[1]岳瀚勋,余 娴.细胞穿膜肽药物载体研究进展[J].新乡医学院学报,2019,36(4):397-400.[doi:10.7683/xxyxyxb.2019.04.024]
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细胞穿膜肽药物载体研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年4
页码:
397-400
栏目:
综述
出版日期:
2019-04-05

文章信息/Info

作者:
岳瀚勋1余 娴2
(1.重庆医科大学药学院,重庆 400010;2.重庆医科大学附属第二医院Ⅰ期临床试验研究室,重庆 400010)
关键词:
细胞穿膜肽药物载体靶向性稳定性内体逃逸
分类号:
R96
DOI:
10.7683/xxyxyxb.2019.04.024
文献标志码:
A
摘要:
细胞穿膜肽(CPP)是一类具有穿透细胞膜功能的小分子多肽,能携带多种生物活性分子进入细胞。随着对CPP研究的深入,发现其存在抗蛋白酶水解稳定性差、内体逃逸率低和缺乏靶向性等问题,严重限制其作为药物载体的应用。为了克服这些问题,完善CPP的药物载体功能,广大研究者提出了许多改进策略。本文主要就其改进策略加以综述,以期为CPP的改进提供新的思路。

参考文献/References:

[1] WALRANT A,CARDON S,BURLINA F,et al.Membrane crossing and membranotropic activity of cell-penetrating peptides:dangerous liaisons[J].Acc Chem Res,2017,50(12):2968-2975.
[2] BORRELLI A,TORNESELLO A L,TORNESELLO M L,et al.Cell penetrating peptides as molecular carriers for anti-cancer agents[J].Molecules,2018,23(2):E295.
[3] FRANKEL A D,PABO C O.Cellular uptake of the tat protein from human immunodeficiency virus[J].Cell,1988,55(6):1189-1193.
[4] KLIMPEL A,LUTZENBURG T,NEUNDORF I.Recent advances of anti-cancer therapies including the use of cell-penetrating peptides[J].Curr Opin Pharmacol,2019,47:8-13.
[5] DERAKHSHANKHAH H,JAFARI S.Cell penetrating peptides:a concise review with emphasis on biomedical applications[J].Biomed Pharmacother,2018,108:1090-1096.
[6] GALLO M,DEFAUS S,ANDREU D.1988-2018:thirty years of drug smuggling at the nano scale.Challenges and opportunities of cell-penetrating peptides in biomedical research[J].Arch Biochem Biophys,2019,661:74-86.
[7] GUIDOTTI G,BRAMBILLA L,ROSSI D.Cell-penetrating peptides:from basic research to clinics[J].Trends Pharmacol,2017,38(4):406-424.
[8] LECHER J C,NOWAK S J,MCMURRY J L.Breaking in and busting out:cell-penetrating peptides and the endosomal escape problem[J].Biomol Concepts,2017,8(3/4):131-141.
[9] HE Y,LI F,HUANG Y Z.Smart cell-penetrating peptide-based techniques for intracellular delivery of therapeutic macromolecules[J].Adv Protein Chem Struct Biol,2018,112:183-220.
[10] SARKO D,BEIJER B,GARCIA B R,et al.The pharmacokinetics of cell-penetrating peptides[J].Mol Pharm,2010,7(6):2224-2231.
[11] DE LUCIO H,GAMO A M,RUZI-SANTAQUITERIA M,et al.Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides[J].Eur J Med Chem,2017,140:615-623.
[12] KLEIN M J,SCHMIDT S,WADHWANI P,et al.Lactam-stapled cell-penetrating peptides:cell uptake and membrane binding properties[J].J Med Chem,2017,60(19):8071-8082.
[13] ROBERTSON N S,SPRING D R.Using peptidomimetics and constrained peptides as valuable tools for inhibiting protein-protein interactions[J].Molecules,2018,23(4):959-977.
[14] WOLFE J M,FADZEN C M,HOLDEN R L,et al.Perfluoroaryl bicyclic cell-penetrating peptides for delivery of antisense oligonucleotides[J].Angew Chem Int Ed Engl,2018,57(17):4756-4759.
[15] KALAFATOVIC D,GIRALT E.Cell-penetrating peptides:design strategies beyond primary structure and amphipathicity[J].Molecules,2017,22(11):E1929.
[16] KEBEBE D,LIU Y,WU Y,et al.Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers[J].Int J Nanomedicine,2018,13:1425-1442.
[17] 马严.可在体实现胞内直接投递的新型细胞穿膜肽的构建、筛选和穿膜机制研究[D].武汉:华中科技大学,2012.
[18] PEI D,BUYANOVA M.Overcoming endosomal entrapment in drug delivery[J].Bioconjug Chem,2019,30(2):273-283.
[19] NAJJAR K,ERAZO-OLIVERAS A,MOSIOR J W,et al.Unlocking endosomal entrapment with supercharged arginine-rich peptides[J].Bioconjug Chem,2017,28(12):2932-2941.
