[1]郝利霞.拉贝洛尔联合短效硝苯地平治疗早发型子痫前期疗效观察[J].新乡医学院学报,2020,37(5):444-447.[doi:10.7683/xxyxyxb.2020.05.011]
　HAO Lixia.Effect of labetalol combined with short-acting nifedipine in the treatment of early-onset pre-eclampsia[J].Journal of Xinxiang Medical University,2020,37(5):444-447.[doi:10.7683/xxyxyxb.2020.05.011]
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拉贝洛尔联合短效硝苯地平治疗早发型子痫前期疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年5
页码:
444-447
栏目:
临床研究
出版日期:
2020-05-05

文章信息/Info

Title:
Effect of labetalol combined with short-acting nifedipine in the treatment of early-onset pre-eclampsia
作者:
郝利霞
（新乡市妇幼保健院产三科，河南　新乡　453003）
Author(s):
HAO Lixia
(Department of Obstetrics,Xinxiang Maternal and Child Health Hospital,Xinxiang 453003,Henan Province,China)
关键词:
早发型子痫前期; 拉贝洛尔; 硝苯地平; 血压
Keywords:
early-onset pre-eclampsia; labetalol; nifedipine; blood pressure
分类号:
R714.24+5
DOI:
10.7683/xxyxyxb.2020.05.011
文献标志码:
A
摘要:
目的　探讨拉贝洛尔联合短效硝苯地平治疗早发型子痫前期的临床效果。方法　选择2015年1月至2018年12月于新乡市妇幼保健院治疗并分娩的100例早发型子痫前期患者为研究对象，根据治疗方法将患者分为观察组和对照组，每组50例。2组患者入院后均给予饮食营养摄入控制、间断吸氧、血压监控、镇静、卧床休息等常规干预措施，在常规干预措施基础上，对照组患者给予拉贝洛尔治疗，观察组患者给予拉贝洛尔和短效硝苯地平联合治疗。对2组患者治疗前后收缩压（SBP）、舒张压（DBP）及血清白血病抑制因子（LIF）和Apelin水平进行比较，治疗7 d后评估2组患者临床疗效，并观察2组围生期母婴不良预后发生情况。结果　观察组和对照组患者治疗总有效率分别为98.0%（49/50）、82.0%（41/50），观察组患者治疗总有效率高于对照组（χ2=7.426，P＜0.05）。2组患者治疗前日间和夜间SBP、DBP比较差异均无统计学意义（P>0.05），2组患者治疗后日间和夜间SBP、DBP均低于治疗前（P＜0.05）；治疗后，观察组患者日间和夜间SBP、DBP均低于对照组（P＜0.05）。2组患者治疗前血清LIF、Apelin水平比较差异均无统计学意义（P>0.05）；2组患者治疗后血清LIF水平高于治疗前，Apelin水平低于治疗前（P＜0.05）；治疗后，观察组患者血清LIF水平高于对照组，Apelin水平低于对照组（P＜0.05）。观察组和对照组围生期母婴不良预后发生率分别为4.0%（2/50）、18.0%（9/50），观察组围生期母婴不良预后发生率低于对照组（χ2=5.602，P＜0.05）。结论　拉贝洛尔联合短效硝苯地平可以有效降低早发型子痫前期患者血压，改善母婴预后。
Abstract:
Objective　To investigate the clinical effect of labetalol combined with short-acting nifedipine in the treatment of early-onset pre-eclampsia.Methods　A total of 100 patients with early onset pre-eclampsia who delivered in Xinxiang Maternal and Child Health Hospital from January 2015 to December 2018 were selected as the study objects,and the patients were divided into observation group and control group according to the treatment method,with 50 cases in each group.After admission,the patients in both groups were given routine intervention measures such as diet control,intermittent oxygen inhalation,blood pressure monitoring,sedation,bed rest and so on.On the basis of routine interventions,the patients in the control group were treated with labetalol,while the patients in the observation group were treated with labetalol and short-acting nifedipine.The systolic blood pressure (SBP),diastolic blood pressure (DBP),serum leukaemia inhibitory factor (LIF) and Apelin levels were compared between the two groups before and after treatment.The clinical effect of the patients in the two groups was evaluated at seven days after treatment.The incidence of adverse maternal and neonatal outcomes in the two groups was observed.Results　The total effective rate in the observation group and the control group was 98.0%(49/50) and 82.0% (41/50),respectively.The total effective rate in the observation group was higher than that in the control group (χ2　=7.426,P＜0.05）。There was no significant difference in SBP and DBP during daytime and nighttime between the two groups before and after treatment (P>0.05).The SBP and DBP during daytime and nighttime after treatment were lower than those before treatment in the two groups (P＜0.05).There was no significant difference in the levels of serum LIF and Apelin between the two groups before treatment (P>0.05).The serum LIF level after treatment was higher than that before treatment,and the serum Apelin level after treatment was lower than that before treatment in the two groups (P＜0.05).After treatment,the serum LIF level in the observation group was higher than that in the control group,and the serum Apelin level in the observation group was lower than that in the control group (P＜0.05).The incidence of adverse maternal and neonatal outcomes in the observation group and the control group was 4.0% (2/50) and 18.0% (9/50),respectively.The incidence of adverse maternal and neonatal outcomes in the observation group was lower than that in the control group (χ2　=5.602,P＜0.05).Conclusion　Labetalol combined with short-acting nifedipine can effectively reduce blood pressure in patients with early-onset pre-eclampsia and improve maternal and infant prognosis.

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更新日期/Last Update: 2020-05-05