参考文献/References:
［1］ WANG H X,WANG Y P.Gut microbiota-brain axis［J］.Chin Med J (Eng l),2016,1290(19):2373-2380.
［2］ DISTRUTTI E,MONALDI L,RICCI P,et al.Gut microbiota role in irritable bowel syndrome:new therapeutic strategies［J］.World J Gastroenterol,2016,22 (7):2219-2241.
［3］ MAYER E A.Gut feelings:the emerging biology of gut-brain communication［J］.Nat Rev Neurosci,2011,12 (8):453-466.
［4］ SINGH V,ROTH S,LLOVERA G,et al.Microbiota dysbiosis controls the neuroin-flammatory response after stroke［J］.J Neurosci,2016,38(28):7428-7440.
［5］ RHEE S H,POTHOULAKIS C,MAYER E A.Principles and clinical implicateons of the brain-gut-enteric microbiota axis［J］.Nat Rev Gastroenterol Hepatol,2009,6(5):306-314.
［6］ HOULDEN A,GOLDRICK M,BROUGH D,et al.Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production［J］.Brain Behav Immun,2016,57:10-20.
［7］ MACFARLANE S,DILLON J F.Microbial biofilms in the human gastrointestinal tract［J］.J Appl Microbiol,2007,102(5):1187-1196.
［8］ 贺锐，张丽秀，叶萍，等.低出生体重儿肠道菌群及肠道屏障功能的研究［J］.中国微生态学杂志,2017,29(9)：1022-1026.
［9］ STANLEY D,MASON L J,MACKIN K E,et al.Translocation and dissemination of commensal bacteria in post-stroke infection［J］.Nat Med,2016,22 (11):1277-1284.
［10］ 齐志伟,王仲,刘业成,等.紧密连接Occludin蛋白在缺血性脑卒中肠屏障改变中的作用［J］.中国急救医学,2011,31(3)：233-237.
［11］ DE PUNDER K,PRUIMBOOM L.Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability［J］.Front Immunol,2015,6:223.
［12］ WU J，FAN C L,MA L J,et al.Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients［J］.Thromb Haemost,2017,117(5):992-1001.
［13］ NAKATA K,SUGI Y,NARABAYASHI H,et al.Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4［J］.J Biol Chem,2017,292(37):15426-15433.
［14］ BANKS W A,ERICKSON M A.The blood-brain barrier and immune function and dysfunction［J］.Neurobiol Dis,2010,37(1):26-32.
［15］ LI J，YUAN M，LIU Y,et al.Incidence of constipation in stroke patients:a systematic review and meta-analysis［J］.Medicine (Baltimore),2017,96(25):e7225.
［16］ CAMARA-LEMARROY C R,IBARRA-YRUEGAS B E,GONGORA-RIVERA F.Gast-rointestinal complications after ischemic stroke［J］.J Neurol Sci,2014,346(1/2):20-25.
［17］ KROGH K,CHRISTENSEN P,LAURBERG S.Colorectal symptoms in patients with neurological diseases［J］.Acta Neurol Scand,2001,103(6):335-343.
［18］ 窦迎春,许倩倩,孟欣颖.脑肠肽及焦虑、抑郁在便秘中的研究进展［J］.胃肠病学和肝病学杂志,2017,26(5):497-502.
［19］ MAYER E A,TILLISCH K,GUPTA A.Gut/brain axis and the microbiota［J］.J Clin Invest,2015,125(3):926-938.
［20］ PATRA S,MUTHURAMAN M S,MEENU M,et al.Antiinflammatory effects of royal poinciana through inhibition of toll-like receptor 4 signaling pathway［J］.Int Immunopharmacol,2016,34:199-211.
［21］ NIGHOT M,AL-SADI R,GUO S,et al.Lipopolysaccharide-induced increase in intestinal epithelial tight permeability is mediated by Toll-like receptor 4/myeloid differentiation primary response 88 (MyD88)activation of myosin light chain kinase expression［J］.Am J Pathol,2017,187 (12):2698-2710.
［22］ 覃兰惠,黄文,莫雪安,等.脂多糖诱导血脑屏障破坏中JNK信号通路与基质金属蛋白酶-9作用机制的研究［J］.中风与神经疾病杂志，2015,32(5):388-393.
［23］ MCCUSKER R H,KELLEY K W.Immuneneural connections:how the immune system′s response to infectious agents influences behavior［J］.J Exp Biol,2013,216 (Pt1):84-98.
［24］ STANLEY D,MASON L J,MACKIN K E,et al.Translocation and dissemination of commensal bacteria in post-stroke infection［J］.Nat Med,2016,22(11):1277-1284.
［25］ SANTOS SAMARY C，PELOSI P，LEME SILVA P,et al.Immunomodulation after ischemic stroke:potential mechanisms and implications fortherapy［J］.Crit Care,2016,20(1):391.
［26］ 范文涛,闫咏梅,别玉龙,等.大鼠卒中后肠道菌群紊乱与抑郁的关系［J］中国脑血管病杂志,2016,23(12):644-649.
［27］ LUCZYNSKI P,MCVEY NEUFELD K A,ORIACH C S,et al.Growing up in a bubble:using germ-free animals to assess the influence of the gut microbiota on brain and behavior［J］.Int J Neuropsychopharmacol,2016,19 (18):1-17.
