[1]梁长华,毛华杰,梁　盼,等.原发性肝癌320排容积CT灌注参数值与肿瘤体积及肝功能Child-Pugh分级的相关性[J].新乡医学院学报,2018,35(1):065-68.[doi:10.7683/xxyxyxb.2018.01.016]
　LIANG Chang-hua,MAO Hua-jie,LIANG Pan,et al.Correlation between 320 row volume CT perfusion parameters of primary liver cancer and liver tumor volume and liver function Child-Pugh classification[J].Journal of Xinxiang Medical University,2018,35(1):065-68.[doi:10.7683/xxyxyxb.2018.01.016]
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原发性肝癌320排容积CT灌注参数值与肿瘤体积及肝功能Child-Pugh分级的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年1
页码:
065-68
栏目:
临床研究
出版日期:
2018-01-05

文章信息/Info

Title:
Correlation between 320 row volume CT perfusion parameters of primary liver cancer and liver tumor volume and liver function Child-Pugh classification
作者:
梁长华1; 毛华杰1; 梁　盼2; 户彦龙1; 张会杰1; 王东东1; 高剑波2
（1.新乡医学院第一附属医院放射科，河南　卫辉　453100；2.郑州大学第一附属医院放射科，河南　郑州　450052）
Author(s):
LIANG Chang-hua1; MAO Hua-jie1; LIANG Pan2; HU Yan-long1; ZHANG Hui-jie1; WANG Dong-dong1; GAO Jian-bo2
（1.Department of Radiology，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province，China；2.Department of Radiology，the First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，Henan Province，China）
关键词:
原发性肝癌; 肝储备功能; Child-Pugh分级; 计算机体层摄影术; CT灌注成像
Keywords:
primary liver cancer; hepatic functional reserve; Child-Pugh classification; computed tomography; CT perfusion imaging
分类号:
R735.7
DOI:
10.7683/xxyxyxb.2018.01.016
文献标志码:
A
摘要:
目的　探讨原发性肝癌320排容积CT全肿瘤灌注参数值与肿瘤体积、瘤周肝组织灌注参数值的关系，并分析其与肝脏Child-Pugh分级的相关性。方法　选择2013年1月至2015年1月于郑州大学第一附属医院行320排容积CT灌注成像的原发性肝癌患者47例，根据全肿瘤测量法计算肿瘤体积及瘤体、瘤周肝组织的肝动脉灌注量（HAP）、门静脉灌注量（PVP）及肝动脉灌注指数（HAPI），分析瘤体各灌注参数值与肿瘤体积及肝功能Child-Pugh分级的关系。结果　肿瘤体积与全肿瘤灌注参数值、瘤周灌注参数值无相关性（P>0.05），全肿瘤灌注参数值与瘤周灌注参数值无相关性（P>0.05）。不同肝功能Child-Pugh分级患者的全肿瘤灌注参数值HAP、PVP及HAPI比较差异有统计学意义（P<0.05）。随着肝功能Child-Pugh分级的增加，瘤体HAP及HAPI逐渐增加，而PVP逐渐减小（P<0.05）。结论　原发性肝癌瘤体体积与全肿瘤灌注参数值、瘤周灌注参数值无相关性，全肿瘤灌注参数值与瘤周灌注参数值无相关性；不同肝脏Child-Pugh分级间的各灌注参数值存在差异，全肿瘤测量法获得的灌注参数值可作为反应肝脏储备功能的影像学指标。
Abstract:
Objective　To explore the relationship between the values of total tumor perfusion parameters in primary hepatocellular carcinoma and tumor volume and peritumoral perfusion parameters，and analyze its correlation with liver Child-Pugh classification.Methods　Forty-seven patients with primary liver cancer in the First Affiliated Hospital of Zhengzhou University from January 2013 to January 2015 were selected to perform 320 row volume CT perfusion imaging.The parameters of hepatic artery perfusion（HAP），portal vein perfusion（PVP） and hepatic perfusion index（HAPI） in tumor and peritumoral liver tissues were calculated based on total tumor measurement.The relationship between tumor perfusion parameters and Child-Pugh classification of liver function，tumor volume and total tumor perfusion parameters，total tumor perfusion parameters and peritumoral perfusion parameters were analyzed.Results　There was no correlation between tumor volume and total tumor perfusion parameters,peritumoral perfusion parameters （P>0.05）,and there was no correlation between total tumor perfusion parameters and peritumoral perfusion parameters(P>0.05).There were significant differences between HAP，PVP and HAP of total tumor perfusion in different liver Child-Pugh classifications（P<0.05）.With the increase of Child-Pugh classification of liver function，the HAP and HAPI of tumor gradually increased while PVP gradually decreased(P<0.05).Conclusion　There is no correlation between tumor volume，total tumor perfusion parameters and peritumoral perfusion parameters.There is also no correlation between total tumor perfusion parameters and peritumoral perfusion parameters.There are significant differences in perfusion parameters between different Child-Pugh classifications of liver function，and the perfusion parameters obtained by the total tumor measurement can be used as the imaging indexes to reflect liver reserve function.

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更新日期/Last Update: 2018-01-05