[1]王昌权.早期康复训练对急性脑梗死患者运动功能及血清脑源性神经营养因子水平的影响[J].新乡医学院学报,2017,34(10):946-948.[doi:10.7683/xxyxyxb.2017.10.021]
　WANG Chang-quan.Effect of early rehabilitation training on motor function and the level of serum brain-derived neurotrophic factor in patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2017,34(10):946-948.[doi:10.7683/xxyxyxb.2017.10.021]
点击复制

早期康复训练对急性脑梗死患者运动功能及血清脑源性神经营养因子水平的影响
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年10
页码:
946-948
栏目:
临床研究
出版日期:
2017-10-05

文章信息/Info

Title:
Effect of early rehabilitation training on motor function and the level of serum brain-derived neurotrophic factor in patients with acute cerebral infarction
作者:
王昌权
（黄冈市中心医院神经内科，湖北　黄冈　438000）
Author(s):
WANG Chang-quan
（Department of Neurology，Huanggang Central Hospital，Huanggang 438000，Hubei Province，China）
关键词:
急性脑梗死; 康复训练; 脑源性神经营养因子; 运动功能
Keywords:
acute cerebral infarction; rehabilitation training; brain-derived neurotrophic factor; motor function
分类号:
R493R743.3
DOI:
10.7683/xxyxyxb.2017.10.021
文献标志码:
A
摘要:
目的　探讨早期康复训练对急性脑梗死（ACI）患者肢体运动功能及血清脑源性神经营养因子（BDNF）水平的影响。方法　选择2015年1月至2016年1月黄冈市中心医院收治的ACI患者90例，将患者分为观察组和对照组，每组45例。对照组患者仅给予常规药物治疗，观察组患者同时给予早期康复训练，分别于治疗前后采用酶联免疫吸附双抗体夹心法检测血清BDNF水平，采用美国国立卫生研究院卒中量表（NIHSS）评估患者神经功能缺损情况，采用Fugl-Meyer运动功能评分法（FMA）评估患者肢体运动功能，采用Barthel指数评分评定患者日常生活能力（ADL），对2组患者血清BDNF水平、NIHSS 评分、FMA评分及ADL评分进行比较。结果　观察组和对照组患者治疗有效率分别为86.67%（39/45）、66.67%（30/45），观察组患者治疗有效率显著高于对照组（χ2=8.332，P<0.05）。治疗前2组患者神经功能缺损NIHSS评分比较差异无统计学意义（P>0.05）;2组患者治疗后神经功能缺损NIHSS评分显著低于治疗前（P<0.05）;治疗后观察组患者神经功能缺损NIHSS评分显著低于对照组（P<0.05）。治疗前2组患者血清BDNF水平比较差异无统计学意义（t=1.030，P>0.05）;2组患者治疗后血清BDNF水平显著高于治疗前（P<0.05）;治疗后观察组患者血清BDNF水平显著高于对照组（P<0.05）。治疗前2组患者FMA评分、ADL评分比较差异均无统计学意义（P>0.05）;2组患者治疗后FMA评分、ADL评分显著高于治疗前（P<0.05）;治疗后观察组患者FMA评分、ADL评分显著高于对照组（P<0.05）。结论　早期康复训练可有效促进ACI患者血清BDNF表达，改善患者神经功能缺损、肢体运动功能及ADL，提高治疗效果。
Abstract:
Objective　To explore the effect of early rehabilitation training on motor function and the level of serum brain-derived neurotrophic factor（BDNF） in patients with acute cerebral infarction（ACI）.Methods　A total of 90 patients with ACI were selected in Huanggang Central Hospital from January 2015 to January 2016.The patients were divided into observation group and control group，45 cases in each group.The patients in the control group were treated with conventional medication，and the patients in the observation group were treated with early rehabilitation training on the basis of conventional medication.The level of serum BDNF was detected by enzyme-linked immunosorbent double antibody sandwich method，the neurologic impairment was assessed by the national institutes of health stroke scale （NIHSS），the limb motor function was assessed by Fugl-Meyer assessment（FMA） score，and the activity of daily living （ADL） was assessed by Barthel index score before and after treatment.The serum BDNF level，NIHSS score，FMA score and ADL score were compared between the two groups.Results　The effective rate of in the observation group and control group was 86.67%（39/45） and 66.67% （30/45） respectively，the effective rate in the treatment group was significantly higher than that in the control group （χ2=8.332，P<0.05）.There was no significant difference in NIHSS score between the two groups before treatment （P>0.05）.The NIHSS score of neurologic impairment after treatment was significantly lower than that before treatment in the two groups （P<0.05）.The NIHSS score of neurologic impairment in the observation group was significantly lower than that in the control group after treatment （P<0.05）.There was no significant difference in serum BDNF level between the two groups before treatment （t=1.030，P>0.05）.The serum BDNF level after treatment was significantly higher than that before treatment in the two groups （P<0.05）.The serum BDNF level in the observation group was significantly higher than that in the control group after treatment （P<0.05）.There was no significant difference in FMA score and ADL score between the two groups before treatment （P>0.05）.The FMA score and ADL score after treatment were significantly higher than those before treatment in the two groups （P<0.05）.The FMA score and ADL score in the observation group were significantly higher than those in the control group after treatment （P<0.05）.Conclusion　Early rehabilitation training can effectively promote the expression of serum BDNF，improve neurological impairment，limb motor function and ADL，and improve the therapeutic effect in patients with ACI.

