[1]信　军,康　乐,张艺森,等.重组人促红细胞生成素对早产儿脑损伤的防治作用[J].新乡医学院学报,2018,35(10):928-930.[doi:10.7683/xxyxyxb.2018.10.020]
　XIN Jun,KANG Le,ZHANG Yi-sen,et al.Preventive effect of recombinant human erythropoietin on brain injury in premature infants[J].Journal of Xinxiang Medical University,2018,35(10):928-930.[doi:10.7683/xxyxyxb.2018.10.020]
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重组人促红细胞生成素对早产儿脑损伤的防治作用
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年10
页码:
928-930
栏目:
临床研究
出版日期:
2018-10-05

文章信息/Info

Title:
Preventive effect of recombinant human erythropoietin on brain injury in premature infants
作者:
信　军; 康　乐; 张艺森; 张　剑; 时英才
（驻马店市中心医院新生儿科，河南　驻马店　463000）
Author(s):
XIN Jun; KANG Le; ZHANG Yi-sen; ZHANG Jian; SHI Ying-cai
（Department of Neonatology，Zhumadian Central Hospital，Zhumadian 463000，Henan Province，China）
关键词:
重组人促红细胞生成素; 早产儿; 脑损伤; S100β; 白细胞介素-6
Keywords:
recombinant human erythropoietin; premature infant; brain injury; S100β; interleukin-6
分类号:
R722
DOI:
10.7683/xxyxyxb.2018.10.020
文献标志码:
A
摘要:
目的　探讨重组人促红细胞生成素（rhEPO）对早产儿脑损伤的防治作用。方法　选择2015年1月至2016年12月驻马店市中心医院收治的早产儿72例为研究对象。根据早产儿家属意愿及治疗方法分为观察组和对照组，每组36例。对照组早产儿给予保暖、维持血糖和血压、营养支持等常规治疗措施，观察组早产儿在常规治疗基础上给予rhEPO 250 IU·kg-1，静脉注射，每周3次，4周为1个疗程，共治疗3个疗程。分别于纠正胎龄40周（治疗前）及治疗后采用酶联免疫吸附试验法检测2组早产儿血清S100β、白细胞介素-6（IL-6）和促红细胞生成素（EPO）水平，2组早产儿分别于治疗前及治疗后采用新生儿行为神经测定（NBNA）评分法进行神经行为测试，并观察治疗期间2组早产儿并发症发生情况。结果　治疗前2组早产儿血清S100β、IL-6及EPO水平比较差异无统计学意义（P>0.05）；2组早产儿治疗后血清S100β及IL-6水平显著低于治疗前（P<0.05），EPO水平显著高于治疗前（P<0.05）；治疗后，观察组早产儿血清S100β及IL-6水平显著低于对照组（P<0.05），EPO水平显著高于对照组（P<0.05）。治疗前2组早产儿NBNA评分比较差异无统计学意义（P>0.05），2组早产儿治疗后NBNA评分显著高于治疗前（P<0.05）；治疗后，观察组早产儿NBNA评分显著高于对照组（P<0.05）。对照组和观察组早产儿并发症发生率分别为36.11%（13/36）和13.89%（5/36），观察组早产儿并发症发生率显著低于对照组（χ2=4.741，P<0.05）。结论　rhEPO预防性应用可以有效改善早产儿神经系统功能，减轻脑损伤。
Abstract:
Objective　To investigate the preventive effect of recombinant human erythropoietin（rhEPO） on brain injury in premature infants.Methods　A total of 72 premature infants in Zhumadian Central Hospital from January 2015 to December 2016 were selected as the subjects.The premature infants were divided into observation group and control group according to their parental wishes and treatment methods，36 cases in each group.The premature infants in the control group were treated with conventional treatment measures such as keeping warm，maintaining blood sugar and blood pressure，nutritional support and so on.The preterm infants in the observation group were treated with rhEPO 250 IU·kg-1 by intravenous injection for three courses of treatment，three times a week，and four weeks as a course of treatment.The levels of serum S100β，interleukin-6（IL-6） and erythropoietin（EPO） were detected by enzyme-linked immunosorbent assay at 40 weeks of corrected gestational age (before treatment) and after treatment.The neurobehavioral status of the preterm infants was assessed by neonatal behavioral neurological assessment（NBNA） score at before and after treatment.The complications of the preterm infants in the two groups were observed during treatment.Results　There was no significant difference in serum S100β，IL-6 and EPO levels between the two groups before treatment（P>0.05）.The levels of serum S100β and IL-6 of the preterm infants after treatment were significantly lower than those before treatment in the two groups（P<0.05），and the serum EPO level of the preterm infants after treatment was significantly higher than that before treatment in the two groups（P<0.05）.After treatment，the levels of serum S100β and IL-6 in the observation group were significantly lower than those in the control group（P<0.05），and the level of serum EPO in the observation group was significantly higher than that in the control group（P<0.05）.There was no significant difference in the NBNA score between the two groups before treatment（P>0.05）.The NBNA score of the preterm infants after treatment was significantly higher than that before treatment in the two groups（P<0.05）.The NBNA score of the premature infants in the observation group was significantly higher than that in the control group after treatment（P<0.05）.The incidence of complications in the control group and the observation group was 36.11%（13/36） and 13.89%（5/36） respectively，the incidence of complications in the observation group was significantly lower than that in the control group（χ2=4.741，P<0.05）.Conclusion　RhEPO prophylactic application can effectively improve neurological function and reduce brain damage in premature infants.

