[1]张 剑.母乳强化剂应用时机对极早产儿预后的影响[J].新乡医学院学报,2019,36(1):064-66.[doi:10.7683/xxyxyxb.2019.01.013.]
 ZHANG Jian.Effect of the opportunity of applying human milk fortifier on the prognosis of very premature infants[J].Journal of Xinxiang Medical University,2019,36(1):064-66.[doi:10.7683/xxyxyxb.2019.01.013.]
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母乳强化剂应用时机对极早产儿预后的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年1
页码:
064-66
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Effect of the opportunity of applying human milk fortifier on the prognosis of very premature infants
作者:
张 剑
(驻马店市中心医院新生儿科,河南 驻马店 463000)
Author(s):
ZHANG Jian
(Department of Neonatology,Zhumadian Central Hospital,Zhumadian 463000,Henan Province,China)
关键词:
母乳强化剂应用时机极早产儿预后
Keywords:
human milk fortifierapplication opportunityvery premature childrenPrognosis
分类号:
R723
DOI:
10.7683/xxyxyxb.2019.01.013.
文献标志码:
A
摘要:
目的 探讨母乳强化剂应用时机对极早产儿预后的影响。方法 选择2016年1月至2017年12月于驻马店市中心医院出生的124例极早产儿为研究对象,根据母乳强化剂应用时机将极早产儿分为早期干预组和晚期干预组,每组62例。早期干预组早产儿于经口喂养量达到50 mL·kg-1·d-1时给予母乳强化剂,晚期干预组早产儿于经口喂养量达到100 mL·kg-1·d-1时给予母乳强化剂,连续喂养30 d。分别于干预前及干预后测量2组极早产儿体质量、体长和头围,并计算每日体质量增长量及每周体长和头围增长值;记录2组极早产儿肠外营养时间、住院时间及宫外生长发育迟缓(EUGR)、并发症发生率。结果 干预后,早期干预组极早产儿每日体质量增长量、每周体长增长值显著大于晚期干预组(t=3.827、4.024,P<0.05),但2组极早产儿每周头围增长值比较差异无统计学意义(t=0.052,P>0.05)。2组极早产儿肠外营养时间及住院时间比较差异均无统计学意义(t=0.359、1.026,P>0.05)。早期干预组和晚期干预组极早产儿EUGR发生率分别为30.6%(19/62)、48.4%(30/62),早期干预组极早产儿EUGR发生率低于晚期干预组(χ2=4.050,P<0.05)。早期干预组极早产儿喂养不耐受、院内感染、视网膜病变、支气管发育不良、坏死性小肠结肠炎发生率分别为12.9%(8/62)、27.4%(17/62)、9.7%(6/62)、3.2%(2/62)、11.3%(7/62),并发症发生率为64.5%(40/62);晚期干预组极早产儿喂养不耐受、院内感染、视网膜病变、支气管发育不良、坏死性小肠结肠炎发生率分别为14.5%(9/62)、25.8%(16/62)、14.5%(9/62)、4.8%(3/62)、14.5%(9/62),并发症发生率为75.8%(47/62);2组极早产儿并发症发生率比较差异无统计学意义(χ2=1.872,P>0.05)。结论 早期应用母乳强化剂更有利于极早产儿体格生长发育。
Abstract:
Objective To investigate the effect of the opportunity of applying human milk fortifier on the prognosis of very premature infants.Methods A total of 124 very premature infants in Zhumadian Central Hospital from January 2016 to December 2017 were selected as the subjects.The very premature infants were divided into early intervention group and late intervention group according to the opportunity of applying human milk fortifier,62 premature infants in each group.The preterm infants in the early intervention group were given human milk fortifier when their oral feeding volume reached 50 mL·kg-1·d-1,and the preterm infants in the late intervention group were given human milk fortifier when their oral feeding volume reached 100 mL·kg-1·d-1.All premature infants were fed for 30 days.The body mass,body length and head circumference of the very premature infants in the two groups were measured before and after intervention,and the daily increase of body mass,weekly growth value of body length and head circumference were calculated.The parenteral nutrition time,hospitalization time and the incidence of extrauterine growth restriction (EUGR) and the complications were recorded.Results The daily increase of body mass and weekly growth value of body length of the very premature infants in the early intervention were significantly higher than those in the late intervention group after intervention (t=3.827,4.024;P<0.05).However,there was no significant difference in the weekly growth value of head circumference between the two groups after intervention (t=0.052,P>0.05).There was no significant difference in the parenteral nutrition time and hospitalization time of the very premature infants between the two groups (t=0.359,1.026;P>0.05).The incidence of EUGR in the early intervention group and late intervention group was 30.6% (19/62) and 48.4% (30/62),respectively.The incidence of EUGR in the early intervention group was lower than that in the late intervention group (χ2=4.050,P<0.05).The incidence of feeding intolerance,nosocomial infection,retinopathy,bronchial dysplasia and necrotizing enterocolitis in the early intervention group was 12.9% (8/62),27.4% (17/62),9.7% (6/62),3.2% (2/62) and 11.3% (7/62),respectively;the incidence of complications was 64.5% (40/62).The incidence of feeding intolerance,nosocomial infection,retinopathy,bronchial dysplasia and necrotizing enterocolitis in the late intervention group was 14.5% (9/62),25.8% (16/62),14.5% (9/62),4.8% (3/62) and 14.5% (9/62),respectively;the incidence of complications was 75.8% (47/62).There was no significant difference in the incidence of complications between the two groups (χ2=1.872,P>0.05).Conclusion Early application of human milk fortifier is more conducive to physical growth and development of the very premature infants.

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更新日期/Last Update: 2019-01-05