[1]王光亮,吴雪梅.缝隙连接蛋白及其阻断剂研究进展[J].新乡医学院学报,2019,36(8):792-796.[doi:10.7683/xxyxyxb.2019.08.022]
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缝隙连接蛋白及其阻断剂研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年8
页码:
792-796
栏目:
综述
出版日期:
2019-08-05

文章信息/Info

作者:
王光亮1; 吴雪梅2
(1.东北国际医院第一医院心内科，辽宁　沈阳　110000；2.吉林大学第一医院小儿神经科，吉林　长春　130000)
关键词:
缝隙连接; 缝隙连接蛋白Cx43; 缝隙连接蛋白Cx36; 缝隙连接蛋白阻断剂
DOI:
10.7683/xxyxyxb.2019.08.022
文献标志码:
A
摘要:
缝隙连接是细胞间的主要连接方式，广泛分布于心肌细胞及神经细胞等。细胞间电活动的传递主要是通过缝隙连接来完成，丰富的、通道阻抗小的缝隙连接构成了细胞间电偶联的基础。缝隙连接蛋白Cx43是构成心室缝隙连接通道的结构基础，与心房颤动、风湿性心瓣膜病等心脏疾病密切相关。缝隙连接蛋白Cx36介导的缝隙连接通路在癫痫、神经元损伤等神经系统疾病中扮演着重要角色。在中枢神经系统中，缝隙连接蛋白Cx36是唯一在神经元特异性表达的缝隙连接蛋白，尤其在海马的CA1、CA3、CA4等区高度表达，Cx36可能在癫痫电活动方面发挥重要作用。缝隙连接蛋白介导通道的通透功能具有较高的可塑性，可以被很多因素调控。应用缝隙连接阻断剂可减轻缝隙连接相关疾病的症状，在心脏、神经系统疾病新药研发中具有重要作用。因此，缝隙连接阻断剂有可能成为相关疾病治疗的研究热点。本文就心肌细胞及神经细胞缝隙连接蛋白的典型代表Cx43、Cx36及其阻断剂的研究进展进行综述。

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更新日期/Last Update: 2019-08-05