[1]刘 爽,宋 丹,左秀玲.糖维胶囊对2型糖尿病并发微血管病变患者血糖和血脂水平及血管内皮功能的影响[J].新乡医学院学报,2019,36(10):979-982.[doi:10.7683/xxyxyxb.2019.10.018]
 LIU Shuang,SONG Dan,ZUO Xiu-ling.Effect of Tangwei capsule on blood glucose and blood lipid levels and vascular endothelial function in patients with type 2 diabetes mellitus complicated with microangiopathy[J].Journal of Xinxiang Medical University,2019,36(10):979-982.[doi:10.7683/xxyxyxb.2019.10.018]
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糖维胶囊对2型糖尿病并发微血管病变患者血糖和血脂水平及血管内皮功能的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年10
页码:
979-982
栏目:
临床研究
出版日期:
2019-10-05

文章信息/Info

Title:
Effect of Tangwei capsule on blood glucose and blood lipid levels and vascular endothelial function in patients with type 2 diabetes mellitus complicated with microangiopathy
作者:
刘 爽宋 丹左秀玲
(郑州市第一人民医院内分泌科,河南 郑州 450000)
Author(s):
LIU ShuangSONG DanZUO Xiu-ling
(Department of Endocrinology,the First People′s Hospital of Zhengzhou City,Zhengzhou 450000,Henan Province,China)
关键词:
2型糖尿病微血管病变糖维胶囊血脂血糖血管内皮功能
Keywords:
type 2 diabetes mellitusmicroangiopathyTangwei capsuleblood lipidblood glucosevascular endothelial function
分类号:
R587.1
DOI:
10.7683/xxyxyxb.2019.10.018
文献标志码:
A
摘要:
目的 探讨糖维胶囊对2型糖尿病(T2DM)并发微血管病变患者血糖和血脂水平及血管内皮功能的影响。方法 选择2016年6月至2018年3月郑州市第一人民医院收治的168例T2DM并发微血管病变患者为研究对象,根据治疗方法将患者分为观察组和对照组,每组84例。对照组患者给予门冬胰岛素治疗,观察组患者在对照组治疗基础上给予糖维胶囊治疗。分别于治疗前和治疗后检测2组患者血糖和血脂水平,并使用彩色多普勒超声检查患者血管内皮功能。结果 治疗前2组患者空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)水平及胰岛素抵抗指数(HOMA-IR)比较差异均无统计学意义(P>0.05);2组患者治疗后FBG、HbA1c水平及HOMA-IR显著低于治疗前,FINS水平显著高于治疗前(P<0.05);治疗后,观察组患者FBG水平及HOMA-IR显著低于对照组,HbA1c和FINS水平显著高于对照组(P<0.05)。治疗前2组患者血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平比较差异无统计学意义(P>0.05);2组患者治疗后血清TG、TC、LDL-C水平显著低于治疗前,HDL-C水平显著高于治疗前(P<0.05)。治疗后,观察组患者血清TG、TC及HDL-C水平显著高于对照组,LDL-C水平显著低于对照组(P<0.05)。治疗前2组患者肱动脉基础血管内径、反应性充血血管内径及含服硝酸甘油后血管内径比较差异均无统计学意义(P>0.05),2组患者治疗后肱动脉基础血管内径、反应性充血血管内径及含服硝酸甘油后血管内径大于治疗前(P<0.05);治疗后,观察组患者肱动脉基础血管内径、反应性充血血管内径及含服硝酸甘油后血管内径大于对照组(P<0.05)。结论 糖维胶囊可以改善T2DM并发微血管病变患者的血糖和血脂水平,提高患者血管内皮功能。
Abstract:
Objective To investigate the effect of Tangwei capsule on blood glucose and blood lipid levels and vascular endothelial function in patients with type 2 diabetes mellitus(T2DM) complicated with microangiopathy.Methods A total of 168 patients with T2DM complicated with microangiopathy admitted to the First People′s Hospital Zhengzhou City from June 2016 to March 2018 were selected as the subjects,and the patients were divided into observation group and control group according to the treatment methods,with 84 cases in each group.The patients in the control group were treated with insulin aspart,while the patients in the observation group were treated with Tangwei capsule on the basis of the treatment in the control group.The blood glucose and blood lipid levels were measured and the vascular endothelial function was examined by color Doppler ultrasound before and after treatment.Results There were no significant difference in the levels of fasting blood glucose (FBG),glycosylated hemoglobin (HbA1c),fasting insulin (FINS) and insulin resistance index (HOMA-IR) between the two groups before treatment (P>0.05).Compared with before treatment,the levels of FBG,HbA1c and HOMA-IR were significantly lower and the level of FINS was significantly higher after treatment in the two groups (P<0.05).After treatment,the levels of FBG and HOMA-IR in the observation group were significantly lower than those in the control group,and the levels of HbA1c and FINS in the observation group were significantly higher than those in the control group (P<0.05).There was no significant difference in the levels of serum total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) between the two groups before treatment (P>0.05).Compared with before treatment,the levels of serum TG,TC and LDL-C decreased significantly and the level of serum HDL-C increased significantly after treatment in the two groups (P<0.05).After treatment,the levels of serum TG,TC and HDL-C in the observation group were significantly higher than those in the control group,and the level of serum LDL-C in the observation group was significantly lower than that in the control group (P<0.05).There was no significant difference in the internal diameter of brachial artery at baseline,reactive hyperemia and after nitroglycerin administration between the two groups before treatment (P>0.05).The internal diameter of brachial artery at baseline,reactive hyperemia and after nitroglycerin administration after treatment was greater than that before treatment(P<0.05).The internal diameter of brachial artery at baseline,reactive hyperemia and after nitroglycerin administration after treatment in the observation group was greater than that in the control group(P<0.05).Conclusion Tangwei capsule can improve blood sugar and blood lipid levels and vascular endothelial function in patients with T2DM complicated with microangiopathy.

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更新日期/Last Update: 2019-10-05