参考文献/References:
[1] CHEN W,ZHENG R,BAADE P D,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[2] GROSS G,WAKS T,ESHHAR Z.Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity[J].Proc Natl Acad Sci USA,1989,86(24):10024-10028.
[3] DAI H,WANG Y,LU X,et al.Chimeric antigen receptors modified T-cells for cancer therapy[J].J Natl Cancer Inst,2016,108(7):439.
[4] BEATSON R,TAJADURA-ORTEGA V,ACHKOVA D,et al.The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9[J].Nat Immunol,2016,17(11):1273-1281.
[5] BATLEVI C L,MATSUKI E,BRENTJENS R J,et al.Novel immunotherapies in lymphoid malignancies[J].Nat Rev Clin Oncol,2016,13(1):25-40.
[6] KLOSS C C,CONDOMINES M,CARTELLIERI M,et al.Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells[J].Nat Biotechnol,2013,31(1):71-75.
[7] MUNIAPPAN A,BANAPOUR B,LEBKOWSKI J,et al.Ligand-mediated cytolysis of tumor cells:use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes[J].Cancer Gene Ther,2000,7(1):128-134.
[8] ZUO B L,YAN B,ZHENG G X,et al.Targeting and suppression of HER3-positive breast cancer by T lymphocytes expressing a heregulin chimeric antigen receptor[J].Cancer Immunol Immunother,2018,67(3):393-401.
[9] KUDO K,IMAI C,LORENZINI P,et al.T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing[J].Cancer Res,2014,74(1):93-103.
[10] SENTMAN C L,MEEHAN K R.NKG2D CARs as cell therapy for cancer[J].Cancer J,2014,20(2):156-159.
[11] DUSTIN M L,DEPOIL D.New insights into the T cell synapse from single molecule techniques[J].Nat Rev Immunol,2011,11(10):672-684.
[12] PULE M A,STRAATHOF K C,DOTTI G,et al.A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells[J].Mol Ther,2005,12(5):933-941.
[13] BEZBRADICA J S,MEDZHITOV R.Role of ITAM signaling module in signal integration[J].Curr Opin Immunol,2012,24(1):58-66.
[14] ZHAO Z,CONDOMINES M,VAN DER STEGEN S,et al.Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells[J].Cancer Cell,2015,28(4):415-428.
[15] HOMBACH A A,RAPPL G,ABKEN H.Arming cytokine-induced killer cells with chimeric antigen receptors:CD28 outperforms combined CD28-OX40 "super-stimulation"[J].Mol Ther,2013,21(12):2268-2277.
[16] GRECO R,OLIVEIRA G,STANGHELLINI M T,et al.Improving the safety of cell therapy with the TK-suicide gene[J].Front Pharmacol,2015,6:95.
[17] GARGETT T,BROWN M P.The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target,off-tumor toxicities of chimeric antigen receptor T cells[J].Front Pharmacol,2014,5:235.
[18] DI STASI A,TEY S K,DOTTI G,et al.Inducible apoptosis as a safety switch for adoptive cell therapy[J].N Engl J Med,2011,365(18):1673-1683.
[19] WANG X,CHANG W C,WONG C W,et al.A transgene-encoded cell surface polypeptide for selection,in vivo tracking,and ablation of engineered cells[J].Blood,2011,118(5):1255-1263.
[20] FEDOROV V D,THEMELI M,SADELAIN M.PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses[J].Sci Transl Med,2013,5(215):172-215.
[21] ROYBAL K T,RUPP L J,MORSUT L,et al.Precision tumor recognition by T cells with combinatorial antigen-sensing circuits[J].Cell,2016,164(4):770-779.
[22] RODGERS D T,MAZAGOVA M,HAMPTON E N,et al.Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies[J].Proc Natl Acad Sci USA,2016,113(4):E459-E468.
[23] MA J S,KIM J Y,KAZANE S A,et al.Versatile strategy for controlling the specificity and activity of engineered T cells[J].Proc Natl Acad Sci USA,2016,113(4):E450-E458.
[24] BEATTY G L,HAAS A R,MAUS M V,et al.Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies[J].Cancer Immunol Res,2014,2(2):112-120.
[25] BROWN C E,BADIE B,BARISH M E,et al.Bioactivity and safety of IL13 R alpha2-redirected chimeric antigen receptor CD8+T cells in patients with recurrent glioblastoma[J].Clin Cancer Res,2015,21(18):4062-4072.
[26] ERTL H C,ZAIA J,ROSENBERG S A,et al.Considerations for the clinical application of chimeric antigen receptor T cells:observations from a Recombinant DNA Advisory Committee Symposium held June 15,2010[J].Cancer Res,2011,71(9):3175-3181.
[27] CRADDOCK J A,LU A,BEAR A,et al.Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b[J].J Immunother,2010,33(8):780-788.
[28] DI STASI A,DE ANGELIS B,ROONEY C M,et al.T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model[J].Blood,2009,113(25):6392-6402.
[29] CHINNASAMY D,YU Z,KERKAR S P,et al.Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice[J].Clin Cancer Res,2012,18(6):1672-1683.
[30] CARUANA I,SAVOLDO B,HOYOS V,et al.Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes[J].Nat Med,2015,21(5):524-529.
[31] WANG X,RIVIERE I.Manufacture of tumor- and virus-specific T lymphocytes for adoptive cell therapies[J].Cancer Gene Ther,2015,22(2):85-94.
[32] CHEUNG A S,ZHANG D,KOSHY S T,et al.Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells[J].Nat Biotechnol,2018,36(2):160-169.
[33] SOCKOLOSKY J T,TROTTA E,PARISI G,et al.Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes[J].Science,2018,359(6379):1037-1042.
[34] TORIKAI H,REIK A,LIU P Q,et al.A foundation for universal T-cell based immunotherapy:T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR [J].Blood,2012,119(24):5697-5705.
[35] EYQUEM J,MANSILLA-SOTO J,GIAVRIDIS T,et al.Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection[J].Nature,2017,543(7643):113-117.
[36] FOSTER A E,DOTTI G,LU A,et al.Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor[J].J Immunother,2008,31(5):500-505.
[37] ZHANG T,SENTMAN C L.Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells [J].Cancer Res,2011,71(6):2066-2076.
[38] LONG A H,HASO W M,SHERN J F,et al.4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors[J].Nat Med,2015,21(6):581-590.
[39] PEGRAM H J,LEE J C,HAYMAN E G,et al.Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning[J].Blood,2012,119(18):4133-4141.
[40] LEEN A M,SUKUMARAN S,WATANABE N,et al.Reversal of tumor immune inhibition using a chimeric cytokine receptor[J].Mol Ther,2014,22(6):1211-1220.
[41] PROSSER M E,BROWN C E,SHAMI A F,et al.Tumor PD-L1 co-stimulates primary human CD8+cytotoxic T cells modified to express a PD1:CD28 chimeric receptor[J].Mol Immunol,2012,51(3/4):263-272.
[42] JOHN L B,KERSHAW M H,DARCY P K.Blockade of PD-1 immunosuppression boosts CAR T-cell therapy[J].Oncoimmunology,2013,2(10):e26286.