[1]李怡春,张　敏,杨晓煜,等.CD133在人结直肠癌组织中的表达及其与缺氧诱导因子1α和核心蛋白聚糖的相关性[J].新乡医学院学报,2019,36(11):1036-1039.[doi:10.7683/xxyxyxb.2019.11.007]
　LI Yi-chun,ZHANG Min,YANG Xiao-yu,et al.Expression of CD133 in human colorectal cancer tissues and correlation with hypoxia-induced factor-1α and decorin[J].Journal of Xinxiang Medical University,2019,36(11):1036-1039.[doi:10.7683/xxyxyxb.2019.11.007]
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CD133在人结直肠癌组织中的表达及其与缺氧诱导因子1α和核心蛋白聚糖的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年11
页码:
1036-1039
栏目:
临床研究
出版日期:
2019-11-05

文章信息/Info

Title:
Expression of CD133 in human colorectal cancer tissues and correlation with hypoxia-induced factor-1α and decorin
作者:
李怡春; 张　敏; 杨晓煜; 侯玉龙; 姬颖华; 路　平
（新乡医学院第一附属医院肿瘤科，河南　卫辉　453100）
Author(s):
LI Yi-chun; ZHANG Min; YANG Xiao-yu; HOU Yu-long; JI Ying-hua; LU Ping
(Department of Oncology，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province，China)
关键词:
结直肠癌; CD133; 缺氧诱导因子1α; 核心蛋白聚糖; TNM分期
Keywords:
colorectal cancer; CD133; hypoxia-induced factor-1α; decorin; TNM stage
分类号:
R735.3+5
DOI:
10.7683/xxyxyxb.2019.11.007
文献标志码:
A
摘要:
目的　探讨人结直肠癌组织中CD133、缺氧诱导因子1α（HIF-1α）、核心蛋白聚糖（DCN）的表达，分析CD133表达与结直肠癌临床病理特征及HIF-1α、DCN的相关性。方法　收集 2012年 12月至 2013年 7月新乡医学院第一附属医院保存的结直肠癌组织及其相对应的癌旁组织标本各34例。应用免疫组织化学法检测癌组织及癌旁组织中CD133、HIF-1α及DCN的表达，分析CD133与HIF-1α及DCN表达的相关性，以及CD133表达与结直肠癌患者临床病理特征的关系。结果　结直肠癌组织中CD133、HIF-1α、DCN的相对表达量分别为0.123±0.023、0.117±0.036、0.049±0.018，癌旁组织中CD133、HIF-1α、DCN的相对表达量分别为0.26±0.048、0.018±0.035、0.211±0.014；结直肠癌组织中CD133、HIF-1α的相对表达量高于癌旁组织（P<0.05），结直肠癌组织中DCN的相对表达量低于癌旁组织（P<0.05）。CD133表达与淋巴结转移、TNM分期、病理分级有关（P<0.05），与患者年龄、性别无关（P>0.05）。Pearson相关分析显示，结直肠癌组织中CD133表达与HIF-1 a表达呈正相关（P<0.05）,与DCN表达无显著相关性（P>0.05）。结论　结直肠癌组织中CD133与HIF-1α表达呈正相关；CD133可以作为判断结直肠癌恶性程度的指标，也可作为判断患者预后的潜在指标。
Abstract:
Objective　To investigate the expression of CD133，hypoxia-inducible factor-1α (HIF-1α) and decorin (DCN) in human colorectal cancer tissues，and to analyze the correlation between the expression of CD133 and the clinicopathological features of colorectal cancer,HIF-1α and DCN.Methods　The cancerous tissues and the corresponding paracancer tissues of 34 patients with colorectal cancer were selected in the First Affiliated Hospital of Xinxiang Medical University from December 2012 to July 2013.The expressions of CD133，HIF-1α and DCN were determined by immunohistochemical method.The correlation between CD133 and HIF-1 α，DCN was analyzed,and the relationship between the expression of CD133 and clinicopathological characteristics of colorectal cancer was analyzed.Results　The relative expression of the CD133，HIF-1α and DCN in cancerous tissue was 0.123±0.023,0.117±0.036，0.049±0.018,respectively.The relative expression of the CD133，HIF-1α and DCN in paracancer tissue was 0.26±0.048、0.018±0.035、0.211±0.014 respectively.The relative expression of the CD133 and HIF-1α in the cancerous tissue was higher than that in the paracancer tissue(P<0.05).The expression of the DCN in the cancerous tissue was lower than that in the paracancer tissue （P<0.05）.The expression of CD133 was correlated with lymph node metastasis，TNM stage and pathological grade (P<0.05)，but it was not correlated with the age and gender of patients(P<0.05).Pearson correlation analysis showed that the expression of CD133 in colorectal cancer tissues was positively correlated with the expression of HIF-1α (P<0.05)，but it was not significantly possitive correlated with DCN (P>0.05).Conclusion　There is a significant possitive correlation between CD133 and HIF-1α in colorectal cancer patients.CD133 can be used as an indicator of colorectal cancer malignancy and a potential indicator of prognosis.

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更新日期/Last Update: 2019-11-05