[1]华彩红,郝尚辉,赵淑珍,等.滋肾育胎丸联合烯丙雌醇治疗复发性流产的疗效及其对患者性激素水平的影响[J].新乡医学院学报,2019,36(2):139-142.[doi:10.7683/xxyxyxb.2019.02.009]
　HUA Cai-hong,HAO Shang-hui,ZHAO Shu-zhen,et al.Curative effect of Zishen Yutai pills combined with allylestrenol for recurrent abortion and its effect on the levels of sex hormone[J].Journal of Xinxiang Medical University,2019,36(2):139-142.[doi:10.7683/xxyxyxb.2019.02.009]
点击复制

滋肾育胎丸联合烯丙雌醇治疗复发性流产的疗效及其对患者性激素水平的影响
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年2
页码:
139-142
栏目:
临床研究
出版日期:
2019-02-05

文章信息/Info

Title:
Curative effect of Zishen Yutai pills combined with allylestrenol for recurrent abortion and its effect on the levels of sex hormone
作者:
华彩红; 郝尚辉; 赵淑珍; 尹山兰; 张全乐; 雷欢丽
（新乡医学院第一附属医院妇产科，河南　卫辉　453100）
Author(s):
HUA Cai-hong; HAO Shang-hui; ZHAO Shu-zhen; YIN Shan-lan; ZHANG Quan-le; LEI Huan-li
（Department of Obstetrics and Gynecology，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province，China）
关键词:
滋肾育胎丸; 烯丙雌醇; 复发性流产; 性激素; 保胎成功率
Keywords:
Zishen Yutai pill; allylestrenol; recurrent abortion; sex hormone; tocolyis success rate
分类号:
R714.21
DOI:
10.7683/xxyxyxb.2019.02.009
文献标志码:
A
摘要:
目的　探讨滋肾育胎丸联合烯丙雌醇治疗复发性流产的疗效及其对患者性激素水平的影响。方法　选择2015年11月至2017年3月新乡医学院第一附属医院收治的复发性流产患者84例，根据治疗方法将患者分为对照组和观察组，每组42例。2组患者均给予烯丙雌醇5 mg，口服，每日3次，连续用药至第12孕周。观察组患者在此基础上给予滋肾育胎丸5 g，口服，每日3次，持续用药至第12孕周。观察治疗后临床效果及保胎成功率，比较2组患者治疗前后血清性激素水平。结果　观察组和对照组患者治疗总有效率分别为88.10%（37/42）、66.67%（28/42），观察组患者治疗总有效率高于对照组（χ2=5.509，P<0.05）。治疗前2组患者血清人绒毛膜促性腺激素（β-hCG）、黄体酮（P）和雌二醇（E2）水平比较差异无统计学意义（P>0.05）；治疗后2组患者血清β-hCG、P、E2水平均高于治疗前（P<0.05），且观察组患者血清β-hCG、P、E2水平高于对照组（P<0.05）。治疗前2组患者腹胀不适、下腹隐痛、腰膝酸软及阴道出血症状积分比较差异无统计学意义（P>0.05）；治疗后2组患者腹胀不适、下腹隐痛、腰膝酸软及阴道出血症状积分低于治疗前（P<0.05），且观察组患者腹胀不适、下腹隐痛、腰膝酸软及阴道出血得分低于对照组（P<0.05）。观察组和对照组患者的保胎成功率分别为80.95%（34/42）、57.14%（24/42），观察组患者保胎成功率高于对照组（χ2=5.570，P<0.05）。结论　烯丙雌醇联合滋肾育胎丸治疗复发性流产，可有效缓解患者临床症状，改善患者血清性激素水平，提高治疗效果及保胎成功率。
Abstract:
Objective　To investigate the curative effect of Zishen Yutai pills combined with allylestrenol for recurrent abortion and its effect on the levels of sex hormone.Methods　A total of 84 patients with recurrent abortion in the First Affiliated Hospital of Xinxiang Medical University from November 2015 to March 2017 were selected and divided into control group and observation group according to the treatment method，with 42 patients in each group.All patients were given allylestrenol 5 mg orally，three times a day until the 12th gestational week；based on this，the patients in the observation group were given Zishen Yutai pills 5 g orally，three times a day until the 12th gestational week.The serum levels of sex hormone were compared between the two groups before and after treatment；the clinical efficacy and the tocolyis success rate of patients were compared between the two groups after treatment.Results　The total effective rate of patients in the observation group and the control group were 88.10% （37/42） and 66.67% （28/42），respectively；the total effective rate of patients in the observation group was significantly higher than that in the control group （χ2=5.509，P< 0.05）.There was no significant difference in the serum levels of β-human chorionic gonadotropin （β-hCG），progesterone （P） and estradiol （E2） of patients between the two groups before treatment （P>0.05）；the serum levels of β-hCG，P and E2 of patients in the two groups after treatment were significantly higher than those before treatment （P<0.05）；after treatment，the serum levels of β-hCG，P and E2 of patients in the observation group were significantly higher than those in the control group（P<0.05）.There was no significant difference in the clinical symptom scores of abdominal distension discomfort，low abdominal pain，lumbar and knee soreness and vaginal bleeding of patients between the two groups before treatment （P>0.05）；after treatment，the clinical symptom scores of abdominal distension discomfort，low abdominal pain，lumbar and knee soreness and vaginal bleeding of patients in the two groups were lower than those before treatment （P<0.05）；and the clinical symptom scores of abdominal distension discomfort，low abdominal pain，lumbar and knee soreness and vaginal bleeding of patients in the observation group were lower than those in the control group （P<0.05）.The tocolyis success rate of patients in the observation group and control group were 80.95% （34/42） and 57.14% （24/42），respectively；the tocolyis success rate of patients in the observation group was higher than that in the control group （χ2=5.570，P<0.05）.Conclusion　Zishen Yutai pills combined with allylestrenol in the treatment of recurrent abortion can effectively alleviate the clinical symptoms of the patients，improve the serum levels of sex hormone，and improve the treatment effect and the tocolyis success rate.

