[1]舒冬冬,宋乃宝.布地奈德联合沙丁胺醇雾化吸入治疗支气管哮喘急性发作疗效观察[J].新乡医学院学报,2018,35(12):1101-1103.[doi:10.7683/xxyxyxb.2018.12.014]
　SHU Dong-dong,SONG Nai-bao.Effect of budesonide combined with salbutamol atomization inhalation in the treatment of acute episode of bronchial asthma[J].Journal of Xinxiang Medical University,2018,35(12):1101-1103.[doi:10.7683/xxyxyxb.2018.12.014]
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布地奈德联合沙丁胺醇雾化吸入治疗支气管哮喘急性发作疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年12
页码:
1101-1103
栏目:
临床研究
出版日期:
2018-12-05

文章信息/Info

Title:
Effect of budesonide combined with salbutamol atomization inhalation in the treatment of acute episode of bronchial asthma
作者:
舒冬冬; 宋乃宝
（合肥京东方医院呼吸科，安徽　合肥　230012）
Author(s):
SHU Dong-dong; SONG Nai-bao
（Department of Respiratory Disease，Hefei BOE Hospital，Hefei 230031，Anhui Province，China）
关键词:
支气管哮喘急性发作期; 布地奈德混悬液; 沙丁胺醇气雾剂; 雾化吸入
Keywords:
acute episode of bronchial asthma; budesonide suspension; salbutamol aerosol; atomization inhalation
分类号:
R562.2+5
DOI:
10.7683/xxyxyxb.2018.12.014
文献标志码:
A
摘要:
目的　探讨布地奈德混悬液联合沙丁胺醇气雾剂雾化吸入治疗支气管哮喘急性发作的临床效果。方法　选择2016年1月至2017年1月合肥京东方医院收治的100例支气管哮喘急性发作期患者作为研究对象，根据治疗方法分为观察组和对照组，每组50例。在常规治疗的基础上，观察组患者给予布地奈德混悬液联合沙丁胺醇气雾剂雾化吸入治疗，对照组患者给予沙丁胺醇气雾剂雾化吸入治疗；比较2组患者咳嗽缓解时间、气促缓解时间、哮鸣音消失时间及治疗前后呼气流速峰值（PEFR）、用力肺活量（FVC）、第1秒用力呼气量（FEV1）、血清免疫球蛋白E（IgE）水平、嗜酸粒细胞（EOS）计数。结果　观察组患者咳嗽缓解时间、气促缓解时间及哮鸣音消失时间显著短于对照组（P<0.05）。治疗前2组患者PEFR、FVC及FEV1比较差异均无统计学意义（P>0.05），2组患者治疗后PEFR、FVC及FEV1显著高于治疗前（P<0.05）；治疗后，观察组患者PEFR、FVC及FEV1显著高于对照组（P<0.05）。治疗前2组患者血清IgE水平及EOS计数比较差异均无统计学意义（P>0.05）；2组患者治疗后血清IgE水平及EOS计数显著低于治疗前（P<0.05）；治疗后，观察组患者血清IgE水平及EOS计数显著低于对照组（P<0.05）。结论　布地奈德混悬液联合沙丁胺醇气雾剂雾化吸入可以快速改善支气管哮喘急性发作患者的临床症状，减轻炎症反应，提高肺功能。
Abstract:
Objective　To investigate the clinical effect of budesonide suspension combined with salbutamol aerosol inhalation in the treatment of acute episode of bronchial asthma.Methods　A total of 100 patients with acute episode of bronchial asthma in Hefei BOE Hospital from January 2016 to January 2017 were selected as the study subjects.The patients were divided into observation group and control group according to the treatment method，50 cases in each group.Based on the conventional therapy,the patients in the observation group were treated with budesonide suspension combined with salbutamol aerosol inhalation，while the patients in the control group were treated with salbutamol aerosol inhalation.The cough relief time，short breath relief time，wheezing sound extinction time and the expiratory peak flow rate （PEFR），forced vital capacity （FVC），forced expiratory volume in one second （FEV1），serum immunoglobulin E （IgE） level and eosinophil （EOS） count before and after treatment were compared between the two groups.Results　The cough relief time，short breath relief time and wheezing sound extinction time in the observation group were significantly shorter than those in the control group （P<0.05）.There was no significant difference in PEFR，FVC and FEV1 between the two groups before treatment （P>0.05）.The PEFR，FVC and FEV1 after treatment were significantly higher than those before treatment in the two groups （P<0.05）.The PEFR，FVC and FEV1 in the observation group were significantly higher than those in the control group after treatment （P<0.05）.There was no significant difference in serum IgE level and EOS count between the two groups before treatment （P>0.05）.The serum IgE level and EOS count after treatment were significantly lower than those before treatment in the two groups （P<0.05）.The serum IgE level and EOS count in the observation group were significantly lower than those in the control group after treatment （P<0.05）.Conclusion　Budesonide suspension combined with salbutamol aerosol inhalation can rapidly improve clinical symptoms，alleviate inflammation and improve lung function in patients with acute episode of bronchial asthma.

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更新日期/Last Update: 2018-12-05