[1]魏　亮,张小峰,张军峰.阿替普酶治疗急性脑梗死疗效观察[J].新乡医学院学报,2019,36(6):533-535.[doi:10.7683/xxyxyxb.2019.06.008]
　WEI Liang,ZHANG Xiao-feng,ZHANG Jun-feng.Effect of alteplase on acute cerebral infarction[J].Journal of Xinxiang Medical University,2019,36(6):533-535.[doi:10.7683/xxyxyxb.2019.06.008]
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阿替普酶治疗急性脑梗死疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年6
页码:
533-535
栏目:
临床研究
出版日期:
2019-06-05

文章信息/Info

Title:
Effect of alteplase on acute cerebral infarction
作者:
魏　亮1; 张小峰2; 张军峰3
（1.长安医院神经内科，陕西　西安　710016；2.西安凤城医院神经内科，陕西　西安　710016；3.西安医学院人体解剖学教研室，陕西　西安　710021）
Author(s):
WEI Liang1; ZHANG Xiao-feng2; ZHANG Jun-feng3
(1.Department of Neurology,Chang′an Hospital,Xi′an 710016,Shaanxi Province,China;2.Department of Neurology,Xi′an Fengcheng Hospital,Xi′an 710016,Shaanxi Province,China;3.Department of Human Anatomy,Xi′an Medical University,Xi′an 710021,Shaanxi Province,China)
关键词:
急性脑梗死; 阿替普酶; 静脉溶栓; 神经功能
Keywords:
acute cerebral infarction; alteplase; intravenous thrombolysis; neurological function
分类号:
R743.33
DOI:
10.7683/xxyxyxb.2019.06.008
文献标志码:
A
摘要:
目的　探讨阿替普酶治疗急性脑梗死（ACI）的临床效果。方法　选择2015年3月至2018年3月长安医院收治的115例ACI患者为研究对象，按照治疗方法分为观察组（58例）和对照组（57例）。2组患者均给予补液、维持水电解质平衡、营养神经及调节血压、血脂、血糖等常规治疗，观察组患者在常规治疗基础上给予阿替普酶静脉溶栓治疗。治疗前及治疗后1、7 d，采用酶联免疫吸附试验检测患者血清中S100B、神经元特异性烯醇化酶（NSE）、丙二醛（MDA）、8-羟基脱氧鸟嘌呤（8-OHdG）水平，应用美国国立卫生研究院卒中量表（NIHSS）进行神经功能缺损评分；治疗前及治疗后7、15 d，应用Barthel指数进行日常生活能力评分。结果　2组患者治疗前血清NSE、S100B、MDA及 8-OHdG 水平比较差异无统计学意义（P>0.05），2组患者治疗后1、7 d血清NSE、S100B、MDA及8-OHdG水平显著低于治疗前（P<0.05），2组患者治疗后7 d血清NSE、S100B、MDA及8-OHdG水平显著低于治疗后1 d（P<0.05）；治疗后1、7 d，观察组患者血清NSE、S100B、MDA及8-OHdG水平显著低于对照组（P<0.05）。2组患者治疗前NIHSS评分比较差异无统计学意义（P>0.05），2组患者治疗后1、7 d NIHSS评分显著低于治疗前（P<0.05），2组患者治疗后7 d NIHSS评分显著低于治疗后1 d（P<0.05）；治疗后1、7 d，观察组患者NIHSS评分显著低于对照组（P<0.05）。2组患者治疗前日常生活能力评分比较差异无统计学意义（P>0.05），2组患者治疗后7、15 d日常生活能力评分显著高于治疗前（P<0.05），2组患者治疗后15 d日常生活能力评分显著高于治疗后7 d（P<0.05）；治疗后7、15 d，观察组患者日常生活能力评分显著高于对照组（P<0.05）。结论　阿替普酶静脉溶栓治疗可以显著改善ACI患者神经功能，提高患者日常生活能力。
Abstract:
Objective　To investigate the clinical effect of alteplase in the treatment of acute cerebral infarction (ACI).Methods　A total of 115 patients with ACI admitted to Chang′an Hospital from March 2015 to March 2018 were selected as the study subjects,and the patients were divided into observation group (n=58) and control group (n=57) according to the treatment method.The patients in the two groups were given routine treatment such as fluid infusion,maintaining water and electrolyte balance,neurotrophic therapy and regulating blood pressure,blood lipid and blood sugar.The patients in the observation group were given intravenous thrombolysis with alteplase on the basis of routine treatment.The levels of serum S100B,neuron specific enolase (NSE),malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were detected by enzyme-linked immunosorbent assay;and the neurologic impairment score was evaluated by the National Institutes of Health Stroke Scale (NIHSS) before and at one,seven days after treatment.The ability of daily living was evaluated by Barthel index before and at 7,15 days after treatment.Results　There was no significant difference in the level of serum NSE,S100B,MDA and 8-OHdG between the two groups before treatment (P>0.05).The levels of serum NSE,S100B,MDA and 8-OHdG at one and seven days after treatment were significantly lower than those before treatment in the two groups (P<0.05).The levels of serum NSE,S100B,MDA and 8-OHdG at seven days after treatment were significantly lower than those at one day after treatment in the two groups (P<0.05).The levels of serum NSE,S100B,MDA and 8-OHdG in the observation group were significantly lower than those in the control group at one and seven days after treatment (P<0.05).There was no significant difference in the NIHSS score between the two groups before treatment (P>0.05).The NIHSS score at one and seven days after treatment was significantly lower than that before treatment in the two groups (P<0.05).The NIHSS score at seven days after treatment was significantly lower than that at one day after treatment in the two groups (P<0.05).The NIHSS score in the observation group was significantly lower than that in the control group at one and seven days after treatment (P<0.05).There was no significant difference in the score of activity of daily living between the two groups before treatment (P>0.05).The score of ability of daily living was significantly higher at 7 and 15 days after treatment than that before treatment in the two groups (P<0.05).The score of ability of daily living at 15 days after treatment was significantly higher than that at 7 days after treatment in the two groups (P<0.05).The score of ability of daily living in the observation group was significantly higher than that in the control group at 7 and 15 days after treatment (P<0.05).Conclusion　Alteplase intravenous thrombolysis can significantly improve the neurological function and ability of daily living of ACI patients.

参考文献/References:

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更新日期/Last Update: 2019-06-05