[1]董 燕,杨英艺,龙泳伶.高强度聚焦超声联合四黄水蜜外敷治疗子宫肌瘤疗效观察[J].新乡医学院学报,2019,36(3):250-253.[doi:10.7683/xxyxyxb.2019.03.011]
 DONG Yan,YANG Ying-yi,LONG Yong-ling.Clinical effect of high intensity focused ultrasound combined with external application of Sihuang shuimi in the treatment of uterine fibroids[J].Journal of Xinxiang Medical University,2019,36(3):250-253.[doi:10.7683/xxyxyxb.2019.03.011]
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高强度聚焦超声联合四黄水蜜外敷治疗子宫肌瘤疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年3
页码:
250-253
栏目:
临床研究
出版日期:
2019-03-05

文章信息/Info

Title:
Clinical effect of high intensity focused ultrasound combined with external application of Sihuang shuimi in the treatment of uterine fibroids
作者:
董 燕1杨英艺1龙泳伶2
(1.广州中医药大学第二附属医院妇科,广东 广州 510000;2.广州中医药大学中药学院,广东 广州 510000)
Author(s):
DONG Yan1YANG Ying-yi1LONG Yong-ling2
(1.Department of Gynecology,the Second Affiliated Hospital of Guangdong University of Traditional Chinese Medicine,Guangzhou 510000,Guangdong Province,China;2.College of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510000,Guangdong Province,China)
关键词:
子宫肌瘤高强度聚焦超声四黄水蜜
Keywords:
uterine fibroidshigh intensity focused ultrasoundSihuang shuimi
分类号:
R737.33
DOI:
10.7683/xxyxyxb.2019.03.011
文献标志码:
A
摘要:
目的 探讨高强度聚焦超声(HIFU)联合四黄水蜜外敷治疗子宫肌瘤的临床效果。方法 选择2016年4月至2018年1月广州中医药大学第二附属医院妇科收治的56例子宫肌瘤患者为研究对象,根据治疗方法将患者分为观察组和对照组,每组28例。对照组患者给予HIFU治疗,观察组患者给予HIFU联合四黄水蜜外敷治疗,均治疗 3 d。治疗后4周比较2组患者的治疗效果,分别于治疗后3、12 h采用视觉模拟评分(VAS)评估患者的疼痛情况,比较2组患者治疗前及治疗后2、4周子宫肌瘤瘤体血流分级情况。结果 对照组和观察组患者治疗总有效率分别为78.57%(22/28)、96.43%(27/28),观察组患者治疗总有效率显著高于对照组(χ2=4.082,P=0.043)。治疗前2组患者子宫肌瘤瘤体血流分级比较差异无统计学意义(Z=0.539,P=0.590)。对照组患者治疗后2周与治疗前子宫肌瘤瘤体血流分级比较差异无统计学意义(Z=0.688,P=0.492),治疗后4周子宫肌瘤瘤体血流分级优于治疗前(Z=2.758,P=0.006)。观察组患者治疗后2、4周子宫肌瘤瘤体血流分级均优于治疗前(Z=3.168、5.366,P=0.002、0.000)。治疗后2、4周,观察组患者子宫肌瘤瘤体血流分级均显著优于对照组(Z=2.068、2.801,P=0.039、0.005)。2组患者治疗前VAS评分比较差异无统计学意义(t=1.866,P=0.068);治疗后3 h,观察组患者VAS评分显著低于治疗前(t=4.584,P=0.000),对照组患者VAS评分与治疗前比较差异无统计学意义(t=1.327,P=0.196);2组患者治疗后12 h VAS评分显著低于治疗前(t=5.730、9.466,P=0.000、0.000),2组患者治疗后12 h VAS评分低于治疗后3 h(t=6.000、8.575,P=0.000、0.000)。治疗后3、12 h,观察组患者VAS评分显著低于对照组(t=2.186、2.571,P=0.033、0.013)结论 HIFU联合四黄水蜜外敷治疗子宫肌瘤效果显著,能够有效减少子宫肌瘤血流,减轻患者的疼痛感。
Abstract:
Objective To investigate the clinical effect of high intensity focused ultrasound(HIFU) combined with external application of Sihuang shuimi in the treatment of uterine fibroids.Methods Fifty-six patients with uterine fibroids in the Department of Gynecology,the Second Affiliated Hospital of Guangdong University of Traditional Chinese Medicine from April 2016 to January 2018 were selected and divided into observation group and control group according to the treatment method,with 28 patients in each group.The patients in the control group were treated with HIFU,the patients in the observation group were treated with HIFU combined with Sihuang shuimi by external application;all patients were treated for 3 days.The therapeutic effect of patients in the two groups were compared at 4 weeks after treatment.The pain of patients at 3,12 h after treatment was evaluated by visual analogue scales(VAS);the blood flow grading of uterine fibroids of patients before treatment and at 2,4 weeks after treatment was compared between the two groups.Results The total effective rate of patients in the control group and observation group was 78.57% (22/28) and 96.43%(27/28),respectively.The total effective rate of patients in the observation group was significantly higher than that in the control group (χ2=4.082,P=0.043).There was no significant difference in blood flow grading of uterine fibroids between the two groups before treatment (Z=0.539,P=0.590).In the control group,there was no significant difference in blood flow grading of uterine fibroids between the two weeks after treatment and before treatment (Z=0.688,P=0.492);the blood flow grading of uterine fibroids at four weeks after treatment was better than that before treatment (Z=2.758,P=0.006).In the observation group,the blood flow grading of uterine fibroids at 2,4 weeks after treatment was better than that before treatment (Z=3.168,5.366;P=0.002,0.000).After 2 and 4 weeks of treatment,the blood flow grading of uterine fibroids in the observation group was significantly better than that in the control group (Z=2.068,2.801;P=0.039,0.005).There was no significant difference in the VAS score of patients between the two groups before treatment (t=1.866,P=0.068).At 3 hours after treatment,the VAS score of patients was significantly lower than that before treatment in the observation group(t=4.584,P=0.000);there was no significant difference in the VAS scores of patients before and 3 hours after treatment in the control group(t=1.327,P=0.196);the VAS score of patients at 12 h after treatment was significantly lower than that before treatment in the two groups(t=5.730,9.466;P=0.000,0.000);the VAS score of patients at 12 hours after treatment was significantly lower than that at 3 hours after treatment in the two groups(t=6.000,8.575;P=0.000,0.000);the VAS score of patients in the observation group was significantly lower than that in the control group at 3 hours and 12 hours after treatment (P<0.05).Conclusion HIFU combined with external application of Sihuang shuimi is effective in the treatment of uterine fibroids.It can effectively reduce the blood flow of the luterine fibroids,and reduce the pain of patients.

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更新日期/Last Update: 2019-03-05