参考文献/References:

［1］　王琪，魏俊，李小琴.尤瑞克林注射液治疗急性脑梗死的疗效及安全性［J］.新乡医学院学报，2016，33（11）：980-982.
［2］　栾松，黄晓勇，刘娟，等.早期物理疗法联合药物对急性脑梗死患者血清BDNF和神经功能的影响［J］.中国实用神经疾病杂志，2014，17（24）：59-60.
［3］　甄君，罗世坚，赖家盈，等.早期康复训练对急性脑梗死患者血清BDNF及S100B蛋白表达的影响［J］.中华物理医学与康复杂志，2012，34（6）：470-471.
［4］　杨红亚，王同聚，王婷，等.早期电针治疗联合康复训练对急性脑梗死运动功能及生存质量的影响［J］.光明中医，2012，27（7）：1382-1384.
［5］　郑筱萸.中药新药临床研究指导原则［M］.北京：中国医药科技出版社，2002：99.
［6］　黄勇，刘培.脑梗死与缺血半暗带研究进展［J］.现代医药卫生，2007，23（17）：2594-2595.
［7］　郑臻，屈艺，母得志.脑源性神经营养因子在孤独症谱系障碍发病机制中的作用［J］.中华实用儿科临床杂志，2016，31（24）：1912-1914.
［8］　刘妍，陈桂生，王凯斌，等.早期康复训练对急性脑梗死患者肢体功能恢复及血清NGF和NSE水平的影响［J］.实用临床医学，2014，15（4）：10-13.
［9］　崔惠玲，罗正娥，曾新香，等.早期康复训练对急性脑梗死患者肢体运动功能恢复的疗效观察［J］.医学理论与实践，2013，26（5）：645-646.
［10］　贾秀萍，王瑞香，黄定玉.早期康复训练配合心理干预对急性脑梗死患者运动功能恢复的影响［J］.中西医结合心脑血管病杂志，2010，8（7）：876-877.

相似文献/References:

[1]何茶叶,刘 平,焦新彩,等.灯盏花素治疗急性脑梗死30例疗效观察[J].新乡医学院学报,2001,18(06):425.
[2]高连英,罗开国.降纤酶治疗急性脑梗死50例[J].新乡医学院学报,2003,20(02):143.
[3]陈娟,姬明丽.急性脑梗死患者血糖水平与梗死范围及预后的关系 [J].新乡医学院学报,2006,23(03):000.
[4]张同喜,张改芹.银杏达莫注射液治疗急性脑梗死61 例临床观察[J].新乡医学院学报,2006,23(05):507.
[5]毛向莹.依达拉奉治疗急性脑梗死疗效观察[J].新乡医学院学报,2008,25(01):045.
[6]赵红领,杜秦川.早期进展性脑梗死患者血浆D-二聚体水平变化[J].新乡医学院学报,2010,27(03):278.
[7]韩晨鹏,韩庆伟,姚文杰,等.急性脑梗死患者血清白细胞介素-6 及白细胞介素-8 和肿瘤坏死因子-α水平变化及临床意义[J].新乡医学院学报,2012,29(08):621.
[8]李　慧.阿替普酶溶栓后联合丹参多酚酸治疗急性脑梗死的疗效及安全性[J].新乡医学院学报,2019,36(11):1048.[doi:10.7683/xxyxyxb.2019.11.010]
　LI Hui.Efficacy and safety of alteplase combined with danshen polyphenolic acid in treatment of patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2019,36(10):1048.[doi:10.7683/xxyxyxb.2019.11.010]
[9]魏　亮,张小峰,张军峰.阿替普酶治疗急性脑梗死疗效观察[J].新乡医学院学报,2019,36(6):533.[doi:10.7683/xxyxyxb.2019.06.008]
　WEI Liang,ZHANG Xiao-feng,ZHANG Jun-feng.Effect of alteplase on acute cerebral infarction[J].Journal of Xinxiang Medical University,2019,36(10):533.[doi:10.7683/xxyxyxb.2019.06.008]
[10]李春燕,韩听锋,岳　磊.巴曲酶对急性脑梗死患者神经功能及日常生活能力和血液流变学的影响[J].新乡医学院学报,2019,36(6):544.[doi:10.7683/xxyxyxb.2019.06.011]
　LI Chun-yan,HAN Ting-feng,YUE Lei.Effect of batroxobin on neurological function，ability of daily living and hemorheology in patients with acute cerebral infarction[J].Journal of Xinxiang Medical University,2019,36(10):544.[doi:10.7683/xxyxyxb.2019.06.011]

更新日期/Last Update: 2017-10-05