[1]徐国卫,杨亚红,常小敬,等.丁苯酞治疗大脑中动脉狭窄所致急性脑梗死疗效观察[J].新乡医学院学报,2020,37(5):481-483.[doi:10.7683/xxyxyxb.2020.05.019]
　XU Guowei,YANG Yahong,CHANG Xiaojing,et al.Clinical effect of butylphthalide for acute cerebral infarction caused by middle cerebral artery stenosis[J].Journal of Xinxiang Medical University,2020,37(5):481-483.[doi:10.7683/xxyxyxb.2020.05.019]
点击复制

丁苯酞治疗大脑中动脉狭窄所致急性脑梗死疗效观察
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年5
页码:
481-483
栏目:
临床研究
出版日期:
2020-05-05

文章信息/Info

Title:
Clinical effect of butylphthalide for acute cerebral infarction caused by middle cerebral artery stenosis
作者:
徐国卫; 杨亚红; 常小敬; 刘　欣; 王新成; 高　兰
（郑州大学附属郑州中心医院神经内科，河南　郑州　450007）
Author(s):
XU Guowei; YANG Yahong; CHANG Xiaojing; LIU Xin; WANG Xincheng; GAO Lan
（Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University，Zhengzhou 450007,Henan Province,China）
关键词:
丁苯酞; 大脑中动脉狭窄; 急性脑梗死
Keywords:
butylphthalide; middle cerebral artery stenosis; acute cerebral infarction
分类号:
R743.33
DOI:
10.7683/xxyxyxb.2020.05.019
文献标志码:
A
摘要:
目的　探讨丁苯酞治疗大脑中动脉狭窄所致急性脑梗死的临床效果。方法　选择郑州大学附属郑州中心医院2017年8月至2019年8月收治的大脑中动脉狭窄所致急性脑梗死患者88例为研究对象，根据治疗方法分为观察组和对照组，每组44例。2组患者均给予常规治疗，在此基础上，对照组患者给予依达拉奉治疗，观察组患者在对照组治疗的基础上给予丁苯酞，连续治疗4周。 治疗前后检测2组患者血清C-反应蛋白（CRP）和白细胞介素-4（IL-4）水平，采用美国国立卫生研究院脑卒中量表（NIHSS）和Barthel指数评分量表评估患者神经功能缺损情况和日常生活活动能力，比较2组患者的治疗效果及不良反应发生情况。结果　治疗前2组患者CRP、IL-4水平及NIHSS、Barthel评分比较差异无统计学意义（P＞0.05）。治疗后，2组患者CRP、IL-4水平均较治疗前下降（P＜0.05）；且观察组患者CRP、IL-4水平低于对照组（P＜0.05）。与治疗前比较，治疗后2组患者NIHSS评分下降，Barthel评分升高（P＜0.05）。与对照组比较，治疗后观察组患者NIHSS评分下降，Barthel评分升高（P＜0.05）。对照组和观察组患者治疗总有效率分别为77.27%（34/44）和95.45%（42/44），观察组患者治疗总有效率高于对照组（χ2=6.175，P＜0.05）。2组患者均未发生明显的过敏反应、胃肠道反应和出血倾向。结论　大脑中动脉狭窄所致急性脑梗死患者加用丁苯酞治疗更有助于改善炎症因子水平和神经功能，效果显著，安全性高。
Abstract:
Objective　To explore the therapeutic effect of butylphthalide in treatment of acute cerebral infarction caused by middle cerebral artery stenosis.Methods　Eighty-eight patients with acute cerebral infarction caused by middle cerebral artery stenosis admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from August 2017 to August 2019 were selected as observation subjects.According to the treatment method,they were divided into observation group and control group,with 44 cases in each group.All patients were given routine therpy,based on this,the patients in the control group were given edaravone treatment,and the patients in the observation group were given butylphthalide on the basis of treatment of the control group;the patients in the two groups were treated for 4 consecutive weeks.The C-reactive protein (CRP) and interleukin-4 (IL-4) levels were detected before and after treatment.The nerve functional defects and daily living activities of the patients in the two groups were evaluated by the national institutes of health stroke scale (NIHSS) and Barthel index score scale,respectively.The treatment effects and adverse reactions of patients in the two groups were compared.Results　There was no significant difference in the CRP,IL-4 levels and NIHSS,Barthel scores between the two groups before treatment (P>0.05).After treatment,the CRP and IL-4 levels in the two groups were lower than those before treatment (P＜0.05);the levels of CRP and IL-4 in the observation group were lower than those in the control group (P＜0.05).The NIHSS scores in the two groups after treatment were lower,while the Barthel scores were higher than those before treatment (P＜0.05).Compared with the control group,the NIHSS scores in the observation group were lower and the Barthel scores were higher after treatment（P＜0.05）.The total effective rate of patients in the control group and the observation group was 77.27% (34/44) and 95.45% (42/44),respectively.The total effective rate of patients in the observation group was higher than that in the control group (χ2　=6.175,P＜0.05).There was no significant allergic reaction,gastrointestinal reaction or bleeding tendency in both groups.Conclusion　Butylphthalide can improve the level of inflammatory factors and nerve function in patients with acute cerebral infarction caused by middle cerebral artery stenosis with significant effect and high safety.