[20] NEUNDORF I,RENNERT R,HOYER J,et al.Fusion of a short HA2-derived peptide sequence to cell-penetrating peptides improves cytosolic uptake,but enhances cytotoxic activity[J].Pharmaceuticals,2009,2(2):49-65.
[21] KUMAR V,AGRAWAL P,KUMAR R,et al.Prediction of cell-penetrating potential of modified peptides containing natural and chemically modified residues[J].Front Microbiol,2018,9:725-735.
[22] SILVA S,ALMEIDA A J,VALE N.Combination of cell-penetrating peptides with nanoparticles for therapeutic application:a review[J].Biomolecules,2019,9(1):22-46.
[23] YE J,LIU E,YU Z,et al.CPP-assisted intracellular drug delivery,what is next[J].Int J Mol Sci,2016,17(11):1892-1908.
[24] KUMAR M,TEGGE W,WANGOO N,et al.Insights into cell penetrating peptide conjugated gold nanoparticles for internalization into bacterial cells[J].Biophys Chem,2018,237:38-46.
[25] QIN H,DING Y,MUJEEB A,et al.Tumor microenvironment targeting and responsive peptide-based nanoformulations for improved tumor therapy[J].Mol Pharmacol,2017,92(3):219-231.
[26] FENI L,NEUNDORF I.The current role of cell-penetrating peptides in cancer therapy[J].Adv Exp Med Biol,2017,1030:279-295.
[27] BORRELLI A,TOMESELLO A L,TOMESELLO M L,et al.Cell penetrating peptides as molecular carriers for anti-cancer agents[J].Molecules,2018,23(2):E295.
[28] SHI N Q,QI X R,XIANG B,et al.A survey on "Trojan Horse" peptides:opportunities,issues and controlled entry to "Troy"[J].J Control Rel,2014,194:53-70.
[29] ZHU L,KATE P,TORCHILIN V P.Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting[J].Acs Nano,2012,6(4):3491-3498.
[30] JIANG T,OLSON E S,NGUYEN Q T,et al.Tumor imaging by means of proteolytic activation of cell-penetrating peptides[J].Proc Nati Acad Sci,2004,101(51):17867-17872.
[31] KEBEBE D,LIU Y,WU Y,et al.Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers[J].Int J Nanomedicine,2018,13:1425-1442.
[32] SUN L,XIE S P,JI X R,et al.MMP-2-responsive fluorescent nanoprobes for enhanced selectivity of tumor cell uptake and imaging[J].Biomater Sci,2018,6(10):2619-2626.
[33] LEE D Y,NOH I,YOO J,et al.pH-controllable cell-penetrating polypeptide that exhibits cancer targeting[J].Acta Biomater,2017,57:187-196.
[34] KALE A A,TORCHILIN V P.Enhanced transfection of tumor cells in vivo using“Smart” pH-sensitive TAT-modified pegylated liposomes[J].J Drug Target,2007,15(7/8):538-545.
[35] ZARO J L,FEI L,SHEN W C.Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery[J].J Control Release,2012,158(3):357-361.
[36] FEI L,YAP L P,CONTI P S,et al.Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide[J].Biomaterials,2014,35(13):4082-4087.
[37] YEH T H,CHEN Y R,CHEN S Y,et al.Selective intracellular delivery of recombinant arginine deiminase(ADI) using pH-sensitive cell penetrating peptides to overcome ADI resistance in hypoxic breast cancer cells[J].Mol Pharm,2016,13(1):262-271.
[38] TANG B Q,ZARO J L,SHEN Y,et al.Acid-sensitive hybrid polymeric micelles containing a reversibly activatable cell-penetrating peptide for tumor-specific cytoplasm targeting[J].J Control Release,2018,279:147-156.
[39] HANSEN M B,VAN GAAL E,MINTEN I,et al.Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes[J].J Control Release,2012,164(1):87-94.
[40] 杨少坤,闫逍,孙伟红,等.可激活的细胞穿透肽:一种应用于疾病诊断和治疗的极具潜力的可活化模式[J].药学学报,2016,51(4):529-535.

更新日期/Last Update: 2019-04-05