[1]陈　翔,张　琰,陆宝华,等.苦参素型锌指蛋白4在甲状腺癌组织中的表达及临床意义[J].新乡医学院学报,2019,36(6):540-543.[doi:10.7683/xxyxyxb.2019.06.010]
　CHEN Xiang,ZHANG Yan,LU Bao-hua,et al.Expression and clinical significance of zinc finger matrin-type 4 in thyroid carcinoma tissue[J].Journal of Xinxiang Medical University,2019,36(6):540-543.[doi:10.7683/xxyxyxb.2019.06.010]
点击复制

苦参素型锌指蛋白4在甲状腺癌组织中的表达及临床意义
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年6
页码:
540-543
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Expression and clinical significance of zinc finger matrin-type 4 in thyroid carcinoma tissue
作者:
陈　翔; 张　琰; 陆宝华; 陈　勇; 刘利敏
（上海市宝山区中西医结合医院甲状腺外科，上海　201999）
Author(s):
CHEN Xiang; ZHANG Yan; LU Bao-hua; CHEN Yong; LIU Li-min
（Department of Thyroid Surgery，Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine，Shanghai 201999，China）
关键词:
苦参素型锌指蛋白4; 甲状腺癌; 癌症基因图谱数据库; 生物信息学
Keywords:
zinc finger matrin-type 4; thyroid carcinoma; the Cancer Genome Atlas; bioinformatics
分类号:
R736.1
DOI:
10.7683/xxyxyxb.2019.06.010
文献标志码:
A
摘要:
目的　探讨甲状腺癌组织中苦参素型锌指蛋白4（ZMAT4）基因的表达及临床意义。方法　利用癌症基因图谱数据库（TCGA）检索包含ZMAT4 mRNA表达值与对应生存预后资料的497例甲状腺癌患者的信息，在线利用UALCAN数据库检索ZMAT4在甲状腺癌中的表达数据，分析ZMAT4 mRNA水平在甲状腺癌组织与对应的正常甲状腺组织中的表达差异，并分析甲状腺癌组织中ZMAT4 mRNA表达与相应临床病理参数的关系。采用Kaplan-Meier生存分析比较甲状腺癌患者不同临床病理参数下ZMAT4 mRNA表达与总生存期（OS）的关系；并根据临床病理特征分析不同亚组中ZMAT4 mRNA表达与OS的关系。结果　TCGA数据库分析结果显示，甲状腺癌组织中ZMAT4 mRNA的相对表达量显著低于正常甲状腺组织（P<0.01）。甲状腺癌组织中ZMAT4 mRNA的表达与组织学类型、TNM分期、T分期、N分期有关（χ2=59.604、10.705、8.535、31.234，P<0.01），与患者的性别、年龄、M分期、肿瘤多灶性、肿瘤大小、根治程度无关（χ2=0.000、2.851、0.016、0.374、0.221、4.330，P>0.05）。Kaplan-Meier生存曲线显示，ZMAT4 mRNA高表达组患者的OS低于低表达组（Log Rank=8.767，P<0.05）；TNM分期Ⅰ+Ⅱ期、Ⅲ+Ⅳ期患者中，ZMAT4 mRNA高表达组患者的OS低于低表达组（Log Rank=10.291、6.148，P<0.05）；在乳头状癌、N0分期患者中，ZMAT4 mRNA高表达组患者的OS低于低表达组（Log Rank=11.586、11.807，P<0.05）。结论　ZMAT4低表达与甲状腺癌的发生、发展相关，是候选的抑癌基因。ZMAT4基因的表达与甲状腺癌的OS关系密切。
Abstract:
Objective　To investigate the expression and clinical significance of zinc finger matrin-type 4 （ZMAT4） gene in thyroid cancer tissue.Methods　The Cancer Genome Atlas （TCGA） was used to retrieve and screen the information of 497 cases of thyroid cancer with ZMAT4 mRNA expression value and corresponding survival data.The expression data of ZMAT4 in thyroid cancer were retrieved by using online UALCAN database，and the difference of the expression of ZMAT4 mRNA in thyroid cancer and normal thyroid tissue was analyzed.The relationship between the expression of ZMAT4 mRNA in thyroid carcinoma and clinicopathological parameters was analyzed.The relationship between the expression of ZMAT4 mRNA and total survival time （OS） in thyroid cancer patients with different clinicopathological parameters was analyzed by Kaplan-Meier survival analysis.Results　The results of TCGA database showed that the relative expression of ZMAT4 mRNA in thyroid cancer tissue was significantly lower than that in normal thyroid tissue （P<0.01）.The expression of ZMAT4 mRNA was correlated with histological type，TNM stage，T stage and N stage （χ2=59.604，10.705，8.535，31.234；P<0.01），but it was not correlated with gender，age，M stage，multifocal tumors，tumor size and radical degree （χ2=0.000，2.851，0.016，0.374，0.221，4.330；P>0.05）.Kaplan-Meier survival curve showed that the OS of patients with high expression of ZMAT4 mRNA was lower than that of patients with low expression （Log Rank=8.767，P<0.05）；the OS of patients with high expression of ZMAT4 mRNA was lower than that of patients with low expression in TNM stage Ⅰ+Ⅱ and Ⅲ+Ⅳ patients（Log Rank=10.291，6.148；P<0.05）；the OS of patients with high expression of ZMAT4 mRNA was lower than that of patients with low expression in papillary cancer and N0 stage patiens （Log Rank=11.586，11.807；P<0.05）.Conclusion　The low expression of ZMAT4 is associated with the occurrence and development of thyroid carcinoma，and it is a candidate oncogene.The expression of ZMAT4 mRNA is closely related to the survival time of thyroid cancer

