[1]袁容娣,周元国.配对免疫球蛋白样受体B在视神经损伤与修复中的作用研究进展[J].新乡医学院学报,2019,36(11):1088-1091.[doi:10.7683/xxyxyxb.2019.11.020]
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配对免疫球蛋白样受体B在视神经损伤与修复中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年11
页码:
1088-1091
栏目:
综述
出版日期:
2019-11-05

文章信息/Info

作者:
袁容娣12周元国1
(1.中国人民解放军陆军军医大学第三附属医院野战外科研究所,重庆 400042;2.中国人民解放军陆军军医大学第二附属医院眼科,重庆 400037)
关键词:
中枢神经系统视神经损伤再生配对免疫球蛋白样受体B
分类号:
R77
DOI:
10.7683/xxyxyxb.2019.11.020
文献标志码:
A
摘要:
中枢神经系统(CNS)损伤后再生十分困难,其修复与再生一直是医学研究的难点和热点。视神经是特殊的CNS,关于视神经损伤修复的研究,不仅对视相关疾病意义重大,也对CNS相关疾病有很好的借鉴意义。髓磷脂相关抑制因子(MAI)对CNS再生的抑制是视神经损伤后再生困难的关键因素之一。配对免疫球蛋白样受体B (PirB)是3种主要的MAI的共同受体,许多研究发现,PirB在包括视神经在内的CNS中广泛表达,并具有调控神经元发育、生长导向及可塑性等作用,阻抑CNS中PirB表达可以促进中枢神经再生修复。深入了解 PirB的功能可能为神经再生带来新的希望。

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更新日期/Last Update: 2019-11-05