[1]原瑞芳,王少青.难治性支原体肺炎患儿支气管肺泡灌洗液中表面活性物质相关蛋白-A表达与肺功能的关系[J].新乡医学院学报,2018,35(3):189-191.[doi:10.7683/xxyxyxb.2018.03.007]
　YUAN Rui-fang,WANG Shao-qing.Relationship between surfactant associated protein-A in bronchoalveolar lavage fluid and lung function in children with refractory mycoplasma pneumoniae pneumonia[J].Journal of Xinxiang Medical University,2018,35(3):189-191.[doi:10.7683/xxyxyxb.2018.03.007]
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难治性支原体肺炎患儿支气管肺泡灌洗液中表面活性物质相关蛋白-A表达与肺功能的关系
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年3
页码:
189-191
栏目:
临床研究
出版日期:
2018-03-05

文章信息/Info

Title:
Relationship between surfactant associated protein-A in bronchoalveolar lavage fluid and lung function in children with refractory mycoplasma pneumoniae pneumonia
作者:
原瑞芳; 王少青
（鹤壁市人民医院儿科，河南　鹤壁　458000）
Author(s):
YUAN Rui-fang; WANG Shao-qing
（Department of Pediatrics，the People′s Hospital of Hebi City，Hebi 458000，Henan Province，China）
关键词:
难治性支原体肺炎; 支气管肺泡灌洗液; 肺泡表面活性蛋白-A; 肺功能
Keywords:
refractory mycoplasma pneumoniae pneumonia; bronchoalveolar lavage fluid; surfactant associated protein-A; lung function
分类号:
R725.6
DOI:
10.7683/xxyxyxb.2018.03.007
文献标志码:
A
摘要:
目的　探讨难治性支原体肺炎（RMPP）患儿支气管肺泡灌洗液（BALF）中表面活性物质相关蛋白-A（SP-A）的表达与肺功能的相关性。方法　选择2015年1月至2016年12月鹤壁市人民医院收治的RMPP患儿30例，分别于急性期和恢复期检测患儿动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、第1秒用力呼气量（FEV1）和用力肺活量（FVC），并行支气管肺泡灌洗，收集BALF，采用酶联免疫吸附试验检测BALF中SP-A水平。结果　RMPP患儿急性期和恢复期BALF中SP-A水平分别为（3.63±0.09）、（5.86±0.17）mg·L-1，RMPP患儿急性期BALF中SP-A水平显著低于恢复期（t=-63.499，P<0.05）。RMPP患儿急性期PaO2和PaCO2分别为（49.25±7.32）、（47.16±6.48）mmHg，恢复期PaO2和PaCO2分别为（76.54±6.48）、（36.20±5.61）mmHg；RMPP患儿急性期PaO2显著低于恢复期（t=-15.289，P<0.05），急性期PaCO2显著高于恢复期（t=7.004，P<0.05）。RMPP患儿急性期FEV1、FVC和FEV1/FVC分别为（1.36±0.67）、（1.68±0.31）L和69.85±8.34，恢复期FEV1、FVC和FEV1/FVC分别为（1.89±0.58）、（1.99±0.53）L和87.32±9.52；RMPP患儿急性期FEV1、FVC和FEV1/FVC显著低于恢复期（t=-3.276、-2.765、-7.560，P<0.05）。RMPP患儿BALF中SP-A水平与PaO2呈正相关（r=0.921 6，P<0.05），与PaCO2无显著相关（r=1.211 4，P>0.05）；BALF中SP-A水平与FEV1、FVC和FEV1/FVC均呈正相关（r=0.831、0.905、0.803，P<0.05）。结论　RMPP患儿BALF中SP-A水平与呼吸功能呈正相关，检测患儿BALF中SP-A水平有助于评估患儿肺功能，判断患儿病情。
Abstract:
Objective　To investigate the relationship between surfactant associated protein-A（SP-A） in bronchoalveolar lavage fluid（BLAF） and lung function in children with refractory mycoplasma pneumoniae pneumonia（RMPP）.Methods　Thirty children with RMPP were selected from January 2015 to December 2016 in the People′s Hospital of Hebi City.The partial pressure of oxygen in artery（PaO2），partial pressure of carbon dioxide in artery（PaCO2），forced expiratory volume in one second（FEV1） and forced vital capacity（FVC） of the children were detected at acute and convalescent periods.The BALF was collected by bronchoalveolar lavage，and the level of SP-A in BALF was detected by enzyme linked immunosorbent assay.Results　The level of SP-A in BALF of children with RMPP at acute and convalescent period was（3.63±0.09） and （5.86±0.17）mg·L-1 respectively，the level of SP-A in BALF of children with RMPP at acute phase was significantly lower than that at convalescent period（t=-63.499，P<0.05）.The PaO2 and PaCO2 in children with RMPP at acute phase were （49.25±7.32） and （47.16±6.48）mmHg respectively，and they were （76.54±6.48） and （36.20± 5.61）mmHg respectively at convalescent period；the PaO2 in children with RMPP at acute phase was significantly lower than that at convalescent period（t=-15.289，P<0.05），and the PaO2 in children with RMPP at acute phase was significantly higher than that at convalescent period（t=7.004，P<0.05）.The FEV1，FVC and FEV1/FVC in RMPP children at acute phase were （1.36±0.67），（1.68±0.31）L and 69.85±8.34 respectively；and they were （1.89±0.58），（1.99±0.53）L and 87.32±9.52 respectively at convalescent period；the FEV1，FVC and FEV1/FVC in RMPP children at acute phase were significantly lower than those at convalescent period（t=-3.276，-2.765，-7.560；P<0.05）.The level of SP-A in BALF of children with RMPP was positively correlated with PaO2（r=0.921 6，P<0.05），but there was no significant correlation between SP-A level and PaCO2（r=1.211 4，P>0.05）.The level of SP-A in BALF was positively correlated with FEV1，FVC and FEV1/FVC（r=0.831，0.905，0.803；P<0.05）.Conclusion　The level of SP-A in BALF was positively correlated with lung function of children with RMPP.The detection of SP-A level in BALF is helpful to assess the lung function and pathogenetic condition of children with RMPP.

参考文献/References:

［1］　GUO W L，WANG J，ZHU L Y，et al.Differentiation between mycoplasma and viral community-acquired pneumonia in children with lobe or multi foci infiltration：a retrospective case study［J］.BMJ Open，2015，5（1）：e006766.
［2］　周红，徐庆雷，马小波，等.粒细胞巨噬细胞集落刺激因子、髓过氧化物酶在肺炎支原体肺炎患儿支气管肺泡灌洗液中的表达及其临床意义［J］.中华实用儿科临床杂志，2017，32（4）：313-315.
［3］　董琳.2岁以下儿童支原体肺炎临床特征分析［J］.新乡医学院学报，2017，34（6）：517-518.
［4］　温顺航，张海邻，李昌崇.儿童肺炎支原体肺炎的影像学表现［J］.中华实用儿科临床杂志，2016，31（16）：1272-1274.
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更新日期/Last Update: 2018-03-05