[1]李艳川,石紫云,任朵梅,等.黄芪多糖对放射治疗和化学治疗宫颈癌患者免疫功能和不良反应的影响[J].新乡医学院学报,2020,37(6):580-583.[doi:10.7683/xxyxyxb.2020.06.018]
　LI Yanchuan,SHI Ziyun,REN Duomei,et al.Effects of astragalin on the immune function and adverse reactions in patients with cervical cancer undergoing radiotherapy and chemotherapy[J].Journal of Xinxiang Medical University,2020,37(6):580-583.[doi:10.7683/xxyxyxb.2020.06.018]
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黄芪多糖对放射治疗和化学治疗宫颈癌患者免疫功能和不良反应的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年6
页码:
580-583
栏目:
临床研究
出版日期:
2020-06-05

文章信息/Info

Title:
Effects of astragalin on the immune function and adverse reactions in patients with cervical cancer undergoing radiotherapy and chemotherapy
作者:
李艳川; 石紫云; 任朵梅; 邓小艳
（陕西省人民医院妇产科，陕西　西安　710068）
Author(s):
LI Yanchuan; SHI Ziyun; REN Duomei; DENG Xiaoyan
(Department of Obstetrics and Gynecology,Shaanxi Provincial People′s Hospital,Xi′an 710068,Shaanxi Province,China)
关键词:
宫颈癌; 黄芪多糖; 化学治疗; 放射治疗; 不良反应; 免疫抑制
Keywords:
cervical cancer; astragalin; chemotherapy; radiotherapy; adverse reaction; immunosuppression
分类号:
R737.33
DOI:
10.7683/xxyxyxb.2020.06.018
文献标志码:
A
摘要:
目的　探讨黄芪多糖对放射治疗和化学治疗宫颈癌患者免疫功能和不良反应的影响。方法　选择2016年5月至2018年5月陕西省人民医院收治的130例宫颈癌患者为研究对象，根据随机数表法均分为对照组与观察组，每组65例。2组患者均给予相同的化学治疗和放射治疗方案，在此基础上，观察组患者给予黄芪多糖治疗。分别于治疗前及治疗后检测2组患者CD3+、CD4+、CD8+、CD4+/CD8+、调节性T细胞（Treg）、髓源性抑制细胞（MDSC）、白细胞计数（WBC）、红细胞计数（RBC）、血小板计数（BPC）水平。治疗后评估2组患者临床疗效，并观察2组患者不良反应发生情况。结果　观察组和对照组患者治疗总有效率分别为64.62%（42/65）、44.62%（29/65），观察组患者治疗总有效率高于对照组（Z=5.245，P＜0.05）。治疗前2组患者CD3+、CD4+、CD8+、CD4+/CD8+、Treg、MDSC水平比较差异无统计学意义（P＞0.05）；对照组患者治疗后Treg、MDSC水平低于治疗前（P＜0.05），对照组患者治疗前后CD3+、CD4+、CD8+、CD4+/CD8+水平比较差异无统计学意义（P＞0.05）；与治疗前比较，观察组患者治疗后CD3+、CD4+、CD4+/CD8+水平升高，CD8+、Treg、MDSC水平降低（P＜0.05）；治疗后，观察组患者CD3+、CD4+、CD4+/CD8+水平高于对照组，CD8+、Treg、MDSC水平低于对照组（P＜0.05）。治疗前2组患者WBC、RBC、BPC比较差异无统计学意义（P＞0.05），2组患者治疗后WBC、RBC、BPC低于治疗前（P＜0.05）；治疗后，观察组患者WBC、RBC、BPC多于对照组（P＜0.05）。观察组患者白细胞减少、血小板减少、骨髓抑制、肝功能异常、肾功能异常及胃肠道反应发生率均低于对照组（P＜0.05）。结论　黄芪多糖可显著改善放射治疗和化学治疗宫颈癌患者的免疫功能，减少不良反应，提高治疗效果。
Abstract:
Objective　To investigate the effect of astragalin on the immune function and adverse reactions in patients with cervical cancer undergoing radiotherapy and chemotherapy.Methods　A total of 130 patients with cervical cancer admitted to Shaanxi People′s Hospital from May 2016 to May 2018 were selected as the study objects,and they were divided into control group and observation group according to the random number table method,with 65 cases in each group.The patients in the two groups were treated with the same chemotherapy and radiotherapy regimen.On this basis,the patients in the observation group were treated with astragalin.The levels of CD3+　,CD4+　,CD8+　,CD4+　/CD8+　,regulatory T cell (Treg),myeloid-derived suppressor cell (MDSC),white blood cell count (WBC),red blood cell count (RBC) and blood platelet count (BPC) were detected before and after treatment.The clinical effect of the patients in the two groups was evaluated after treatment,and the adverse reactions were observed.Results　The total effective rate in the observation group and the control group was 64.62% (42/65) and 44.62% (29/65),respectively.The total effective rate in the observation group was higher than that in the control group (Z=5.245,P<0.05).There was no significant difference in the levels of CD3+　,CD4+　,CD8+　,CD4+　/CD8+　,Treg and MDSC between the two groups before treatment (P>0.05).The levels of Treg and MDSC after treatment were lower than those before treatment in the control group (P<0.05),but there was no significant difference in the levels of CD3+　,CD4+　,CD8+　,CD4+　/CD8+　 before and after treatment (P>0.05).Compared with before treatment,the levels of CD3+　,CD4+　,CD4+　/CD8+　 increased,while the levels of CD8+　,Treg and MDSC decreased in the observation group (P<0.05).After treatment,the levels of CD3+　,CD4+　 and CD4+　/CD8+　 in the observation group were higher than those in the control group,and the levels of CD8+　,Treg and MDSC in the observation group were lower than those in the control group (P<0.05).There was no significant difference in WBC,RBC and BPC between the two groups before treatment (P>0.05).The WBC,RBC and BPC of the patients after treatment were lower than those before treatment in the two groups (P<0.05).The WBC,RBC and BPC of the patients in the observation group were higher than those in the control group after treatment (P<0.05).The incidences of leucopenia,thrombocytopenia,myelosuppression,liver function abnormality,renal function abnormality and gastrointestinal reaction of the patients in the observation group were lower than those in the control group (P<0.05).Conclusion　Astragalin can significantly improve the immune function of patients with cervical cancer undergoing radiotherapy and chemotherapy,reduce adverse reactions and improve the therapeutic effect.

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更新日期/Last Update: 2020-06-05