and four patients with the first onset acute cerebral infarction in the First Affiliated Hospital of Xinxiang Medical University from January 2018 to June 2019 were selected as the subjects．The patients were evaluated by Chinese version of minimum mental state examination (MMSE) at three months after onset of cerebral infarction．According to the evaluation results，the patients were divided into VCI group (n=105) and non-VCI group (n=99)．Five milliliters of fasting elbow venous blood was taken from patients in the next morning after admission．The level of serum sICAM-1 was detected by enzyme-linked immunosorbent assay．The sensitivity，specificity and accuracy of the serum sICAM-1 level in predicting VCI were evaluated by receiver operating characteristic curve(ROC)，and the Youden index was calculated to determine the best cut-off value．The correlation between the serum sICAM-1 level and MMSE score in patients with VCI was analyzed by spearman correlation．Results　The level of serum sICAM-1 in the VCI group was significantly higher than that in the non-VCI group (P<0.01)．In the VCI group，there were 54 cases of mild cognitive impairment，34 cases of moderate cognitive impairment and 17 cases of severe cognitive impairment．There was statistically significant difference in the level of serum sICAM-1 among the patients with mild，moderate and severe cognitive impairment (F=48.441，P<0.01)．The level of serum sICAM-1 in the patients with moderate cognitive impairment and severe cognitive impairment was significantly higher than that in the patients with mild cognitive impairment，and the level of serum sICAM-1 in the patients with severe cognitive impairment was significantly higher than that in the patients with moderate cognitive impairment (P<0.01)．The area under the curve of sICAM-1 in diagnosing VCI was 0.895 (95% confidence interval：0.84-0.942，P<0.01)，the maximum Youden index was 0.688 when the level of serum sICAM-1 was 307.59 μg·L-1，and the sensitivity and specificity of the serum sICAM-1 level in predicting VCI of patients with cerebral infarction were 98.1% and 70.7%．The level of sICAM-1 was negatively correlated with MMSE score in the patients with VCI (r=-0.646,P<0.01)．Conclusion　The level of serum sICAM-1 increased in acute cerebral infarction patients with VCI．The level of serum sICAM-1 is negatively correlated with MMSE score in patients with VCI．The level of serum sICAM-1 can predict the possibility of VCI in patients with acute cerebral infarction to certain extent．

参考文献/References:

［1］　孙允芹，王耀峰，郭寒冰，等.肝细胞生长因子重组腺病毒对高血压高血脂大鼠学习记忆能力及海马凋亡蛋白表达的影响［J］.新乡医学院学报，2018，35（1）:26-29．
［2］　于博，崔娜，许洁，等.头电针对非痴呆型血管性认知障碍的疗效及其对事件相关电位的影响［J］.世界中医药，2020，15（4）:632-636.
［3］　张红豆，刘晓加，艾佩莹，等.卒中后失语患者认知功能障碍的康复特点及影响因素［J］．中华行为医学与脑科学杂志，2017，26（6）：519-523．
［4］　DU S Q，WANG X R，ZHU W，et al.Acupuncture inhibits TXNIP associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats［J］.CNS Neurosci Ther，2018，24（1）：39-46．
［5］　苑杰，姜伟时，刘颖，等.血管性抑郁的生物学机制研究进展［J］.新乡医学院学报，2019，36（12）:1197-1200.
［6］　张录清，陈频，李宁，等.丁苯酞注射液对急性脑梗死患者神经功能及血清炎症因子的影响［J］.河北医科大学学报，2016，37（10）：1162．
［7］　DENG L，WAN H T，ZHOU H F，et al.Protective effect of hydroxysafflor yellow a alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat:a PET study using 18F-fuorodeoxyglucose［J］.Eur J Pharmacol，2018，8（25）：119-132.
［8］　彭斌，刘鸣，崔丽英.与时俱进的新指南：《中国急性缺血性脑卒中诊治指南2018》解读［J］.中华神经科杂志，2018，51（9）：657-659.
［9］　郗欧，焦富英，马进，等.头皮针联合康复训练对脑卒中后轻度认知障碍患者脑血流动力学及血管内皮功能的影响［J］.世界中医药，2019，14（2）:477-480.
［10］　CIUCA C，FORTUNA D，FERRARI S，et al.Cognitive and quality of lifetrajectory after either surgicalor transcatheteraor-ticvalver eplacement in high-risk patients［J］.G Ital Cardiol(Rome)， 2016，17（12 suppl 1）：15-21.
［11］　王陇德，刘建民，杨弋，等.《中国脑卒中防治报告2017》概要［J］.中国脑血管病杂志，2018，15（11）：611-617.
［12］　KLINE R，WONG E，HAILE M，et al.Peri-operative inflammatory cytokines in plasma of the elderly correlate in prospective study with postoperative changes in cognitive test scores［J］.Int J Anesthesiol Res，2016，4（8）：313-21.
［13］　金梅，李晓凤.糖尿病视网膜病变患者血清中细胞因子及视网膜中央动脉血流动力学的变化［J］.眼科新进展，2019，39（5）:453-455.
［14］　白润爱，康娟，古联.疏血通对急性脑梗塞患者脑血流动力学、血清sICAM-1、IL-6、TNF-α的影响［J］．昆明医科大学学报，2016，37（9）：58-61．
［15］　周洁，吉玲，王新华，等.细胞间黏附分子-1在支气管哮喘儿童支气管黏膜中的表达及其对支气管上皮细胞凋亡的影响［J］.新乡医学院学报，2019，26（2）：126-135.
［16］　关天翔，秦秀德，林松俊，等．脑髓康对血管性痴呆模型大鼠认知功能的影响［J］．医药导报，2018，37（7）：809-812．
［17］　丁鹏，李春娟．β受体阻滞剂联合他汀类药物治疗慢性心衰临床观察［J］．陕西医学杂志，2017，46（2）：264-272.

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更新日期/Last Update: 2020-07-05