[1]徐鹏卫,代克强,卢建国,等.流行性感冒防控新策略研究进展[J].新乡医学院学报,2017,34(11):955-959.[doi:10.7683/xxyxyxb.2017.11.001]
点击复制

流行性感冒防控新策略研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年11
页码:
955-959
栏目:
专家论坛
出版日期:
2017-11-05

文章信息/Info

作者:
徐鹏卫1代克强2卢建国3吴卫东1
(1.新乡医学院公共卫生学院,河南 新乡 453003;2.新乡医学院第一临床学院,河南 卫辉 453100;3.新乡医学院第一附属医院胸外二科,河南 卫辉 453100)
关键词:
流行性感冒病毒疫苗抗病毒药物防控策略
分类号:
R183.3
DOI:
10.7683/xxyxyxb.2017.11.001
文献标志码:
A
摘要:
流行性感冒是由流行性感冒病毒引起的可造成大规模流行的急性呼吸道传染病,具有较高的发病率和致死率,是长期以来威胁人类健康的主要传染病之一。当前的疫苗、抗病毒药物可用于控制流行性感冒,但均存在一定的局限性和弊端,如流行性感冒疫苗的保护能力有限,且每年均需随病毒的变异而更新;抗病毒药物可能导致快速而广泛的耐药性产生。因此,研究更为安全、高效的流行性感冒防控手段仍是当前的科研热点之一,本文针对以病毒或宿主细胞为靶点的抗流行性感冒新策略进行了综述。

参考文献/References:

[1] COX N J,SUBBARAO K.Global epidemiology of influenza:past and present[J].Annu Rev Med,2000,51:407-421.
[2] GAMBLIN S J,SKEHEL J J.Influenza hemagglutinin and neuraminidase membrane glycoproteins[J].J Biol Chem,2010,285(37):28403-28409.
[3] ESTE J A,TELENTI A.HIV entry inhibitors[J].Lancet,2007,370(9581):81-88.
[4] HU J,ROBINSON J L.Treatment of respiratory syncytial virus with palivizumab:a systematic review[J].World J Pediatr,2010,6(4):296-300.
[5] MATTHEWS T,SALGO M,GREENBERG M,et al.Enfuvirtide:the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes[J].Nat Rev Drug Discov,2004,3(3):215-225.
[6] EKIERT D C,KASHYAP A K,STEEL J,et al.Cross-neutralization of influenza A viruses mediated by a single antibody loop[J].Nature,2012,489(7417):526-532.
[7] YOSHIDA R,IGARASHI M,OZAKI H,et al.Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses[J].PLoS Pathog,2009,5(3):e1000350.
[8] JONES J C,TURPIN E A,BULTMANN H,et al.Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells[J].J Virol,2006,80(24):11960-11967.
[9] NICOL M Q,LIGERTWOOD Y,BACON M N,et al.A novel family of peptides with potent activity against influenza A viruses[J].J Gen Virol,2012,93(Pt 5):980-986.
[10] LAKADAMYALI M,RUST M J,ZHUANG X.Endocytosis of influenza viruses[J].Microbes Infect,2004,6(10):929-936.
[11] HARRISON S C.Viral membrane fusion[J].Nat Struct Mol Biol,2008,15(7):690-698.
[12] YU K L,TORRI A F,LUO G,et al.Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine[J].Bioorg Med Chem Lett,2002,12(23):3379-3382.
[13] ZHU L,LI Y,LI S,et al.Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin[J].PLoS One,2011,6(12):e29120.
[14] THROSBY M,VAN DEN BRINK E,JONGENEELEN M,et al.Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells[J].PLoS One,2008,3(12):e3942.
[15] DREYFUS C,LAURSEN N S,KWAKS T,et al.Highly conserved protective epitopes on influenza B viruses[J].Science,2012,337(6100):1343-1348.
[16] MATROSOVICH M N,MATROSOVICH T Y,GRAY T,et al.Human and avian influenza viruses target different cell types in cultures of human airway epithelium[J].Proc Natl Acad Sci USA,2004,101(13):4620-4624.
[17] RUSSELL R J,HAIRE L F,STEVENS D J,et al.The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design[J].Nature,2006,443(7107):45-49.
[18] GUBAREVA L V,KAISER L,HAYDEN F G.Influenza virus neuraminidase inhibitors[J].Lancet,2000,355(9206):827-835.
[19] VON ITZSTEIN M,WU W Y,KOK G B,et al.Rational design of potent sialidase-based inhibitors of influenza virus replication[J].Nature,1993,363(6428):418-423.
[20] TSANG K W,ENG P,LIAM C K,et al.H5N1 influenza pandemic:contingency plans[J].Lancet,2005,366(9485):533-534.
[21] DAVIES B E.Pharmacokinetics of oseltamivir:an oral antiviral for the treatment and prophylaxis of influenza in diverse populations[J].J Antimicrob Chemother,2010,65 (Suppl 2):ii5-ii10.
[22] KOHNO S,KIDA H,MIZUGUCHI M,et al.Intravenous peramivir for treatment of influenza A and B virus infection in high-risk patients[J].Antimicrob Agents Chemother,2011,55(6):2803-2812.
[23] KOYAMA K,TAKAHASHI M,OITATE M,et al.CS-8958,a prodrug of the novel neuraminidase inhibitor R-125489,demonstrates a favorable long-retention profile in the mouse respiratory tract[J].Antimicrob Agents Chemother,2009,53(11):4845-4851.
[24] SAMSON M,PIZZORNO A,ABED Y,et al.Influenza virus resistance to neuraminidase inhibitors[J].Antiviral Res,2013,98(2):174-185.
[25] FENG E,YE D,LI J,et al.Recent advances in neuraminidase inhibitor development as anti-influenza drugs[J].Chem Med Chem,2012,7(9):1527-1536.
[26] WEIGHT A K,HALDAR J,ALVAREZ DE CIENFUEGOS L,et al.Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza A virus[J].J Pharm Sci,2011,100(3):831-835.
[27] PINTO L H,LAMB R A.The M2 proton channels of influenza A and B viruses[J].J Biol Chem,2006,281(14):8997-9000.
[28] ITO T,GORMAN O T,KAWAOKA Y,et al.Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins[J].J Virol,1991,65(10):5491-5498.
[29] WANG C,TAKEUCHI K,PINTO L H,et al.Ion channel activity of influenza A virus M2 protein:characterization of the amantadine block[J].J Virol,1993,67(9):5585-5594.
[30] MOSS R B,DAVEY R T,STEIGBIGEL R T,et al.Targeting pandemic influenza:a primer on influenza antivirals and drug resistance[J].J Antimicrob Chemother,2010,65(6):1086-1093.
[31] WANG J,WU Y,MA C,et al.Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus[J].Proc Natl Acad Sci USA,2013,110(4):1315-1320.
[32] WANG J,MA C,FIORIN G,et al.Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2[J].J Am Chem Soc,2011,133(32):12834-12841.
[33] BALANNIK V,WANG J,OHIGASHI Y,et al.Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus[J].Biochemistry,2009,48(50):11872-11882.
[34] WEI G,MENG W,GUO H,et al.Potent neutralization of influenza A virus by a single-domain antibody blocking M2 ion channel protein[J].PLoS One,2011,6(12):e28309.
[35] YE Q,GUU T S,MATA D A,et al.Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein[J].Mbio,2012,4(1):e00467-00412.
[36] CHENAVAS S,ESTROZI L F,SLAMA-SCHWOK A,et al.Monomeric nucleoprotein of influenza A virus[J].PLoS Pathog,2013,9(3):e1003275.
[37] AMORIM M J,KAO R Y,DIGARD P.Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection[J].J Virol,2013,87(8):4694-4703.
[38] LEJAL N,TARUS B,BOUGUYON E,et al.Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus[J].Antimicrob Agents Chemother,2013,57(5):2231-2242.
[39] HAO L,SAKURAI A,WATANABE T,et al.Drosophila RNAi screen identifies host genes important for influenza virus replication[J].Nature,2008,454(7206):890-893.
[40] ZHIRNOV O P,MATROSOVICH T Y,MATROSOVICH M N,et al.Aprotinin,a protease inhibitor,suppresses proteolytic activation of pandemic H1N1v influenza virus[J].Antivir Chem Chemother,2011,21(4):169-174.
[41] MALAKHOV M P,ASCHENBRENNER L M,SMEE D F,et al.Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection[J].Antimicrob Agents Chemother,2006,50(4):1470-1479.
[42] MOSS R B,HANSEN C,SANDERS R L,et al.A phase II study of DAS181,a novel host directed antiviral for the treatment of influenza infection[J].J Infect Dis,2012,206(12):1844-1851.
[43] TAKEDA M,LESER G P,RUSSELL C J,et al.Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion[J].Proc Natl Acad Sci USA,2003,100(25):14610-14617.
[44] WANG X,HINSON E R,CRESSWELL P.The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts[J].Cell Host Microbe,2007,2(2):96-105.
[45] TAN K S,NG W C,SEET J E,et al.Investigating the efficacy of pamidronate,a chemical inhibitor of farnesyl pyrophosphate synthase,in the inhibition of influenza virus infection in vitro and in vivo[J].Mol Med Rep,2014,9(1):51-56.
[46] GARCIA-SASTRE A.Lessons from lipids in the fight against influenza[J].Cell,2013,154(1):22-23.
[47] TAM V C,QUEHENBERGER O,OSHANSKY C M,et al.Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation[J].Cell,2013,154(1):213-227.
[48] LEVY B D,KOHLI P,GOTLINGER K,et al.Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness[J].J Immunol,2007,178(1):496-502.
[49] SERHAN C N.Resolution phase of inflammation:novel endogenous anti-inflammatory and proresolving lipid mediators and pathways[J].Annu Rev Immunol,2007,25:101-137.
[50] MORITA M,KUBA K,ICHIKAWA A,et al.The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza[J].Cell,2013,153(1):112-125.
[51] MARJUKI H,ALAM M I,EHRHARDT C,et al.Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling[J].J Biol Chem,2006,281(24):16707-16715.
[52] HAASBACH E,HARTMAYER C,PLANZ O.Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro[J].Antiviral Res,2013,98(2):319-324.
[53] NENCIONI L,DE CHIARA G,SGARBANTI R,et al.Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus:impact on virally induced apoptosis and viral replication[J].J Biol Chem,2009,284(23):16004-16015.
[54] LOREGIAN A,PALU G.How academic labs can approach the drug discovery process as a way to synergize with big pharma[J].Trends Microbiol,2013,21(6):261-264.

更新日期/Last Update: 2017-11-05