参考文献/References:

［1］　刘晓鹏.依那普利叶酸辅助治疗对急性脑梗死合并高血压患者预后的影响［J］.慢性病学杂志,2017,19(7):808-809.
［2］　邬刚，李建辉，战丽萍，等.丁苯酞注射液对伴有认知障碍的脑梗死急性期患者脑血流灌注和认知功能的影响［J］.中华神经医学杂志,2018，17(5):484-490.
［3］　HUANG L,WANG S,MA F,et al.From stroke to neurodegenerative diseases:the multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives ［J］.Pharmacol Res,2018,135:201-211.
［4］　马荣，李瑞卿.丁苯酞在超早期脑梗死患者溶栓治疗中的作用［J］.山东医药,2018，58(21):80-82.
［5］　陈月，王月祥，鲁宛灵，等.丁苯酞软胶囊治疗急性脑梗死的疗效和安全性的系统评价［J］.中国医院用药评价与分析,2018，18(8):1087-1089,1093.
［6］　王玉东.静脉溶栓联合动脉取栓治疗急性缺血性脑卒中的疗效及安全性［J］.新乡医学院学报,2019,36(8):764-767.
［7］　陈娟.丁苯酞对急性脑梗死患者神经功能及血清S100B、同型半胱氨酸和血管生成素-1水平的影响察［J］.新乡医学院学报,2018,35(6):498-501．
［8］　周辉，周少珑，朱雄.丁苯酞联合依达拉奉治疗急性脑梗死疗效及对患者VEG、MMP-9 、EPCs水平的影响［J］.河北医药,2018，40(13):2024-2026.
［9］　ZHANG P,XU R,GUO Y,et al.DL-3-n-butylphthalide promotes dendrite development in cortical neurons subjected to oxygen-glucose deprivation/reperfusion［J］.Cell Biol Int,2018,42(8):1041-1049.
［10］　张轶美，刘霄，韩毅，等.丁苯酞联合血塞通对急性脑梗死患者认知功能及血清TNF-α、IL-10和NSE的影响［J］.现代中西医结合杂志,2018，27(5):541-544.
［11］　朱永林，李晓晓，杨伟琴.丁苯酞联合纤溶酶治疗急性脑梗死患者的临床疗效［J］.中华老年医学杂志,2018，38(1):45-48.
［12］　WANG S,MA F,HUANG L,et al.Dl-3-n-Butylphthalide (NBP):a promising therapeutic agent for ischemic stroke［J］.CNS Neurol Disord Drug Targets,2018,17(5):338-347.
［13］　李伟，陈颖，朱新岭，等.丁苯酞联合奥拉西坦治疗急性脑梗死后认知障碍的疗效观察［J］.中国药师，2018，21(7):1202-1204,1213.
［14］　CHEN N,ZHOU Z,LI Z,et al.3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke［J］.Drug Des Devel Ther,2018,12:4261-4271.

相似文献/References:

[1]孙治坤,马兴荣,陈　帅,等.丁苯酞对糖尿病合并阿尔茨海默病大鼠记忆能力的影响[J].新乡医学院学报,2021,38(2):112.[doi:10.7683/xxyxyxb.2021.02.003]
　SUN Zhikun,MA Xingrong,CHEN Shuai,et al.Effect of butylphthalide on the memory ability of rats with diabetes mellitus and Alzheimer′s disease[J].Journal of Xinxiang Medical University,2021,38(5):112.[doi:10.7683/xxyxyxb.2021.02.003]
[2]陈　娟.丁苯酞对急性脑梗死患者神经功能及血清S100B、同型半胱氨酸和血管生成素-1水平的影响[J].新乡医学院学报,2018,35(6):498.[doi:10.7683/xxyxyxb.2018.06.012]
　CHEN Juan.Effect of butylphthalide on the neurological function and the levels of serum S100B，homocysteine，angiopoietin-1 in patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2018,35(5):498.[doi:10.7683/xxyxyxb.2018.06.012]
[3]黄丽娟,张艳蕉,赵　亮,等.丁苯酞氯化钠注射液治疗中青年急性脑梗死疗效观察[J].新乡医学院学报,2017,34(7):586.[doi:10.7683/xxyxyxb.2017.07.008]
　HUANG Li-juan,ZHANG Yan-jiao,ZHAO Liang,et al.Efficacy of butylphthalide and sodium chloride injection in the treatment of young and middle aged patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2017,34(5):586.[doi:10.7683/xxyxyxb.2017.07.008]
[4]张　赟,郭艳平,张向东.丁苯酞静脉注射序贯口服治疗血管性认知障碍伴高同型半胱氨酸血症疗效观察[J].新乡医学院学报,2022,39(6):552.[doi:10.7683/xxyxyxb.2022.06.011]
　ZHANG Yun,GUO Yanping,ZHANG Xiangdong.Efficacy of butylphthalide intravenously and sequentially oral in the treatment of vascular cognitive impairment with hyperhomocysteinemia[J].Journal of Xinxiang Medical University,2022,39(5):552.[doi:10.7683/xxyxyxb.2022.06.011]
[5]易慧芳,白伟利.丁苯酞治疗颈内动脉系统脑分水岭梗死疗效观察[J].新乡医学院学报,2022,39(10):968.[doi:10.7683/xxyxyxb.2022.10.013]
　YI Huifang,BAI Weili.Effect of butylphthalide on cerebral watershed infarction of internal carotid artery system[J].Journal of Xinxiang Medical University,2022,39(5):968.[doi:10.7683/xxyxyxb.2022.10.013]

更新日期/Last Update: 2020-05-05