［28］ HU X,LI P,GUO Y,et al.Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia［J］.Stroke,2012,43(11):3063-3070.
［29］ D′MELLO C,RONAGHAN N,ZAHEER R,et al.Probiotics improve inflammation-associated sickness behavior by altering communication between the peripheral immune system and the brain［J］.J Neurosci,2015,35(30):10821-10830.
［30］ IADECOLA C,ANRATHER J.The immunology of stroke:from mechanisms to translation［J］.Nat Med,2011,17(7):796-808.
［31］ BODHANKAR S,CHEN Y,LAPATO A,et al.Regulatory CD8+CD122+ T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells［J］.Metab Brain Dis,2015,30(4):911-924.
［32］ SINGH B,READ S,ASSEMAN C,et al.Control of intestinal inflammation by regulatory T cells［J］.Immunol Rev,2001,182:190-200.
［33］ PRINZ I,SILVA-SANTOS B,PENNINGTON D J.Functional development of γδT cells［J］.Eur J Immunol,2013,43(8):1988-1994.
［34］ BENAKIS C,BREA D,CABALLERO S,et al.Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδT cells［J］.Nat Med,2016,22(5):516-523.
［35］ 罗霞,罗爽,郑彦懿,等.肠道菌群失调增加小鼠肠上皮内T淋巴细胞活化和促炎细胞因子分泌［J］.细胞与分子免疫学杂志,2016,32(8)：1031-1035.
相似文献/References:
[1]张秀敏.带蒂大网膜—脑移植术治疗缺血性脑卒中的护理[J].新乡医学院学报,1985,2(02):010.
[2]宋伟。 蔺志清,夏国庆,遣燕燕.超早期选择性动脉溶栓治疗急性缺血性脑卒中13例[J].新乡医学院学报,2002,19(06):496.
[3]刘大建,赵美英,贺维亚,等.缺血性脑卒中患者颅外段颈动脉狭窄的临床特点及危险因素 [J].新乡医学院学报,2007,24(04):370.
[4]马晓瑭,潘群文,何彩霞,等. ＭｉｃｒｏＲＮＡ１２５ａ对缺血性脑卒中小鼠内皮祖细胞功能的调节作用[J].新乡医学院学报,2015,32(08):702.
[5]王小瑞,郑献召,韩凯,等.沙格列汀对2型糖尿病伴缺血性脑卒中患者血糖水平及认知功能的影响[J].新乡医学院学报,2022,39(12):1163.[doi:10.7683/xxyxyxb.2022.12.012]
WANG Xiaorui,ZHENG Xianzhao,HAN Kai,et al.Effect of saxagliptin on blood glucose level and cognitive function of patients with type 2 diabetes and ischemic stroke[J].Journal of Xinxiang Medical University,2022,39(2):1163.[doi:10.7683/xxyxyxb.2022.12.012]
[6]严宝剑,崔文帅.脑卒中独立急救模式对急性缺血性脑卒中治疗效果及预后的影响[J].新乡医学院学报,2021,38(4):361.[doi:10.7683/xxyxyxb.2021.04.014]
YAN Baojian,CUI Wenshuai.Clinical study on the effect of independent emergency mode of stroke on the treatment effect and prognosis of acute stroke[J].Journal of Xinxiang Medical University,2021,38(2):361.[doi:10.7683/xxyxyxb.2021.04.014]
[7]王伟伟,张保安,熊小云,等.迷走神经电刺激对缺血性脑卒中大鼠脑损伤及Toll样受体4信号通路的影响[J].新乡医学院学报,2020,37(3):225.[doi:10.7683/xxyxyxb.2020.03.006]
WANG Weiwei,ZHANG Baoan,XIONG Xiaoyun,et al.Effect of vagus nerve stimulation on brain injury and Toll-like receptor 4 signaling pathway in rats with cerebral ischemic stroke[J].Journal of Xinxiang Medical University,2020,37(2):225.[doi:10.7683/xxyxyxb.2020.03.006]
[8]郭 升,殷 闯,苏祯磊,等.青年缺血性脑卒中类肝素药物治疗急性缺血性脑卒中试验分型与中国缺血性卒中亚型分型比较[J].新乡医学院学报,2017,34(3):194.[doi:10.7683/xxyxyxb.2017.03.009]
GUO Sheng,YIN Chuang,SU Zhen-lei,et al.Comparison between trial of org 10172 in acute stroke treatment and Chinese ischemic stroke subclassification classification in young patients with cerebral ischemic stroke[J].Journal of Xinxiang Medical University,2017,34(2):194.[doi:10.7683/xxyxyxb.2017.03.009]
[9]刘亚美,李 彤.豫北地区青年缺血性脑卒中危险因素分析[J].新乡医学院学报,2017,34(4):323.[doi:10.7683/xxyxyxb.2017.04.021]
LIU Ya-mei,LI Tong.Analysis of risk factors of young ischemic stroke patients in the north area in Henan province[J].Journal of Xinxiang Medical University,2017,34(2):323.[doi:10.7683/xxyxyxb.2017.04.021]
[10]赵 欣,谭 军.间充质干细胞治疗缺血性脑卒中临床研究现状[J].新乡医学院学报,2017,34(6):545.[doi:10.7683/xxyxyxb.2017.06.026]