[1]鲁世金,孙长英.免疫衰老对骨代谢及骨源性激素分泌的影响研究进展[J].新乡医学院学报,2019,36(9):896-900.[doi:10.7683/xxyxyxb.2019.09.022]
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免疫衰老对骨代谢及骨源性激素分泌的影响研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年9
页码:
896-900
栏目:
综述
出版日期:
2019-09-05

文章信息/Info

作者:
鲁世金1孙长英2
(1.广西中医药大学附属瑞康医院转化医学中心,广西 南宁 530011;2.长治医学院附属和平医院骨科,山西 长治 046000)
关键词:
免疫衰老促炎细胞因子免疫细胞骨代谢骨源性激素
分类号:
R392.12
DOI:
10.7683/xxyxyxb.2019.09.022
文献标志码:
A
摘要:
机体免疫系统功能随年龄增长逐渐下降,产生炎性微环境,不仅影响骨骼本身的代谢,还通过影响骨源性激素的分泌而间接影响全身多组织器官的功能,增加多种衰老相关疾病如2型糖尿病、阿尔茨海默病、心血管疾病、衰弱、肌肉减少症、骨质疏松症和癌症等的发生风险。研究发现,免疫衰老引发成骨细胞、破骨细胞、造血干细胞等骨代谢相关细胞功能改变的同时,也诱发了炎性细胞因子、T和B淋巴细胞、树突状细胞、自然杀伤细胞等的生成和功能改变,因此,研究免疫衰老对骨代谢及骨源性激素的影响可能为衰老相关疾病的研究提供理论基础和研究靶点。本文就免疫衰老对骨代谢及骨源性激素分泌影响的相关研究进行综述。

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更新日期/Last Update: 2019-09-05