[1]李春燕,韩听锋,岳　磊.巴曲酶对急性脑梗死患者神经功能及日常生活能力和血液流变学的影响[J].新乡医学院学报,2019,36(6):544-546.[doi:10.7683/xxyxyxb.2019.06.011]
　LI Chun-yan,HAN Ting-feng,YUE Lei.Effect of batroxobin on neurological function，ability of daily living and hemorheology in patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2019,36(6):544-546.[doi:10.7683/xxyxyxb.2019.06.011]
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巴曲酶对急性脑梗死患者神经功能及日常生活能力和血液流变学的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年6
页码:
544-546
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Effect of batroxobin on neurological function，ability of daily living and hemorheology in patients with acute cerebral infarction
作者:
李春燕1; 韩听锋2; 岳　磊1
（1.洛阳市中心医院急诊科，河南　洛阳　471000；2.洛阳市中心医院妇科，河南　洛阳　471000）
Author(s):
LI Chun-yan1; HAN Ting-feng2; YUE Lei1
（1.Department of Emergency，Luoyang Central Hospital，Luoyang 471000，Henan Province，China；2.Department of Gynaecology，Luoyang Central Hospital，Luoyang 471000，Henan Province，China）
关键词:
急性脑梗死; 巴曲酶; 神经功能; 日常生活能力; 血液流变学
Keywords:
acute cerebral infarction; batroxobin; neural function; ability of daily life; hemorheology
分类号:
R743.33
DOI:
10.7683/xxyxyxb.2019.06.011
文献标志码:
A
摘要:
目的　探讨巴曲酶对急性脑梗死（ACI）患者神经功能、日常生活能力及血液流变学的影响。方法　选择2017年1月至2018年3月洛阳市中心医院收治的80例ACI患者为研究对象，根据治疗方法分为观察组和对照组，每组40例。2组患者均给予控制血糖、调节血脂、降血压、脑神经营养支持等常规治疗，对照组患者在常规治疗基础上给予阿司匹林肠溶片和阿托伐他汀钙片治疗，观察组患者在对照组治疗基础上给予巴曲酶治疗。分别于治疗前、后采用血液黏附检测仪检测2组患者全血低切黏度、红细胞聚集指数、全血还原黏度、血小板聚集率及纤维蛋白原水平，应用美国国立卫生研究院卒中量表（NIHSS）和神经功能缺损程度量表（NFDS）对患者进行神经功能缺损评分，应用Barthel指数量表对患者的日常生活能力进行评估。结果　2组患者治疗前NIHSS、NFDS评分比较差异无统计学意义（P>0.05），2组患者治疗后NIHSS、NFDS评分显著低于治疗前（P<0.05）；治疗后，观察组患者NIHSS、NFDS评分显著低于对照组（P<0.05）。2组患者治疗前日常生活能力评分比较差异无统计学意义（P>0.05），2组患者治疗后日常生活能力评分显著高于治疗前（P<0.05）；治疗后，观察组患者日常生活能力评分显著高于对照组（P<0.05）。2组患者治疗前全血低切黏度、红细胞聚集指数、全血还原黏度、血小板聚集率、纤维蛋白原水平比较差异均无统计学意义（P>0.05），2组患者治疗后全血低切黏度、红细胞聚集指数、全血还原黏度、血小板聚集率、纤维蛋白原水平显著低于治疗前（P<0.05）；治疗后，观察组患者全血低切黏度、红细胞聚集指数、全血还原黏度、血小板聚集率、纤维蛋白原水平显著低于对照组（P<0.05）。结论　巴曲酶能够显著改善 ACI患者血液流变学和神经功能，提高患者日常生活能力。
Abstract:
Objective　To investigate the effect of batroxobin on neurological function，ability of daily living and hemorheology in patients with acute cerebral infarction（ACI）.Methods　A total of 80 patients with ACI admitted to Luoyang Central Hospital from January 2017 to March 2018 were selected as the research subjects.The patients were divided into observation group and control group according to the treatment method，40 cases in each group.All patients were given routine treatment，such as controlling blood sugar，regulating blood lipid，lowering blood pressure and brain neurotrophic support.The patients in the control group were treated with aspirin enteric-coated tablets and atorvastatin calcium tablets on the basis of routine treatment，while the patients in the observation group were treated with batroxobin on the basis of the treatment of patients in the control group.The whole blood low shear viscosity，erythrocyte aggregation index，whole blood reduced viscosity，platelet aggregation rate and fibrinogen level were measured by blood adhesion tester；the neurological impairment was evaluated by the National Institutes of Health Stroke Scale （NIHSS） and neurological deficiency degree scale （NFDS），and the ability of daily living of patients was evaluated by Barthel index before and after treatment.Results　There was no significant difference in NIHSS and NFDS scores between the two groups before treatment （P>0.05）.The NIHSS and NFDS scores of patients after treatment were significantly lower than those before treatment in the two groups（P<0.05）.The NIHSS and NFDS scores in the observation group were significantly lower than those in the control group after treatment（P<0.05）.There was no significant difference in the score of ability of daily living of patients between the two groups before treatment （P>0.05）.The score of ability of daily living of patients after treatment were significantly higher than those before treatment in the two groups （P<0.05）.The score of ability of daily living of patients in the observation group was significantly higher than that in the control group after treatment （P<0.05）.There was no significant difference in whole blood low shear viscosity，erythrocyte aggregation index，whole blood reduced viscosity，platelet aggregation rate and fibrinogen level between the two groups before treatment （P>0.05）.The whole blood low shear viscosity，erythrocyte aggregation index，whole blood reduced viscosity，platelet aggregation rate and fibrinogen level after treatment were significantly lower than those before treatment in the two groups （P<0.05）.The whole blood low shear viscosity，erythrocyte aggregation index，whole blood reduction viscosity，platelet aggregation rate and fibrinogen level in the observation group were significantly lower than those in the control group after treatment （P<0.05）.Conclusion　Batroxobin can significantly improve the hemorheology and neurological function of ACI patients，and improve their ability of daily living.

参考文献/References:

［1］　申丽红，梁小乐，高旭光.急性脑梗死患者微栓子与颈动脉粥样硬化斑块的相关性研究［J］.中华老年心脑血管病杂志，2014，16（3）：237-239.

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更新日期/Last Update: 2019-06-05