[1]许　洁,安　珍,何　舰.白细胞免疫球蛋白样受体亚家族B生物学功能研究进展[J].新乡医学院学报,2018,35(9):835-839.[doi:10.7683/xxyxyxb.2018.09.021]
　N/A.N/A[J].Journal of Xinxiang Medical University,2018,35(9):835-839.[doi:10.7683/xxyxyxb.2018.09.021]
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白细胞免疫球蛋白样受体亚家族B生物学功能研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年9
页码:
835-839
栏目:
综述
出版日期:
2018-09-05

文章信息/Info

Title:
N/A
作者:
许　洁1; 安　珍1; 何　舰2
（1.新乡医学院公共卫生学院，河南　新乡　453003；2.上海市同济医院　同济大学附属同济医院病理科，上海　200065）
Author(s):
N/A
N/A
关键词:
白细胞免疫球蛋白样受体亚家族B; 配体; 生物学功能
Keywords:
N/A
分类号:
R593.22
DOI:
10.7683/xxyxyxb.2018.09.021
文献标志码:
A
摘要:
白细胞免疫球蛋白样受体亚家族B（LILRB）属于I型跨膜糖蛋白，为免疫抑制性受体。目前，已知的LILRBs受体包括5种类型，分别为LILRB1、2、3、4、5。LILRBs在免疫细胞、破骨细胞、神经细胞和肿瘤细胞等多种细胞广泛表达，并能够识别多种配体。LILRBs具有调节炎症反应、免疫耐受、细胞分化和神经系统的可塑性等多种生物学功能，并在炎症性疾病、自身免疫性疾病、传染性疾病、神经系统疾病和恶性肿瘤等多种疾病中发挥重要作用。本文就最近发现的LILRBs的表达部位、配体、生物学功能及其在相关疾病中的研究进展进行综述。
Abstract:
N/A

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更新日期/Last Update: 2018-09-05