«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:

35

期数:

2018年5

页码:

425-427

栏目:

临床研究

出版日期:

2018-05-05

文章信息/Info

Title:

Effect of hemocoagulase combined with omeprazole sodium injection in the treatment of elderly patients with peptic ulcer hemorrhage

作者:

张　川¹; 2; 谢明容³; 穆学伟⁴

（1.雅安职业技术学院附属医院急诊科，四川　雅安　625000；2.雅安市人民医院内科，四川　雅安　625000；3.雅安市人民医院消化内科，四川　雅安　625000；4.雅安市人民医院急诊科，四川　雅安　625000）

Author(s):

ZHANG Chuan¹; 2; XIE Ming-rong³; MU Xue-wei⁴

（1.Department of Emergency，the Affiliated Hospital of Ya′an Polytechnic College，Ya′an 625000，Sichuan Province，China；2.Department of Internal Medicine，Ya′an People′s Hospital，Ya′an 625000，Sichuan Province，China；3.Department of Gastroenterology，Ya′an People′s Hospital，Ya′an 625000，Sichuan Province，China；4.Department of Emergency，Ya′an People′s Hospital，Ya′an People′s Hospital，Ya′an 625000，Sichuan Province，China）

关键词:

消化性溃疡出血; 血凝酶; 奥美拉唑钠注射液; 止血效果

Keywords:

peptic ulcer hemorrhage; hemocoagulase; omeprazole sodium injection; hemostatic effect

分类号:

R573.1

DOI:

10.7683/xxyxyxb.2018.05.018

文献标志码:

A

摘要:

目的　探讨血凝酶联合奥美拉唑钠注射液治疗老年消化性溃疡出血的临床效果。方法　选择2016年1月至2017年9月雅安职业技术学院附属医院收治的消化性溃疡出血老年患者70例，根据治疗方法将患者分为观察组和对照组，每组35例。2组患者均给予补充血容量、纠正电解质紊乱、营养支持等常规治疗，在常规治疗的基础上，对照组患者给予奥美拉唑钠注射液治疗，观察组患者给予奥美拉唑钠注射液和血凝酶联合治疗，对2组患者的治疗效果进行比较。结果　观察组患者出血量和输血量显著少于对照组，止血时间和住院时间显著短于对照组（P<0.05）。治疗前2组患者血清中血管内皮生长因子（VEGF）、表皮生长因子（EGF）及超氧化物歧化酶（SOD）水平比较差异均无统计学意义（P>0.05）；2组患者治疗后血清中VEGF、EGF及SOD水平显著高于治疗前（P<0.05）；治疗后，观察组患者血清中EGF、VEGF及SOD水平显著高于对照组（P<0.05）。观察组和对照组患者治疗总有效率分别为94.29%（33/35）、74.29%（26/35），观察组患者治疗总有效率显著高于对照组（χ²=5.285，P<0.05）。结论　血凝酶联合奥美拉唑钠注射液治疗老年消化性溃疡出血患者具有更好的止血效果，且可以促进溃疡愈合，提高治疗效果。

Abstract:

Objective　To investigate the effect of hemocoagulase combined with omeprazole sodium injection in the treatment of elderly patients with peptic ulcer hemorrhage.Methods　A total of 70 elderly patients with peptic ulcer hemorrhage were selected from January 2016 to September 2017 in the Affiliated Hospital of Ya′an Polytechnic College.The patients were divided into observation group and control group according to therapeutic method，with 35 patients in each group.The patients in the two groups were treated with routine treatment such as supplemental blood volume，correction of electrolyte disturbance，nutritional support，and so on.On the basis of routine treatment，the patients in the control group were treated with omeprazole sodium injection，and the patients in the observation group were treated with omeprazole sodium injection combined with hemocoagulase.The effect was compared between the two groups.Results　The amount of bleeding and blood transfusion in the observation group were significantly less than those in the control group，and the hemostatic time and hospitalization time were significantly shorter than those in the control group （P<0.05）.There was no significant difference in the levels of serum vascular endothelial growth factor （VEGF），epidermal growth factor （EGF） and superoxide dismutase （SOD） between the two groups before treatment （P>0.05）.The levels of serum VEGF，EGF and SOD after treatment were significantly higher than those before treatment in the two groups （P<0.05）.The levels of serum EGF，VEGF and SOD in the observation group were significantly higher than those in the control group after treatment （P<0.05）.The total effective rate in the observation group and the control group was 94.29% （33/35） and 74.29% （26/35） respectively，and the total effective rate in the observation group was significantly higher than that in the control group （χ²=5.285，P<0.05）.Conclusion　Hemocoagulase combined with omeprazole sodium injection has better hemostatic effect in elderly patients with peptic ulcer hemorrhage，and can promote ulcer healing and improve therapeutic effect.

常用功能

更新日期/Last Update: 2018-05-05