[1]王荣荣,张子璐,李嘉欣,等.酒精所致氧化应激相关研究进展[J].新乡医学院学报,2019,36(9):891-895.[doi:10.7683/xxyxyxb.2019.09.021]
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酒精所致氧化应激相关研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年9
页码:
891-895
栏目:
综述
出版日期:
2019-09-05

文章信息/Info

作者:
王荣荣1张子璐1李嘉欣1张锋1郭嘉伟1张瑞岭2
(1.新乡医学院第二临床学院,河南 新乡 453003;2.新乡医学院第二附属医院,河南 新乡 453002)
关键词:
酒精氧化应激活性氧抗氧化炎症
分类号:
R749.62
DOI:
10.7683/xxyxyxb.2019.09.021
文献标志码:
A
摘要:
国内外研究表明,与酒精相关的疾病是由过量的酒精饮用及酒精与其他因素共同作用引起的。酒精代谢及毒性可影响机体氧化应激水平,长期饮酒或过度饮酒会导致严重的系统性衰弱疾病,包括肝纤维化、中枢神经系统损伤、胃溃疡、酒精性肺病和发育障碍等。酒精激活氧化应激并最终导致疾病发生的分子机制目前尚无定论,可能与线粒体电子传递链和内质网应激有关。在这些相关疾病的治疗研究中发现,酒精可以引起包括中枢神经系统在内的多组织、多器官的氧化应激异常,而具有抗氧化作用的药物对这些疾病表现出了良好的疗效。本文就酒精所致肝损伤、中枢神经系统受损、胃肠疾病、肺脏病变及血液学病变与氧化应激的关系进行综述。

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更新日期/Last Update: 2019-09-05