参考文献/References:

［1］　向英，邓阿黎，金晶.中药补肾活血方联合穴位贴敷治疗封闭抗体阴性复发性流产的疗效及对患者IL-10、TGF-β1 指标的影响［J］.世界中医药，2018，13（6）：1424-1427.
［2］　李娟.利托君联合烯丙雌醇治疗习惯性流产疗效观察［J］.临床医学研究与实践，2017，2（2）：69.
［3］　KARAMI N，BOROUJERDNIA M G，NIKBAKHT R，et al.Enhancement of peripheral blood CD56 dim，cell and NK cell cytotoxicity in women with recurrent spontaneous abortion or in vitro fertilization failure［J］.J Reprod Immunol，2012，95（1/2）：87-92.
［4］　方敏，董毅，张水娟，等.烯丙雌醇联合利托君治疗习惯性流产的临床疗效［J］.中国生化药物杂志，2012，33（5）：665-666.
［5］　李绮环.应用烯丙雌醇联合利托君治疗习惯性流产的临床疗效［J］.中国处方药，2015，13（1）：41-42.
［6］　ROMERO R，KUSANOVIC J P，CHAIWORAPONGSA T，et al.Placental bed disorders in preterm labor，preterm PROM，spontaneous abortion and abruptio placentae［J］.Best Pract Res Clin Obstet Gynaecol，2011，25（3）：313-327.
［7］　曾静.烯丙雌醇联合利托君治疗习惯性流产的临床疗效［J］.临床医学研究与实践，2016，1（5）：76.
［8］　许茜，方海艳，范冬梅.烯丙雌醇联合利托君治疗习惯性流产的疗效观察［J］.中国妇幼保健，2017，32（15）：3591-3593.
［9］　王倩雅.烯丙雌醇联合利托君治疗习惯性流产的疗效分析［J］.哈尔滨医药，2017，37（1）：25-26.
［10］　胡晓华，冯玉，陈影，等.育胎灵煎剂对脾肾亏虚型习惯性流产患者细胞因子的影响［J］.中国中医基础医学杂志，2017，23（5）：674-675.
［11］　李洪波.辨证论治配合西药治疗肾虚型习惯性流产疗效观察［J］.陕西中医，2015，36（2）：172-173.
［12］　国家中药管理局.中医病症诊断疗效标准［M］.北京：中国医药科技出版社，2012：243.
［13］　UNANDER A M，OLDING L B.Habitual abortion：parental sharing of HLA antigens，absence of maternal blocking antibody，and suppression of maternal lymphocytes［J］.Am J Reprod Immunol，2013，4（4）：171-178.
［14］　孔庆颖.探讨烯丙雌醇联合利托君治疗习惯性流产的临床疗效［J］.中国卫生产业，2014，11（31）：121-122.
［15］　RAYMOND E G，SHANNON C，WEAVER M A，et al.First-trimester medical abortion with mifepristone 200 mg and misoprostol：a systematic review［J］.Contraception，2013，87（1）：26-37.
［16］　刘静.烯丙雌醇联合利托君治疗习惯性流产的临床疗效［J］.实用中西医结合临床，2017，17（9）：138-139.
［17］　陈淑琼，谢春红，陈静.淋巴免疫疗法结合中西医治疗习惯性流产45例临床观察［J］.中医药导报，2013，19（12）：145-146.
［18］　陈蓉，周华友，闫清雅.益肾填精助孕方结合免疫治疗习惯性流产疗效观察［J］.广州中医药大学学报，2016，33（5）：642-644.
［19］　肖琼，吕连英，陈世新.人绒毛膜促性腺激素联合保胎灵治疗黄体功能不全习惯性流产的临床疗效分析［J］.山西医药杂志，2014，43（16）：1944-1946.
［20］　赵旭辉，陈文英.自拟补肾消抗安胎方治疗免疫性习惯性流产38例临床观察［J］.中医药导报，2013，19（5）：104-105.
［21］　柳艳芳.滋肾育胎丸联合烯丙雌醇治疗先兆流产的疗效观察［J］.现代药物与临床，2018，33（6）：1444-1447.
［22］　韩凤娟，李佳，田苗，等.滋肾育胎丸联合黄体酮注射液治疗先兆流产患者的临床效果［J］.世界中医药，2018，13（4）：826-829.

更新日期/Last Update: 2019-02-05