[1]左百乐,杨 如,王向鹏,等.嵌合抗原受体修饰T细胞的分子设计及发展策略[J].新乡医学院学报,2019,36(2):106-110.[doi:10.7683/xxyxyxb.2019.02.002]
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嵌合抗原受体修饰T细胞的分子设计及发展策略
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年2
页码:
106-110
栏目:
专题报告
出版日期:
2019-02-05

文章信息/Info

作者:
左百乐1杨 如2王向鹏1杨安钢3
(1.新乡医学院医学检验学院 河南省分子诊断与医学检验技术协同创新中心,河南 新乡 453003;2.新乡医学院第一附属医院神经修复重点实验室,河南 卫辉 453100;3.空军军医大学基础医学院免疫学教研室,陕西 西安 710032)
关键词:
嵌合抗原受体修饰T细胞结构设计改良策略安全性有效性
分类号:
R730.51
DOI:
10.7683/xxyxyxb.2019.02.002
文献标志码:
A
摘要:
嵌合抗原受体修饰T细胞(CAR-T)疗法因其强大的治疗潜能及临床试验的确切疗效,已经成为肿瘤免疫治疗的重要手段之一。虽然CAR-T疗法在血液系统肿瘤的治疗中取得了突破性进展,但在实体肿瘤中的治疗效果不太理想,同时伴随着细胞因子风暴、脱靶效应等风险。CAR-T疗法的改良策略有通过引入自杀基因系统、CAR-T激活信号控制系统、限制剂量等来提高安全性;增强CAR-T的归巢、增殖存活能力、突破免疫抑制微环境等来增强有效性。本文从CAR结构设计及CAR-T疗法的安全性、有效性改良策略方面展开综述。

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相似文献/References:

[1]王向鹏,左百乐,王冠玉,等.嵌合抗原受体修饰T细胞治疗实体肿瘤的研究现状[J].新乡医学院学报,2019,36(2):101.[doi:10.7683/xxyxyxb.2019.02.001]

更新日期/Last Update: 2019-02-05