[1]王鹏高,张军喜,蒋丽芳,等.先天性室间隔缺损危险因素分析[J].新乡医学院学报,2018,35(12):1064-1067.[doi:10.7683/xxyxyxb.2018.12.005]
　WANG Peng-gao,ZHANG Jun-xi,JIANG Li-fang,et al.Analysis of the risk factors for congenital ventricular septal defect[J].Journal of Xinxiang Medical University,2018,35(12):1064-1067.[doi:10.7683/xxyxyxb.2018.12.005]
点击复制

先天性室间隔缺损危险因素分析
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年12
页码:
1064-1067
栏目:
临床研究
出版日期:
2018-12-05

文章信息/Info

Title:
Analysis of the risk factors for congenital ventricular septal defect
作者:
王鹏高1; 张军喜2; 蒋丽芳2; 柴　健2; 马颖辉2; 孙盼盼2
（1.郑州大学附属儿童医院胸外科，河南　郑州　450018；2.河南省人口和计划生育科学技术研究院 国家卫生计生委出生缺陷预防重点实验室，河南　郑州　450002）
Author(s):
WANG Peng-gao1; ZHANG Jun-xi2; JIANG Li-fang2; CHAI Jian2; MA Ying-hui2; SUN Pan-pan2
（1.Department of Thoracic and Cardiovascular Surgery，the Children′s Hospital Affiliated to Zhengzhou University，Zhengzhou 450018，Henan Province，China；2.Population and Family Planning Science and Technology Research Institute of Henan Province，National Health and Family Planning Commission Key Laboratory of Birth Defects Prevention，Zhengzhou 450002，Henan Province，China）
关键词:
先天性心脏病; 室间隔缺损; 危险因素
Keywords:
congenital heart disease; ventricular septal defect; risk factor
分类号:
R726.1
DOI:
10.7683/xxyxyxb.2018.12.005
文献标志码:
A
摘要:
目的　探讨先天性室间隔缺损（VSD）发生的相关因素，为先天性VSD的病因学研究及预防措施制定提供依据。方法　选择2014年1月至2017年1月郑州市儿童医院收治的167例先天性VSD患儿为VSD组，另选择符合匹配条件的334例非先天性心脏病患儿为对照组，以问卷调查方式收集2组患儿父母的相关资料，并进行多因素logistic回归分析，筛选VSD发生的危险因素。结果　VSD组患儿父亲有毒有害物质接触、吸烟者比例高于对照组（P<0.05），2组患儿父亲的年龄、职业、文化程度、精神压力、厌食蔬菜等因素比较差异无统计学意义（P>0.05）。VSD组患儿母亲孕前精神压力、孕前未规律服用叶酸、不良妊娠结局、孕早期有毒有害物质接触、孕早期发热、孕早期服用药物者比例高于对照组（P<0.05），2组患儿母亲的年龄、职业、文化程度、孕前有毒有害物质接触、厌食蔬菜、阴道出血等因素比较差异无统计学意义（P>0.05）。多因素logistic回归分析显示，父亲接触有毒有害物质及母亲孕前精神压力、孕早期接触有毒有害物质和孕早期服用药物是VSD发生的危险因素（P<0.05），规律服用叶酸是VSD发生的保护因素（P<0.05）。结论　先天性VSD发病的影响因素较多，父亲接触有毒有害物质及母亲孕前精神压力、孕早期接触有毒有害物质和孕早期服用药物是VSD发生的危险因素，规律服用叶酸是VSD发生的保护因素，应加强健康教育和孕期保健，降低VSD的发生风险。
Abstract:
Objective　To investigate the related factors of congenital ventricular septal defect （VSD），and to provide evidence for the etiology and prevention of congenital VSD.Methods　A total of 167 children with congenital VSD in Zhengzhou Children′s Hospital from January 2014 to January 2017 were selected as VSD group，and 334 children with non-congenital heart disease were selected as control group.The data of the parents of the children were collected by questionnaires，and the risk factors for VSD were screened by multivariate logistic regression analysis.Results　The proportions of father exposed to toxic and harmful substances and smoking in VSD group were higher than those in the control group （P<0.05）.There was no significant difference in the father′s factors of age，occupation，education level，mental stress and anorexia of vegetables between the two groups （P>0.05）.The proportions of mothers who had pregestational mental stress took folic acid regularly before pregnancy，adverse pregnancy outcomes，exposure to toxic and harmful substances in early pregnancy，fever in early pregnancy and drug application in early pregnancy in VSD group were higher than those in the control group （P<0.05）.There were no significant differences in the maternal factors of age，occupation，education level，exposure to toxic and harmful substances before pregnancy，anorexia of vegetables and vaginal bleeding between the two groups （P>0.05）.Multivariate logistic regression analysis showed that father exposure to toxic and harmful substances and the mother with mental stress before pregnancy，exposure to toxic and harmful substances and medication in early pregnancy were the risk factors for VSD （P<0.05）.The regular folic acid intake was a protective factor for VSD （P<0.05）.Conclusion　There are many factors influencing the incidence of congenital VSD.The father′s exposure to toxic and harmful substances and the mother′s mental stress before pregnancy，exposure to toxic and harmful substances and taking drugs in early pregnancy are the risk factors for VSD.The regular use of folic acid is a protective factor for VSD.The health education and prenatal care should be strengthened to reduce the risk of VSD.

