[1]郭璐映,刘　儒,张保朝.单纯舒张期高血压患者舒张压峰值与颈动脉粥样硬化的相关性[J].新乡医学院学报,2018,35(4):320-322.[doi:10.7683/xxyxyxb.2018.04.016]
　GUO Lu-ying,LIU Ru,ZHANG Bao-chao.Correlation between the peak value of diastolic blood pressure and carotid atherosclerosis in patients with isolated diastolic hypertension[J].Journal of Xinxiang Medical University,2018,35(4):320-322.[doi:10.7683/xxyxyxb.2018.04.016]
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单纯舒张期高血压患者舒张压峰值与颈动脉粥样硬化的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年4
页码:
320-322
栏目:
临床研究
出版日期:
2018-04-05

文章信息/Info

Title:
Correlation between the peak value of diastolic blood pressure and carotid atherosclerosis in patients with isolated diastolic hypertension
作者:
郭璐映1; 刘　儒1; 张保朝2
（1.南阳市中心医院心脏电生理科，河南　南阳　473000；2.南阳市中心医院神经内科，河南　南阳　473000）
Author(s):
GUO Lu-ying1; LIU Ru1; ZHANG Bao-chao2
（1.Department of Electrocardiogram，Nanyang Central Hospital，Nanyang 473000，Henan Province，China；2.Department of Neurology，Nanyang Central Hospital，Nanyang 473000，Henan Province，China）
关键词:
单纯舒张期高血压; 舒张压峰值; 颈动脉粥样硬化
Keywords:
isolated diastolic hypertension; diastolic peak; carotid atherosclerosis
分类号:
R544.1
DOI:
10.7683/xxyxyxb.2018.04.016
文献标志码:
A
摘要:
目的　探讨单纯舒张期高血压（IDH）患者舒张压峰值与颈动脉粥样硬化的相关性。方法　选择南阳市中心医院2011年6月至2017年6月收治的IDH患者200例为观察对象，按是否存在颈动脉粥样硬化分为IDH组（对照组）和IDH合并颈动脉粥样硬化组（观察组），每组100例。使用彩色超声诊断仪检测2组患者双侧颈动脉内膜中层厚度（IMT），采用动态血压监测仪检测2组患者舒张压峰值，并检测2组患者血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、丙氨酸氨基转移酶（ALT）和肌酐（CR）水平，分析舒张压峰值与实验室检测指标及IMT的相关性。结果　对照组患者舒张压峰值及IMT分别为（102.35±10.48）mmHg（1 mmHg=0.133 kPa）、（0.82±0.07）mm，观察组患者舒张压峰值及IMT分别为（115.27±10.44）mmHg、（1.31±0.09）mm，观察组患者舒张压峰值及IMT显著高于对照组（P<0.05）。与对照组比较，观察组患者血清TG、TC、LDL-C水平显著增高（P<0.05），ALT和CR水平显著降低（P<0.05）；2组患者血清FPG、HDL-C水平比较差异无统计学意义（P>0.05）。Spearman相关分析显示，IDH患者舒张压峰值与血清TC、LDL-C水平及IMT呈显著正相关（r=0.755、0.286、0.127，P<0.05），而与血清TG、HDL-C、FPG、ALT、CR水平无显著相关性（r=-0.207、-0.010、-0.046、-0.038、-0.024，P>0.05）。结论　IDH患者舒张压峰值与颈动脉粥样硬化的发生有一定相关性，舒张压峰值越高，形成颈动脉粥样硬化的风险越高。
Abstract:
Objective　To investigate the correlation between the peak value of diastolic blood pressure and carotid atherosclerosis in patients with isolated diastolic hypertension（IDH）.Methods　A total of 200 patients with IDH treated in Nanyang Central Hospital from June 2011 to June 2017 were selected as the subjects.The patients were divided into IDH group（control group） and IDH combined with carotid atherosclerosis group（observation group） according to whether they had carotid atherosclerosis or not，100 cases in each group.The bilateral carotid artery intima-media thickness（IMT） was detected by color ultrasound diagnostic instrument，and the peak value of diastolic blood pressure was detected by ambulatory blood pressure monitor.The levels of serum total cholesterol（TC），three triglyceride（TG），high-density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C），fasting blood glucose（FPG），alanine aminotransferase（ALT） and creatinine（CR） were detected and compared in the two groups.The correlation between the peak value of diastolic blood pressure and the laboratory indexes and IMT was analyzed.Results　The peak value of diastolic blood pressure and the IMT in the control group were（102.35±10.48）mmHg(1 mmHg=0.133 kPa) and（0.82±0.07）mm respectively，and they were（115.27±10.44）mmHg and（1.31±0.09）mm，respectively in the observation group.The peak value of diastolic blood pressure and the IMT in the observation group were significantly higher than those in the control group（P<0.05）.The serum TG，TC and LDL-C levels of the patients in the observation group were significantly higher than those in the control group（P<0.05）；and the levels of serum ALT and CR in the observation group were significantly lower than those in the control group（P<0.05）；but there was no significant difference in serum FPG and HDL-C levels between the two groups（P>0.05）.Spearman correlation analysis showed that the peak value of diastolic blood pressure was significantly correlated with serum TC，LDL-C and IMT in IDH patients（r=0.755，0.286，0.127；P<0.05）；but there was no significant correlation between the peak value of diastolic blood pressure and the levels of serum TG，HDL-C,FPG,ALT and CR in IDH patients（r=-0.207，-0.010，-0.046,-0.038,-0.024；P>0.05）.Conclusion　There is a certain correlation between the peak value of diastolic blood pressure and the occurrence of carotid atherosclerosis in IDH patients.With the increasing of the peak value of diastolic blood pressure，the risk of carotid atherosclerosis is increased.

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更新日期/Last Update: 2018-04-05