参考文献/References:

［1］　单继艳，卢红艳，张强，等.不同剂量rhEPO静注治疗早产儿脑损伤对比观察［J］.山东医药，2016，56（15）：59-61.
［2］　程力平，张群威，高小玲，等.血清Toll 样受体4 和肿瘤坏死因子-α水平与早产儿脑损伤的关系［J］.新乡医学院学报，2017，34（1）：50-52．
［3］　吴秀双，史源.基于多模态数据的早产儿脑功能发育监测及脑损伤诊断的应用前景［J］.中华实用儿科临床杂志，2017，32（14）：1055-1057.
［4］　董海鹏，宋燕燕，谭美珍，等.重组人促红细胞生成素对早产儿脑损伤保护作用的分析［J］.中国妇幼健康研究，2016，27（5）：568-570，576.
［5］　卢红艳，张强，常明，等.脐血及羊水生物学标志预测胎膜早破早产儿脑损伤的价值［J］.中华实用儿科临床杂志，2016，31（6）：452-456.
［6］　尚云，马慧敏，郭喜霞，等.促红细胞生成素对宫内感染致脑损伤早产新生大鼠神经胶质酸性蛋白和S-100β表达的影响［J］.中国儿童保健杂志，2014，22（10）：1047-1050.
［7］　KOBAYASHI S，WAKUSAWA K，INUI T，et al.The neurological outcomes of cerebellar injury in premature infants［J］.Brain Dev，2015，37（9）：858-863.
［8］　黄平，王振原，托娅.神经生化标志物S100β蛋白研究进展［J］.法医学杂志，2005，21（2）：149-151.
［9］　陈光福，李辉桃，黄进洁，等.早产儿血清促红细胞生成素水平与脑损伤的关系［J］.中国当代儿科杂志，2016，18（10）：947-952.
［10］　金越，陆继红，鲍星星，等.尿S-100β蛋白动态变化对早产儿脑损伤的诊断价值［J］.临床儿科杂志，2015，33（1）：44-47.
［11］　吴馥鸾，陈蓉，殷杰.促红细胞生成素对缺氧缺血性脑损伤新生大鼠海马组织整合素β1表达的影响［J］.中华实用儿科临床杂志，2017，32（12）：908-911.
［12］　宋朝敏，王程毅，杨斌，等.外源性重组人促红细胞生成素对高氧脑损伤新生大鼠模型神经细胞凋亡及5-脂氧酶的影响［J］.中华实用儿科临床杂志，2017，32（6）：461-464.
［13］　曾庆煌，曾仁和.重组人促红细胞生成素联合外源性单唾液酸四己糖神经节苷脂治疗重度新生儿缺氧缺血性脑病的疗效［J］.中华实用儿科临床杂志，2016，31（20）：1582-1583.

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更新日期/Last Update: 2018-10-05