[1]刘　佟,杨留勤,武莉萍,等.Rab-3D在结直肠腺癌组织中的表达及临床意义[J].新乡医学院学报,2019,36(8):773-776.[doi:10.7683/xxyxyxb.2019.08.017]
　LIU Tong,YANG Liu-qin,WU Li-ping,et al.Expression and clinical significance of Rab-3D in colorectal adenocarcinoma[J].Journal of Xinxiang Medical University,2019,36(8):773-776.[doi:10.7683/xxyxyxb.2019.08.017]
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Rab-3D在结直肠腺癌组织中的表达及临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年8
页码:
773-776
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Expression and clinical significance of Rab-3D in colorectal adenocarcinoma
作者:
刘　佟; 杨留勤; 武莉萍; 高国伟; 吴冬梅; 仁民柱; 袁东方; 董国艳
（新乡医学院第四临床学院放疗科，河南　新乡　453000）
Author(s):
LIU Tong; YANG Liu-qin; WU Li-ping; GAO Guo-wei; WU Dong-mei; REN Min-zhu; YUAN Dong-fang; DONG Guo-yan
(Department of Radiotherapy,the Fourth Clinical College of Xinxiang Medical University,Xinxiang 453000,Henan Province,China)
关键词:
结直肠腺癌; Rab-3D; 免疫组织化学
Keywords:
colorectal adenocarcinoma; Rab-3D; immunohistochemistry
分类号:
R735.3
DOI:
10.7683/xxyxyxb.2019.08.017
文献标志码:
A
摘要:
目的　探讨Rab-3D在结直肠腺癌组织中的表达及临床意义。方法　选取2017年10月至2018年5月于新乡市中心医院行结直肠腺癌切除术患者的癌组织（n=74）及其部分配对的癌旁组织(n=40)和正常组织(n=40)标本，采用免疫组织化学法检测各组织中Rab-3D表达情况，并分析Rab-3D表达与患者临床特征的关系。结果　结直肠腺癌组织、癌旁组织和正常组织中Rab-3D高表达率分别为81.08％（60/74）、12.50％（5/40）和5.00％（2/40）；结直肠腺癌组织中Rab-3D高表达率显著高于癌旁组织及正常组织（χ2=49.381、60.584，P<0.05）；癌旁组织与正常组织中Rab-3D高表达率比较差异无统计学意义（χ2=0.626，P>0.05）。Rab-3D在结直肠腺癌组织中的表达与患者性别、年龄、肿瘤部位、肿瘤组织分化、肿瘤大小无关（P>0.05）,与肿瘤浸润深度、淋巴结转移和TNM分期有关（P<0.05）。结直肠腺癌组织中Rab-3D表达与患者血清癌胚抗原水平有关（χ2=7.400，P<0.05），与血清糖类抗原标志物(CA)199、CA242、CA153水平无关（χ2=1.228、2.814、0.010，P<0.05)。结论　Rab-3D在结直肠腺癌组织中呈高表达，且与结直肠腺癌的高侵袭、高转移能力密切相关。
Abstract:
Objective　To explore the expression of Rab-3D in colorectal adenocarcinoma and its clinical significance.Methods　The specimens of colorectal adenocarcinoma tissue(n=74) and partially matched paracancerous tissues(n=40) and normal tissues(n=40) of patients with colorectal adenocarcinoma in Xinxiang Central Hospital from October 2017 to May 2018 were selected.The expression of Rab-3d in each tissue was detected by immunohistochemistry,and the relationship between the expression of Rab-3d and the clinical characteristic of patients was analysed.Results　The high expression rate of Rab-3D in colorectal adenocarcinoma tissues,paracancerous tissues and normal tissues were 81.08％（60/74），12.50％（5/40）and 5.00％（2/40） respectively;the high expression rate of Rab-3D in colorectal adenocarcinoma tissues was significantly higher than that in paracancerous tissues and normal tissues (χ2=49.381，60.584；P<0.05);there was no significant difference in the high expression rate of Rab-3D between adjacent tissues and normal tissues (χ2=0.626，P>0.05).The expression of Rab-3D in colorectal adenocarcinoma tissues was not related to the gender,age,tumor location,tumor differentiation and tumor size (P>0.05),but was related to the depth of invasion,lymph node metastasis and TNM stage (P<0.05).The expression of Rab-3D in colorectal adenocarcinoma tissues was correlated with the serum level of carcinoembryonic antigen (χ2=7.400，P<0.05),but not correlated with serum levels of carbohydrate antigen (CA)19-9,CA242 and CA153 (χ2=1.228,2.814,0.010;P<0.05).Conclusion　The expression of Rab-3D in colorectal adenocarcinoma is higher and it is closely relate to the high invasion and metastasis of colorectal adenocarcinoma.

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更新日期/Last Update: 2019-08-05