[1]张惠娟,赵学科,宋　昕,等.食管鳞状细胞癌组织中PLCE1蛋白表达与患者生存的关系[J].新乡医学院学报,2017,34(12):1068-1072.[doi:10.7683/xxyxyxb.2017.12.006]
　ZHANG Hui-juan,ZHAO Xue-ke,SONG Xin,et al.Expression of PLCE1 in esophageal squamous cell carcinoma tissues and survival analysis[J].Journal of Xinxiang Medical University,2017,34(12):1068-1072.[doi:10.7683/xxyxyxb.2017.12.006]
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食管鳞状细胞癌组织中PLCE1蛋白表达与患者生存的关系
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年12
页码:
1068-1072
栏目:
临床研究
出版日期:
2017-12-05

文章信息/Info

Title:
Expression of PLCE1 in esophageal squamous cell carcinoma tissues and survival analysis
作者:
张惠娟1; 2; 赵学科2; 宋　昕2; 张　朋2; 吕　双2; 王　琛3; 王立东2
（1.郑州市第七人民医院体检中心，河南　郑州　450016；2.郑州大学第一附属医院河南省食管癌重点开放实验室，河南　郑州　450052；3.郑州大学公共卫生学院流行病与卫生统计学教研室，河南　郑州　450001）
Author(s):
ZHANG Hui-juan1; 2; ZHAO Xue-ke2; SONG Xin2; ZHANG Peng2; LYU Shuang2; WANG Chen3; WANG Li-dong2
（1.Medical Examination Center，the Seventh People′s Hospital of Zhengzhou，Zhengzhou 450016，Henan Province，China；2.Henan Key Laboratory for Esophageal Cancer Research，the First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，Henan Province，China；3.Department of Epidemiology and Statistics，College of Public Health，Zhengzhou University，Zhengzhou 450001，Henan Province，China）
关键词:
食管鳞状细胞癌; PLCE1; 生存分析
Keywords:
esophageal squamous cell carcinoma; PLCE1; survival analysis
分类号:
R735.1
DOI:
10.7683/xxyxyxb.2017.12.006
文献标志码:
A
摘要:
目的　观察食管鳞状细胞癌（ESCC）组织中PLCE1蛋白表达变化，探讨其表达与食管癌患者预后的关系。方法　收集河南省食管癌重点开放实验室资料库1997年3月至2011年12月手术切除的85例ESCC患者组织标本，对标本进行PLCE1免疫组织化学染色，采用Kaplan-Meier单因素与Cox多元回归进行生存分析。结果　85例ESCC患者中，失访5例，随访率为94.1%（80/85）。80例ESCC标本中PLCE1阳性表达率为77.5%（62/80）。PLCE1阳性表达与ESCC分化程度、浸润深度、淋巴结转移及家族史无显著相关性（P>0.05）。Kaplan-Meier法生存分析结果显示，PLCE1阳性表达与ESCC患者生存率无显著相关性（P>0.05）。Cox回归分析结果显示，淋巴结转移与ESCC患者的生存时间相关（相对危险度为1.763，95%可信区间：下限为1.008，上限为3.084，P=0.047）。结论　PLCE1蛋白表达参与食管癌变机制，但不能预测ESCC患者预后。
Abstract:
Objective　To investigate PLCE1 protein expression in esophageal squamous cell carcinoma （ESCC）tissues，and understand the effect of PLCE1 protein expression on the prognosis of patients with ESCC.Methods　The PLCE1 protein were detected in 85 patients with surgically resected ESCC paraffin-embedded tissue using immunohistochemical staining，the patients′ information were selected from March 1997 to December 2011 in the database of the Henan Key Laboratory for Esophageal Cancer Research，and the survival analysis were operated with Kaplan Meier single factor and Cox multivariate regression.Results　In the 85 cases，the lost to follow-up were 5 cases，the follow-up rate was 94.1% （80/85）.In the 80 cases with ESCC，the positive expression rate of PLCE1 was 77.5% （62/80）.PLCE1 positive expression was not significantly associated with differentiation，infiltration depth，lymph node metastasis and family history with ESCC（P>0.05）.The univariate survival analysis by Kaplan-Meier showed that protein expression of PLCE1 had no significant association with overall survival（P>0.05）.Cox regression survival analysis showed that the lymph node metastasis was associated with the survival time of ESCC patients［the relative risk were 1.763，95%CI（1.008，3.084），P=0.047］.Conclusion　The expression of PLCE1 protein was involved in mechanism of ESCC，and might not predicted the prognosis of the patients with ESCC.

