[1]马 建,王 磊,杨海杰.阿尔茨海默病血液生物标志物研究进展[J].新乡医学院学报,2019,36(1):092-95.[doi:10.7683/xxyxyxb.2019.01.021]
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阿尔茨海默病血液生物标志物研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年1
页码:
092-95
栏目:
综述
出版日期:
2019-01-05

文章信息/Info

作者:
马 建王 磊杨海杰
(新乡医学院生命科学技术学院 河南省分子诊断与医学检验技术协同中心,河南 新乡 453003)
关键词:
阿尔茨海默病生物标志物血液标志物
分类号:
R749
DOI:
10.7683/xxyxyxb.2019.01.021
文献标志码:
A
摘要:
阿尔茨海默病(AD)又称老年痴呆症,是一种退行性神经疾病,以记忆障碍、失语、视空间技能损害、执行功能障碍及人格和行为改变等全面性痴呆表现为特征,病因迄今未明。研究显示,AD患者的脑损伤可能在确诊前 10~20 a就已经出现,但目前缺乏简单易用的生物标志物,使AD的诊断和治疗受到严重制约。AD常用的检测标本是脑脊液(CSF),但是,通过腰椎穿刺采集CSF可造成侵入性损伤,大大限制了其在临床中的应用。现有的AD流体生物标志物一定程度上能够显示患病的迹象,但无法准确预测疾病进展或评估临床治疗效果。一些新发现的体液分子,如Tau多肽、神经丝蛋白、自身抗体、miRNA、蛋白激酶等已表现出较高的特异性和灵敏度,对AD具有较好的诊断价值。本文主要对AD的蛋白类、核糖核酸类、无机小分子等生物标志物及新近发现的血液生物标志物进行综述。

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更新日期/Last Update: 2019-01-05