参考文献/References:

［1］　陈万青，李贺，孙可欣，等.2014年中国恶性肿瘤发病和死亡分析［J］.中华肿瘤杂志，2018，40（1）：5-13.
［2］　鲍萍萍，吴春晓，张敏璐，等.2015年上海市恶性肿瘤流行特征分析［J］.中国癌症杂志，2019，29（2）：81-99.
［3］　LIU W，YUAN W，LI X，et al.ZNF424 induces apoptosis and inhibits proliferation in lung carcinoma cells［J］.Curr Mol Med，2018，18（2）：109-115.
［4］　LI Y，YANG Q，GUAN H，et al.ZNF677 suppresses Akt phosp-horylation and tumorigenesis in thyroid cancer［J］.Cancer Res，2018，78（18）：5216-5228.
［5］　WANG V W，LABORDE R R，ASMANN Y W，et al.Search for chromosome rearrangements：new approaches toward discovery of novel translocations in head and neck squamous cell carcinoma［J］.Head Neck，2013，35（6）：831-835.
［6］　CHANDRASHEKAR D S，BASHEL B，BALASUBRAMANYA S A H，et al.UALCAN：a portal for facilitating tumor subgroup gene expression and survival analyses［J］.Neoplasia，2017，19（8）：649-658.
［7］　LEE M S，GIPPERT G P，SOMAN K V，et al.Three-dimensional solution structure of a single zinc finger DNA-binding domain［J］.Science，1989，245（4918）：635-637.
［8］　TUPLER R，PERINI G，GREEN M R.Expressing the human genome［J］.Nature，2001，409（6822）：832-833.
［9］　CASSANDRI M，SMIRNOV A，NOVELLI F，et al.Zinc-finger proteins in health and disease［J］.Cell Death Discov，2017，3：17071.
［10］　WAN J，GAO Y，ZHAO X，et al.The association between the copy-number variations of ZMAT4 and hematological malignancy［J］.Hematology，2011，16（1）：20-23.
［11］　VAN VELSEN E F S，STEGENGA M T，VAN KEMENADE F J，et al.Comparing the prognostic value of the eighth edition of the American joint committee on cancer/tumor node metastasis staging system between papillary and follicular thyroid cancer［J］.Thyroid，2018，28（8）：976-981.
［12］　SHI L Y，LIU J，YU L J，et al.Clinic-pathologic features and prognostic analysis of thyroid cancer in the older adult：a seer based study［J］.J Cancer，2018，9（15）：2744-2750.
［13］　AMIN M B，GREENE F L，EDGE S B，et al.The eighth edition AJCC cancer staging manual：continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging［J］.CA Cancer J Clin，2017，67（2）：93-99.

相似文献/References:

[1]赵巍星,相里昆.甲状腺癌颅骨转移一例报告[J].新乡医学院学报,1986,3(02):072.
[2]周勇,陈玉君.保留颈丛的功能性颈清扫术在甲状腺癌手术的应用 [J].新乡医学院学报,2007,24(01):076.
[3]代立媛,吴俊福,张　旭,等.橄榄油标记对甲状腺癌患者行甲状腺癌根治术和颈部淋巴结清扫术后乳糜漏的预防作用[J].新乡医学院学报,2021,38(4):345.[doi:10.7683/xxyxyxb.2021.04.010]
　DAI Liyuan,WU Junfu,ZHANG Xu,et al.Preventive effect of olive oil tracer on chylous leakage after radical thyroidectomy and radical neck dissection in patients with thyroid cancer[J].Journal of Xinxiang Medical University,2021,38(6):345.[doi:10.7683/xxyxyxb.2021.04.010]
[4]李　鹏,罗瑞华,郭兰伟,等.开放性甲状腺癌手术患者术后出血相关危险因素分析[J].新乡医学院学报,2020,37(3):274.[doi:10.7683/xxyxyxb.2020.03.018]
　LI Peng,LUO Ruihua,GUO Lanwei,et al.Analysis of related risk factors of postoperative hemorrhage in patients undergoing open thyroid cancer operation[J].Journal of Xinxiang Medical University,2020,37(6):274.[doi:10.7683/xxyxyxb.2020.03.018]
[5]陈贵金.瑞芬太尼联合丙泊酚对老年甲状腺癌根治术患者应激反应和炎症反应的影响[J].新乡医学院学报,2020,37(3):246.[doi:10.7683/xxyxyxb.2020.03.011]
　CHEN Guijin.Effect of remifentanil combined with propofol on stress response and inflammatory response in elderly patients undergoing radical thyroidectomy[J].Journal of Xinxiang Medical University,2020,37(6):246.[doi:10.7683/xxyxyxb.2020.03.011]
[6]张兆宏,刘　翔,王兆阳,等.全乳晕腔镜甲状腺癌根治术对甲状腺癌患者喉返神经的影响[J].新乡医学院学报,2020,37(8):743.[doi:10.7683/xxyxyxb.2020.08.009]
　ZHANG Zhaohong,LIU Xiang,WANG Zhaoyang,et al.Effect of total areola endoscopic thyroidectomy on the recurrent laryngeal nerve in patients with thyroid cancer[J].Journal of Xinxiang Medical University,2020,37(6):743.[doi:10.7683/xxyxyxb.2020.08.009]

更新日期/Last Update: 2019-06-05