[1]孔令宇,吴　畏,杨亚勤,等.法舒地尔对急性心肌梗死患者血清心肌酶及细胞因子水平的影响[J].新乡医学院学报,2019,36(8):781-784.[doi:10.7683/xxyxyxb.2019.08.019]
　KONG Ling-yu,WU Wei,YANG Ya-qin,et al.Effect of fasudil on the serum levels of myocardial enzymes and cytokines in patients with acute myocardial infarction[J].Journal of Xinxiang Medical University,2019,36(8):781-784.[doi:10.7683/xxyxyxb.2019.08.019]
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法舒地尔对急性心肌梗死患者血清心肌酶及细胞因子水平的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年8
页码:
781-784
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Effect of fasudil on the serum levels of myocardial enzymes and cytokines in patients with acute myocardial infarction
作者:
孔令宇1; 吴　畏1; 杨亚勤1; 马文婷2; 石金河1
（1.新乡医学院第一附属医院急诊科，河南　卫辉　453100；2.新乡医学院三全学院诊断学实验室，河南　新乡　453003）
Author(s):
KONG Ling-yu1; WU Wei1; YANG Ya-qin1; MA Wen-ting2; SHI Jin-he1
(1.Department of Emergency,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100，Henan Province,China;2.Department of Diagnostic Laboratory of Sanquan College,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
急性心肌梗死; 法舒地尔; 阿司匹林; 心肌保护
Keywords:
acute myocardial infarction; fasudil; aspirin; myocardial protection
分类号:
R542.2+2
DOI:
10.7683/xxyxyxb.2019.08.019
文献标志码:
A
摘要:
目的　观察法舒地尔对急性心肌梗死患者血清心肌酶及细胞因子的影响。方法　选择新乡医学院第一附属医院于2014年6月至2018年6月收治的104例急性心肌梗死患者为研究对象，根据治疗方法将患者分为对照组和观察组，每组52例。2组患者均给予常规溶栓治疗，在此基础上，对照组患者给予阿司匹林，口服，首次剂量为300 mg，第2天减为100 mg直至治疗结束，每日1次，连续治疗2周；在对照组治疗基础上，观察组患者给予法舒地尔30 mg，静脉滴注，每日2次，连续治疗2周。2组患者治疗前后采用Griess法检测血清一氧化氮（NO）水平，酶联免疫吸附试验检测血清C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）水平，速率法检测血清肌酸激酶（CK）与乳酸脱氢酶（LDH）水平。结果　治疗前2组患者血清CRP、TNF-α、IL-1β、IL-6及NO水平比较差异均无统计学意义（P>0.05）;治疗后2组患者血清CRP、TNF-α、IL-1β、IL-6水平均显著低于治疗前，NO水平显著高于治疗前（P<0.05）；治疗后，观察组患者血清CRP、TNF-α、IL-1β、IL-6水平显著低于对照组，NO水平显著高于对照组（P<0.05）。治疗前2组患者血清CK、LDH水平比较差异均无统计学意义（P>0.05）;治疗后2组患者血清CK、LDH水平均显著低于治疗前（P<0.05）；治疗后，观察组患者血清CK、LDH水平显著低于对照组（P<0.05）。结论　法舒地尔可显著降低急性心肌梗死患者血清心肌酶水平，提高血清NO的水平，减轻促炎因子的释放，减少促炎因子对心肌的损伤。
Abstract:
Objective　To observe the effect of fasudil on the serum levels of myocardial enzymes and cytokines in patients with acute myocardial infarction(AMI).Methods　One hundred and four patients with AMI admitted to the First Affiliated Hospital of Xinxiang Medical University from June 2014 to June 2018 were selected and divided into control group and observation group according to the treatment method，with 52 patients in each group.All patients were given routine thrombolytic therapy.Based on this,the patients in the control group were given aspirin orally(the first dose was 300 mg,the dose was reduced to 100 mg from the second day until the end of the treatment),once a day for two weeks.On the basis of the control group,the patients in the observation group were given fasudil 30 mg,intravenous drip,twice a day for two weeks.The levels of serum nitric oxide (NO) were measured by Griess method;the levels of serum C-reactive protein (CRP),tumor necrosis factor-alpha (TNF-α),interleukin- 1β(IL-1β) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay and the levels of serum creatine kinase (CK) and lactate dehydrogenase (LDH) were measured by rate method in two groups before and after treatment.Results　There was no significant difference in the serum levels of CRP,TNF-α,IL-1β,IL-6 and NO between the two groups before treatment (P>0.05).The serum levels of CRP,TNF-α,IL-1β and IL-6 after treatment were significantly lower than those before treatment in the two groups(P<0.05),but the level of NO was significantly higher than that before treatment (P<0.05).After treatment,the serum levels of CRP,TNF-α,IL-1β and IL-6 of patients in the observation group were significantly higher than those in the control group (P<0.05).There was no significant difference in the levels of serum CK and LDH of patients between the two groups before treatment (P>0.05)；the serum levels of CK and LDH of patients after treatment were significantly lower than those before treatment in the two groups (P<0.05).After treatment,the serum levels of CK and LDH of patients in the observation group were significantly lower than those in the control group (P<0.05).Conclusion　Fasudil can significantly reduce the levels of serum myocardial enzymes,increase the level of serum NO,decrease the release of proinflammatory factors,and lessen the myocardial damage caused by proinflammatory factors in patients with AMI.

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更新日期/Last Update: 2019-08-05