[1]杨西超,郑朝晖,牛 敏,等.痛风性关节炎患者血清白细胞介素-1β、肿瘤坏死因子-α和环氧化酶-2水平变化及临床意义[J].新乡医学院学报,2019,36(8):752-754.[doi:10.7683/xxyxyxb.2019.08.012]
 YANG Xi-chao,ZHENG Zhao-hui,NIU Min,et al.Changes and clinical significance of the levels of serum interleukin-1β,tumor necrosis factor-α and cyclooxygenase-2 in patients with gouty arthritis[J].Journal of Xinxiang Medical University,2019,36(8):752-754.[doi:10.7683/xxyxyxb.2019.08.012]
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痛风性关节炎患者血清白细胞介素-1β、肿瘤坏死因子-α和环氧化酶-2水平变化及临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年8
页码:
752-754
栏目:
临床研究
出版日期:
2019-08-05

文章信息/Info

Title:
Changes and clinical significance of the levels of serum interleukin-1β,tumor necrosis factor-α and cyclooxygenase-2 in patients with gouty arthritis
作者:
杨西超郑朝晖牛 敏吴振彪杜望磊
(中国人民解放军空军军医大学第一附属医院临床免疫科,陕西 西安 710032)
Author(s):
YANG Xi-chaoZHENG Zhao-huiNIU MinWU Zhen-biaoDU Wang-lei
(Department of Clinical Immunology,the First Affiliated Hospital of Air Force Medical University,Xi′an 710032,Shaanxi Province,China)
关键词:
痛风性关节炎白细胞介素-1β肿瘤坏死因子-α环氧化酶-2
Keywords:
gouty arthritisinterleukin-1βtumor necrosis factor-αcyclooxygenase-2
分类号:
R684.3
DOI:
10.7683/xxyxyxb.2019.08.012
文献标志码:
A
摘要:
目的 观察不同严重程度痛风性关节炎患者血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)及环氧化酶-2(COX-2)水平的变化及临床意义。方法 选择2015年6月至 2018年6月中国人民解放军空军军医大学第一附属医院收治的150例痛风性关节炎患者为研究对象,其中急性发作期患者100例,缓解期患者50例(Ⅰ组);100例急性发作期患者根据主诉疼痛程度评分法分为Ⅱ组(轻度患者50例)和Ⅲ组(中、重度患者50例);另选择同期体检健康者150例作为对照组。采用酶联免疫吸附试验检测4组受试者血清IL-1β、TNF-α和COX-2水平。结果 Ⅰ组与对照组受试者血清IL-1β、TNF-α及COX-2水平比较差异均无统计学意义(P>0.05)。急性期第1、3、7天,Ⅱ组患者血清IL-1β水平显著高于Ⅰ组(P<0.05);急性期第10、14天,Ⅱ组与Ⅰ组患者血清IL-1β水平比较差异无统计学意义(P>0.05)。急性期第1、3天,Ⅱ组患者血清TNF-α、COX-2水平显著高于Ⅰ组(P<0.05);急性期第7、10、14天,Ⅱ组与Ⅰ组患者血清TNF-α、COX-2水平比较差异无统计学意义(P>0.05)。急性期第1、3、7、10天,Ⅲ组患者血清IL-1β、TNF-α水平显著高于Ⅱ组(P<0.05);急性期第14天,Ⅲ组与Ⅱ组患者血清IL-1β、TNF-α水平比较差异无统计学意义(P>0.05)。急性期第1、3、7天,Ⅲ组患者血清COX-2水平显著高于Ⅱ组(P<0.05);急性期第10、14天,Ⅲ组与Ⅱ组患者血清COX-2水平比较差异无统计学意义(P>0.05)。结论 痛风性关节炎患者血清炎性因子水平升高,炎性因子可能参与了痛风性关节炎的发病机制,炎性因子水平检测有助于痛风性关节炎的早期诊断、病情及预后评估。
Abstract:
Objective To investigate the changes and clinical significance of the levels of serum interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α) and cyclooxygenase-2 (COX-2) in patients with gouty arthritis of different degrees.Methods A total of 150 patients with gouty arthritis admitted to the First Affiliated Hospital of Air Force Medical University from June 2015 to June 2018 were selected as the study subjects,including 100 patients in acute attack stage and 50 patients in remission stage (Group Ⅰ).The 100 patients in acute attack stage were divided into Group Ⅱ (50 patients with mild illness) and group Ⅲ (50 patients with moderate or severe illness) according to the verbal rating scale.In addition,150 healthy persons were selected as control group at the same time.The levels of serum IL-1β,TNF-α and COX-2 were measured by enzyme linked immunosorbent assay.Results There was no significant difference in the levels of serum IL-1β,TNF-α and COX-2 between groupⅠand the control group (P>0.05).On the 1st,3rd and 7th day of acute phase,the level of serum IL-1β in the group Ⅱ was significantly higher than that in the group Ⅰ (P<0.05).On the 10th and 14th day of acute phase,there was no significant difference in serum IL-1β level between the group Ⅱ and group Ⅰ (P>0.05).The levels of serum TNF-α and COX-2 in the group Ⅱ were significantly higher than those in the group Ⅰ on the 1st and 3rd day of acute phase (P<0.05).There was no significant difference in serum TNF-α and COX-2 levels between the group Ⅱ and group Ⅰ on the 7th,10th and 14th day of acute phase (P>0.05).The levels of serum IL-1β and TNF-α in the group Ⅲ were significantly higher than those in the group Ⅱ on the 1st,3rd,7th and 10th day of acute phase (P<0.05).There was no significant difference in levels of serum IL-1β and TNF-α between the group Ⅲ and group Ⅱ on the 14th day of acute phase (P>0.05).On the 1st,3rd and 7th day of acute phase,the serum COX-2 level in the group Ⅲ was significantly higher than that in the group Ⅱ (P<0.05);but there was no significant difference in serum COX-2 level between group Ⅲ and group Ⅱ on the 10th and 14th day of acute phase (P>0.05).Conclusion The levels of serum inflammatory factors in patients with gouty arthritis increased,the inflammatory factors may participate in the pathogenesis of gouty arthritis.The detection of inflammatory factors is helpful for the early diagnosis,condition and prognosis evaluation of gouty arthritis.

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更新日期/Last Update: 2019-08-05