[1]高丽云,李 娜,连贺强,等.表观遗传学在先天性唇腭裂发生中的作用机制研究进展[J].新乡医学院学报,2020,37(1):008-11.[doi:10.7683/xxyxyxb.2020.01.003]
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表观遗传学在先天性唇腭裂发生中的作用机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年1
页码:
008-11
栏目:
专题报告
出版日期:
2020-01-05

文章信息/Info

作者:
高丽云1李 娜2连贺强1杨彩玲3秦海霞4张 丽1吴卫东1曹 佳1
(1.新乡医学院公共卫生学院毒理学教研室,河南 新乡 453003;2.卢氏县疾病预防控制中心预防科,河南 卢氏 472200;3.新乡医学院第一附属医院口腔颌面外科, 河南 卫辉 453100;4.新乡医学院第一附属医院妇科一病区,
河南 卫辉 453100)
关键词:
唇腭裂DNA甲基化非编码RNA组蛋白修饰X染色体失活
分类号:
R782.2
DOI:
10.7683/xxyxyxb.2020.01.003
文献标志码:
A
摘要:
先天性唇腭裂是一种常见的在胚胎发育过程中由各种因素引起的颌腭部组织发育不全或发育受阻而导致的出生缺陷,其主要影响因素有遗传和环境因素。目前,表观遗传学在很多领域有广泛深入的研究,但其在先天性唇腭裂中的研究报道较少。为了更好地研究先天性唇腭裂的发病情况,本文主要从DNA 甲基化、非编码 RNA、组蛋白修饰和X染色体失活等方面综述表观遗传学在先天性唇腭裂中的作用机制,为预防和治疗先天性唇腭裂提供理论依据。

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更新日期/Last Update: 2020-01-05