参考文献/References:

［1］　CHEN W，ZHENG R，BAADE P D，et al.Cancer statistics in China，2015［J］.CA Cancer J Clin，2016，66（2）：115-132.
［2］　鲍启德，张长江，刘敏，等.食管癌临床症状类型及其年龄和性别分布特征［J］.新乡医学院学报，2017，34（7）：570-573，578.
［3］　CHEUNG W Y，LIU G.Genetic variations in esophageal cancer risk and prognosis［J］.Gastroenterol Clin North Am，2009，38（1）：75-80.
［4］　王立东，宋昕，赵学科，等.食管癌环境和遗传危险因素交互作用的分子基础和精准预防［J］.中国肿瘤临床，2016，43（12）：515-520.
［5］　WANG L D，ZHOU F Y，LI X M，et al.Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54［J］.Nat Genet，2010，42（9）：759-763.
［6］　BUNNEY T D，KATAN M.Phosphoinositide signalling in cancer：Beyond PI3K and PTEN［J］.Nat Rev Cancer，2010，10：342-352.
［7］　CUI X B，PENG H，LI S，et al.Prognostic value of PLCE1 expression in upper gastrointestinal cancer：a systematic review and meta-analysis［J］.Asian Pac J Cancer Prev，2014，15 （22）：9661-9666.
［8］　赵学科，周福有，张连群，等.食管癌变过程中PLCE1蛋白的表达［J］.河南大学学报（医学版），2012，31（3）：203-205.
［9］　朱佳龙，尹来波，侯量，等.PLCE1 蛋白在新疆哈萨克族食管鳞癌中的表达及意义［J］.农垦医学，2012，34（1）：5-8.
［10］　张晓娟，石劲松，张玲染，等.食管鳞状细胞癌组织中PLCE1和RFT2的表达及临床意义［J］.临床与实验病理学杂志，2015，31（12）：1348-1351.
［11］　WANG L D，HONG J Y，QIU S L，et al.Accumulation of p53 protein in human esophageal precancerous lesions：a possible early biomarker for carcinogenesis［J］.Cancer Res，1993，53（8）：1783-1787.
［12］　SONG C，HU C D，MASAGO M，et al.Regulation of a novel human phospholipase C，PLC epsilon，through membrane targeting by Ras［J］.J Biol Chem，2001，276（4）：2752-2757.
［13］　HU H，YANG J，SUN Y，et al.Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma （ESCC）：a case-control study in eastern Chinese populations［J］.Ann Surg Oncol，2012，19（7）：2403-2410.
［14］　WANG L D，BI X，SONG X，et al.A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis［J］.Mol Carcinog，2013，52（Suppl 1）：E80-E86.
［15］　李昀，张军航，安军，等.PLCE1调控p53诱导食管癌细胞凋亡的实验研究［J］.中国药理学通报，2015，31（1）：82-86.
［16］　LI W Q，HU N，BURTON V H，et al.PLCE1 mRNA and protein expression and survival of patients with esophageal squamous cell carcinoma and gastric adenocarcinoma［J］.Cancer Epidemiol Biomarkers Prev，2014，23（8）：1579-1588.
［17］　UMAR M，UPADHYAY R，KUMAR S，et al.Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population［J］.Tumour Biol，2014，35（11）：11667-11676.
［18］　QU Y，ZHANG S，CUI L，et al.Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population［J］.Dis Esophagus，2017，30（1）：1-7.
［19］　LIN Y，TOTSUKA Y，SHAN B，et al.Esophageal cancer in high-risk areas of China：research progress and challenges［J］.Ann Epidemiol，2017，27（3）：215-221.

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更新日期/Last Update: 2017-12-05