参考文献/References:

［1］　李文成，申强，谭瑞明，等.怀化地区0～14岁儿童先心病流行病学调查［J］.包头医学院学报，2016，32（4）：10-11.
［2］　马玲波.先天性心脏病与患儿父母孕前半年及孕期环境因素暴露的相关性研究［J］.中国妇幼保健，2016，31（3）：533-535.
［3］　TANTCHOU TCHOUMI J C，BUTERA G.Profile of cardiac disease in cameroon and impact on health care services［J］.Cardiovasc Diagn Tber，2013，3（4）：236-243.
［4］　WANG C，ZHAN Y，WANG F，et al.Parental occupational exposures to endocrine disruptors and the risk of simple isolated congenital heart defects［J］.Pediatr Cardiol，2015，36（5）：1024-1037.
［5］　SNIJDER C A，VLOT I J，BURDORF A，et al.Congenital heart defects and parental occupational exposure to chemicals［J］.Hum Reprod，2012，27（5）：1510-1517.
［6］　严双琴，顾春丽，刘国栋，等.孕前半年父亲铅暴露与子代先天性心脏病病因的关联［J］.中国优生与遗传杂志，2010，18（6）：119-121.
［7］　ROCHELEAU C M，BERTKE S J，LAWSON C C，et al.Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study［J］.Birth Defects Res A Clin Mol Teratol，2015，103（10）：823-833.
［8］　张清凯，纪昌文，赵征华，等.孕早期精神刺激与子代先天性心脏病的病例对照研究［J］.中国妇幼保健，2015，30（16）：2596-2598.
［9］　CSKY-SZUNYOGH M，VERECZKEY A，KSA Z，et al.Association of maternal diseases during pregnancy with the risk of single ventricular septal defects in the offspring-a population-based case-control study［J］.J Matern Fetal Neonatal Med，2013，26（8）：738-747.
［10］　王定美，黄国英.叶酸补充与先天性心脏病发病关系的人群研究［J］.复旦学报（医学版），2017，44（6）：806-810.
［11］　SUN L C，LAI C C，WANG C Y，et al.Risk factors for infective endocarditish in children with congenital heart diseases：a nationwide population-based case control study［J］.Int J Cardiol，2017，248（2）：126-130.

相似文献/References:

[1]马海燕,杨玉海,孙绍连,等.先天性心脏病单心室一例[J].新乡医学院学报,1993,10(01):026.
[2]常银江,马森林,王守义,等.室间隔缺损合并严重肺动脉高压的外科治疗[J].新乡医学院学报,1996,13(03):251.
[3]许清玉,李红军.室间隔缺损致巨大肺动脉瘤1例[J].新乡医学院学报,1996,13(01):041.
[4]张志东,董安平,袁　龙,等.双腔右心室的外科治疗[J].新乡医学院学报,2000,17(05):365.
[5]乔　刚,胡建国,吴忠仕,等.Glenn 分流术治疗先天性心脏病50 例[J].新乡医学院学报,2006,23(06):611.
[6]朱耀斌,范祥明,李晓锋,等.改良肺动脉灌注在发绀型先天性心脏病体外循环术中的应用 [J].新乡医学院学报,2012,29(10):762.
[7]周子凡１,万居易２,李殿坤１,等. 老年先天性心脏病并发重度肺动脉高压外科手术治疗与保守治疗临床效果比较[J].新乡医学院学报,2015,32(08):774.
[8]张新科,李保林.不同浓度七氟烷全程吸入对行先天性心脏病矫治术患儿心肌的影响[J].新乡医学院学报,2019,36(7):629.[doi:10.7683/xxyxyxb.2019.07.007]
　ZHANG Xin-ke,LI Bao-lin.Effect of different concentrations of sevoflurane inhalation on myocardial of children underwent congenital heart disease rectification operation[J].Journal of Xinxiang Medical University,2019,36(12):629.[doi:10.7683/xxyxyxb.2019.07.007]
[9]王志斌,樊开凯,乔晨晖.血浆白细胞介素-18、硫化氢水平对先天性心脏病患儿术后并发急性肺损伤的诊断价值[J].新乡医学院学报,2021,38(4):353.[doi:10.7683/xxyxyxb.2021.04.012]
　WANG Zhibin,FAN Kaikai,QIAO Chenhui.Diagnostic value of plasma interleukin-18 and hydrogen sulfide levels for postoperative acute lung injury in children with congenital heart disease[J].Journal of Xinxiang Medical University,2021,38(12):353.[doi:10.7683/xxyxyxb.2021.04.012]
[10]王鹏高,崔亚洲,陈忠建,等.大动脉调转术治疗婴儿大动脉转位近期疗效观察[J].新乡医学院学报,2020,37(8):729.[doi:10.7683/xxyxyxb.2020.08.006]
　WANG Penggao,CUI Yazhou,CHEN Zhongjian,et al.Short-term effect of arterial switch operation in the treatment of transposition of great arteries in infants[J].Journal of Xinxiang Medical University,2020,37(12):729.[doi:10.7683/xxyxyxb.2020.08.006]

更新日期/Last Update: 2018-12-05