[1]毋　涛,朱从健,汤明磊.曲克芦丁脑蛋白水解物治疗颅脑损伤疗效观察[J].新乡医学院学报,2019,36(3):285-287.[doi:10.7683/xxyxyxb.2019.03.020]
　WU Tao,ZHU Cong-jian,TANG Ming-lei.Effect of troxerutin and cerebroprotein hydrolysate in treatment of craniocerebral injury[J].Journal of Xinxiang Medical University,2019,36(3):285-287.[doi:10.7683/xxyxyxb.2019.03.020]
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曲克芦丁脑蛋白水解物治疗颅脑损伤疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年3
页码:
285-287
栏目:
临床研究
出版日期:
2019-03-05

文章信息/Info

Title:
Effect of troxerutin and cerebroprotein hydrolysate in treatment of craniocerebral injury
作者:
毋　涛1; 朱从健1; 汤明磊2
（1.东南大学医学院附属南京同仁医院重症监护病房，江苏　南京　211100；2.东南大学医学院附属南京同仁医院神经外科，江苏　南京　211100）
Author(s):
WU Tao1; ZHU Cong-jian1; TANG Ming-lei2
（1.Intensive Care Unit，Nanjing Tongren Hospital Affiliated to Medical College of Southeast University，Nanjing 211100，Jiangsu Province，China；2.Department of Neurosurgery，Nanjing Tongren Hospital Affiliated to Medical College of Southeast University，Nanjing 211100，Jiangsu Province，China）
关键词:
颅脑损伤; 曲克芦丁脑蛋白水解物; 胞磷胆碱
Keywords:
craniocerebral injury; troxerutin and cerebroprotein hydrolysate; citicoline
分类号:
R651.1+5
DOI:
10.7683/xxyxyxb.2019.03.020
文献标志码:
A
摘要:
目的　探讨曲克芦丁脑蛋白水解物治疗颅脑损伤患者的临床效果。方法　选择2015年1月至2017年1月东南大学医学院附属南京同仁医院收治的130例颅脑损伤患者为研究对象，按治疗方法分为观察组和对照组，每组65例。观察组患者给予曲克芦丁脑蛋白水解物注射液治疗，对照组患者给予胞磷胆碱注射液治疗；均每日1次，连续治疗2周。比较2组患者治疗前后格拉斯哥昏迷量表（GCS）评分、格拉斯哥预后量表（GOS）评分及生活质量评分，并观察临床治疗有效率和不良反应发生情况。结果　观察组和对照组患者临床治疗总有效率分别为93.85%（61/65）和78.46%（51/65），观察组患者临床治疗总有效率高于对照组（χ2=0.221，P<0.05）。治疗前2组患者GCS、GOS、语言功能、运动功能、心理功能、社交功能评分比较差异无统计学意义（P>0.05）。治疗后2组患者GCS、GOS、语言功能、运动功能、心理功能、社交功能评分高于治疗前（P<0.05），且观察组患者GCS、GOS、语言功能、运动功能、心理功能、社交功能评分高于对照组 （P<0.05）。观察组和对照组患者不良反应发生率分别为9.23%（6/65）和12.31%（8/65），2组患者不良反应发生率比较差异无统计学意义（χ2=0.523，P>0.05）。结论　曲克芦丁脑蛋白水解物治疗颅脑损伤临床疗效显著，能够改善患者的昏迷状态、预后效果及生活质量，且用药安全性良好。
Abstract:
Objective　To investigate the clinical effect of troxerutin and cerebroprotein hydrolysate in treatment of craniocerebral injury.Methods　One hundred and thirty craniocerebral injury patients in the Nanjing Tongren Hospital Affiliated to Medical College of Southeast University from January 2015 to January 2017 were selected as the research objects.According to the treatment method，they were divided into observation group and control group，with 65 cases in each group.Patients in the observation group were treated with troxerutin and cerebroprotein hydrolysate injection，while patients in the control group were treated with citicoline injection,once a day for two weeks.The Glasgow coma index score （GCS），Glasgow prognosis grade score （GOS） and quality of life score before and after treatment were compared between the two groups，and the clinical efficacy and adverse reactions were observed.Results　The total clinical effective rate of the observation group and the control group was 93.85%（61/65） and 78.46%（51/65），respectively.The total clinical effective rate of the observation group was higher than that of the control group（χ2=0.221,P<0.05）.There was no statistically significant difference in GCS，GOS and the scores of language function，motor function，psychological function，social function between the two groups before treatment （P>0.05）.The GCS，GOS and the scores of language function，motor function，psychological function，social function of patients in the two groups after treatment were higher than those before treatment （P<0.05），and GCS，GOS scores and the scores of language function，motor function，psychological function，social function of patients in the observation group were higher than those in the control group after treatment （P<0.05）.The incidence of adverse reactions in the observation group and the control group was 9.23%（6/65） and 12.31%（8/65），respectively.There was no statistically significant difference in the incidence of adverse reactions between the two groups （χ2=0.523，P>0.05）.Conclusion　Troxerutin and cerebroprotein hydrolysate has a significant clinical effect in the treatment of craniocerebral injury，which can improve the coma status and prognosis of the patients，improve the quality of life of the patients after treatment，and has good drug safety.

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更新日期/Last Update: 2019-03-05