[1]朱俊敬,郭素芹.首发儿童精神分裂症患者病前行为特征与病后认知功能的关系[J].新乡医学院学报,2018,35(11):1005-1008.[doi:10.7683/xxyxyxb.2018.11.015]
　ZHU Jun-jing,GUO Su-qin.Relationship between premorbid behavioral characteristics and cognitive function after onset in first-episode children with schizophrenia[J].Journal of Xinxiang Medical University,2018,35(11):1005-1008.[doi:10.7683/xxyxyxb.2018.11.015]
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首发儿童精神分裂症患者病前行为特征与病后认知功能的关系
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年11
页码:
1005-1008
栏目:
临床研究
出版日期:
2018-11-05

文章信息/Info

Title:
Relationship between premorbid behavioral characteristics and cognitive function after onset in first-episode children with schizophrenia
作者:
朱俊敬1; 郭素芹2
（1.郑州市第八人民医院儿童青少年心理科，河南　郑州　450006；2.新乡医学院第二附属医院儿童少年精神科，河南　新乡　453002）
Author(s):
ZHU Jun-jing1; GUO Su-qin2
（1.Department of Child and Adolescent Psychology，the Eighth People′s Hospital of Zhengzhou City，Zhengzhou 450006，Henan Province，China；2.Department of Child and Adolescent Psychiatry，the Second Affiliated Hospital of Xinxiang Medical University，Xinxiang 453002，Henan Province，China）
关键词:
精神分裂症; 儿童; Achenbach儿童行为量表; 认知功能
Keywords:
schizophrenia; children; child behavior check-list; cognitive function
分类号:
R749.3
DOI:
10.7683/xxyxyxb.2018.11.015
文献标志码:
A
摘要:
目的　探讨首发儿童精神分裂症患者病前行为特征与病后认知功能的关系。方法　选择2015年1月至2016年6月郑州市第八人民医院收治的66例首发儿童精神分裂症患者作为观察组，另选择70名正常儿童作为对照组。采用Achenbach儿童行为量表（CBCL）评估所有受试者6～11岁的行为特征，用事件相关电位P300及探究性眼动分析（EEM）评估所有受试者的认知功能。结果　观察组患者社会能力总分及学校情况因子得分均低于对照组，行为问题总分、社交退缩、分裂强迫及攻击因子得分均高于对照组（P<0.05）。观察组患者P300潜伏期高于对照组，波幅低于对照组（P<0.01）；观察组患者凝视点数（NEF）及反应性探索评分（RSS）低于对照组，D值高于对照组（P<0.01）。P300潜伏期与社会能力总分呈负相关（r=-0.257，P<0.05），与行为问题总分呈正相关（r=0.244，P<0.05）；P300波幅与社交能力因子得分呈正相关（r=0.205，P<0.05），与体诉因子得分呈负相关（r=-0.231，P<0.05）。NEF与行为问题总分呈负相关（r=-0.227，P<0.05），RSS与违纪及攻击因子得分均呈负相关（r=-0.340、-0.304，P<0.05）。结论　首发儿童精神分裂症患者病前行为特征与病后认知功能存在相关关系，病前社会能力越低、行为问题越多，病后认知功能损害越严重。
Abstract:
Objective　To explore the relationship between premorbid behavioral characteristics and cognitive function after onset in first-episode children with schizophrenia.Methods　Sixty-six children with first-episode schizophrenia in the Eighth Hospital of Zhengzhou City from January 2015 to June 2016 were selected as observation group and 70 healthy children were selected as control group.The behavioral characteristics of all subjects at the age of 6 to 11 years was assessed by achenbach child behavior checklist （CBCL）.The cognitive function of all subjects were assessed by event-related potentials（ERP） P300 and exploratory eye movement（EEM）.Results　The total score of social competence and school situation factor scores of patients in the observation group were significantly lower than those in the control group（P<0.05）；the total score of behavioral problem，social withdrawal factor，splitting force and attacking factor scores of patients in the observation group were significantly higher than those in the control group（P<0.05）.The latency of P300 of patients in the observation group was significantly higher than that in the control group，and the amplitude of P300 was significantly lower than that in the control group （P<0.01）.The number of eye fixations （NEF） and responsive search score （RSS） of patients in the observation group were significantly lower than those in the control group，and the D value of patients in the observation group was significantly higher than that in the control group （P<0.01）.The latency of P300 was negatively correlated with the total score of social competence （r=-0.257，P<0.05），and it was positively correlated with the total score of behavioral problems （r=0.244，P<0.05）.The amplitude of P300 was positively correlated with the sociability factor score （r=0.205，P<0.05），but it was negatively correlated with the physical complaints factor score （r=-0.231，P<0.05）.The NEF was negatively correlated with the total score of behavioral problems （r=-0.227，P<0.05），and the RSS was negatively correlated with the scores of discipline violation and aggressive factors （r=-0.340，-0.304；P<0.05）.Conclusion　There is a correlation between premorbid behavioral characteristics and cognitive function after onset in first-episode children with schizophrenia.The lower premorbid social ability and more behavioral problems，the more serious cognitive impairment after onset.

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更新日期/Last Update: 2018-11-05