[1]齐光照,李朵璐.细胞色素P450酶CYP2W1研究进展[J].新乡医学院学报,2019,36(7):698-700.[doi:10.7683/xxyxyxb.2019.07.025]
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细胞色素P450酶CYP2W1研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年7
页码:
698-700
栏目:
综述
出版日期:
2019-07-05

文章信息/Info

作者:
齐光照李朵璐
(郑州大学第一附属医院药学部,河南 郑州 450052)
关键词:
细胞色素P450酶2W1结直肠癌靶向药物基因多态性
分类号:
R456
DOI:
10.7683/xxyxyxb.2019.07.025
文献标志码:
A
摘要:
细胞色素P450酶2W1(CYP2W1)是肿瘤特异性代谢酶,在结直肠癌和肝癌等肿瘤组织中高表达,而在正常成人组织细胞中不表达。CYP2W1可以将非细胞毒性的倍癌霉素类化合物氧化代谢为具有细胞毒作用的代谢产物,进而杀死高表达CYP2W1的肿瘤细胞。本文将介绍CYP2W1的遗传多态性及其与结直肠癌发生风险的相关性、表达调控机制、底物特异性和作为肿瘤标志物和抗肿瘤药物靶点的潜力。

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更新日期/Last Update: 2019-07-05